National Center for Natural Products Research,
School of Pharmacy,
Department of Pharmacology,
National Center for Natural Products Research, School of Pharmacy
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A physiochemical mechanism of hemozoin (beta-hematin) synthesis by malaria parasite.
Biochemical and biophysical research communications Jan, 2002 | Pubmed ID: 11779214
Peripheral blood leucocytes ornithine decarboxylase activity in chronic myeloid leukemia patients: prognostic and therapeutic implications.
Leukemia research Apr, 2002 | Pubmed ID: 11839377
Haem polymerase as a novel target of antimalarial action of cyproheptadine.
Biochemical pharmacology Nov, 2002 | Pubmed ID: 12392821
Synthesis and biological evaluation of new imidazo[1,2-a]pyridine derivatives designed as mefloquine analogues.
Farmaco (Società chimica italiana : 1989) Oct, 2002 | Pubmed ID: 12420878
A novel active DNA topoisomerase I in Leishmania donovani.
The Journal of biological chemistry Feb, 2003 | Pubmed ID: 12444094
Antimicrobial and antiparasitic (+)-trans-hexahydrodibenzopyrans and analogues from Machaerium multiflorum.
Journal of natural products Jun, 2003 | Pubmed ID: 12828466
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge.
Journal of natural products Jun, 2003 | Pubmed ID: 12828469
Flow cytometric analysis of aneuploidy and S-phase fraction in chronic myeloid leukemia patients: role in early detection of accelerated phase.
Leukemia research Oct, 2003 | Pubmed ID: 12860009
Antiparasitic alkaloids from Psychotria klugii.
Journal of natural products Jul, 2003 | Pubmed ID: 12880315
Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.
Journal of medicinal chemistry Sep, 2003 | Pubmed ID: 13678403
Molecular and functional characterization of adenylate kinase 2 gene from Leishmania donovani.
European journal of biochemistry / FEBS Nov, 2003 | Pubmed ID: 14622299
Spectrophotometric determination of de novo hemozoin/beta-hematin formation in an in vitro assay.
Analytical biochemistry Feb, 2004 | Pubmed ID: 14715288
Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors.
Antimicrobial agents and chemotherapy Apr, 2004 | Pubmed ID: 15047563
A new antimalarial quassinoid from Simaba orinocensis.
Journal of natural products May, 2004 | Pubmed ID: 15165136
Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents.
European journal of medicinal chemistry Jun, 2004 | Pubmed ID: 15183913
An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme.
European journal of biochemistry / FEBS Sep, 2004 | Pubmed ID: 15317584
Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases.
Journal of natural products Aug, 2004 | Pubmed ID: 15332848
Antimicrobial and antileishmanial activities of hypocrellins A and B.
Antimicrobial agents and chemotherapy Nov, 2004 | Pubmed ID: 15504880
Targeting the hemozoin synthesis pathway for new antimalarial drug discovery: technologies for in vitro beta-hematin formation assay.
Combinatorial chemistry & high throughput screening Feb, 2005 | Pubmed ID: 15720198
Bisnortriterpenes from Salacia madagascariensis.
Journal of natural products Feb, 2005 | Pubmed ID: 15730255
Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues.
Bioorganic & medicinal chemistry Jul, 2005 | Pubmed ID: 15878667
Polyamine transport in parasites: a potential target for new antiparasitic drug development.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Feb, 2005 | Pubmed ID: 15907761
Biomimetic synthesis, antimicrobial, antileishmanial and antimalarial activities of euglobals and their analogues.
Bioorganic & medicinal chemistry Mar, 2006 | Pubmed ID: 16274995
Aromatic constituents of Uvaria grandiflora.
Journal of natural products Apr, 2006 | Pubmed ID: 16643056
Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases.
Journal of natural products Jul, 2006 | Pubmed ID: 16872140
Anti-plasmodial and anti-leishmanial activity of conformationally restricted pentamidine congeners.
The Journal of pharmacy and pharmacology Aug, 2006 | Pubmed ID: 16872549
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.
Bioorganic & medicinal chemistry Jan, 2007 | Pubmed ID: 17070063
8-Aminoquinolines: future role as antiprotozoal drugs.
Current opinion in infectious diseases Dec, 2006 | Pubmed ID: 17075340
Synthesis, antimalarial, antileishmanial, antimicrobial, cytotoxicity, and methemoglobin (MetHB) formation activities of new 8-quinolinamines.
Bioorganic & medicinal chemistry Jan, 2007 | Pubmed ID: 17084633
A new library of C-16 modified artemisinin analogs and evaluation of their anti-parasitic activities.
Combinatorial chemistry & high throughput screening Dec, 2006 | Pubmed ID: 17168678
Synthesis of isoquinuclidine analogs of chloroquine: antimalarial and antileishmanial activity.
Bioorganic & medicinal chemistry Jun, 2007 | Pubmed ID: 17400457
Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors.
Journal of medicinal chemistry Aug, 2007 | Pubmed ID: 17636950
Antileishmanial, antiplasmodial and cytotoxic activities of 12,16-dideoxy aegyptinone B from Zhumeria majdae Rech.f. & Wendelbo.
Phytotherapy research : PTR Mar, 2008 | Pubmed ID: 17886231
S-Euglobals: biomimetic synthesis, antileishmanial, antimalarial, and antimicrobial activities.
Bioorganic & medicinal chemistry Feb, 2008 | Pubmed ID: 17976995
Growth, drug susceptibility, and gene expression profiling of Plasmodium falciparum cultured in medium supplemented with human serum or lipid-rich bovine serum albumin [corrected].
Journal of biomolecular screening Dec, 2007 | Pubmed ID: 18087074
Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy.
Bioorganic & medicinal chemistry May, 2008 | Pubmed ID: 18362073
Novel bisbenzimidazoles with antileishmanial effectiveness.
Bioorganic & medicinal chemistry letters Apr, 2008 | Pubmed ID: 18367395
Probing the structures of leishmanial farnesyl pyrophosphate synthases: homology modeling and docking studies.
Journal of chemical information and modeling May, 2008 | Pubmed ID: 18419114
Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target.
Infectious disorders drug targets Mar, 2008 | Pubmed ID: 18473904
Infectious disorders drug targets--an arsenal of knowledge on pathogen targets.
Infectious disorders drug targets Mar, 2008 | Pubmed ID: 18473906
Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides.
Bioorganic & medicinal chemistry Jul, 2008 | Pubmed ID: 18571927
Kinetic studies and bioactivity of potential manzamine prodrugs.
Journal of natural products Jul, 2008 | Pubmed ID: 18598080
Current antiparasitic drug targets and a paradigm shift in discovery of new antiparasitic drugs and vaccines.
Current drug targets Nov, 2008 | Pubmed ID: 18991603
Plasmodium falciparum serine/threonine phoshoprotein phosphatases (PPP): from housekeeper to the 'holy grail'.
Current drug targets Nov, 2008 | Pubmed ID: 18991611
Antiparasitic, nematicidal and antifouling constituents from Juniperus berries.
Phytotherapy research : PTR Dec, 2008 | Pubmed ID: 19067375
Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa.
Journal of natural products Jan, 2009 | Pubmed ID: 19105653
Synthesis and antimalarial activities of cyclen 4-aminoquinoline analogs.
Antimicrobial agents and chemotherapy Apr, 2009 | Pubmed ID: 19171802
Analysis of quaternary structure of a [LDH-like] malate dehydrogenase of Plasmodium falciparum with oligomeric mutants.
Molecular and cellular biochemistry May, 2009 | Pubmed ID: 19184366
Bioactive (+)-manzamine A and (+)-8-hydroxymanzamine A tertiary bases and salts from Acanthostrongylophora ingens and their preparations.
Natural product communications Feb, 2009 | Pubmed ID: 19370920
Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes.
Toxicology and applied pharmacology Nov, 2009 | Pubmed ID: 19616568
Antimicrobial, antiparasitic and cytotoxic spermine alkaloids from Albizia schimperiana.
Natural product communications Jun, 2009 | Pubmed ID: 19634324
Structure and function of Plasmodium falciparum malate dehydrogenase: role of critical amino acids in co-substrate binding pocket.
Biochimie Nov-Dec, 2009 | Pubmed ID: 19772885
Structure-activity relationship studies of manzamine A: amidation of positions 6 and 8 of the beta-carboline moiety.
Bioorganic & medicinal chemistry Nov, 2009 | Pubmed ID: 19833520
Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers.
Bioorganic & medicinal chemistry Dec, 2009 | Pubmed ID: 19879765
Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson's disease.
Journal of ethnopharmacology Feb, 2010 | Pubmed ID: 19879939
Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.
Bioorganic & medicinal chemistry Jan, 2010 | Pubmed ID: 19914074
Biologically active tetranorditerpenoids from the fungus Sclerotinia homoeocarpa causal agent of dollar spot in turfgrass.
Journal of natural products Dec, 2009 | Pubmed ID: 19928902
Cytochrome P450-dependent toxicity of dapsone in human erythrocytes.
Journal of applied toxicology : JAT Apr, 2010 | Pubmed ID: 19998329
Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections.
Journal of medicinal chemistry Jan, 2010 | Pubmed ID: 20017491
Composition, standardization and chemical profiling of Banisteriopsis caapi, a plant for the treatment of neurodegenerative disorders relevant to Parkinson's disease.
Journal of ethnopharmacology Apr, 2010 | Pubmed ID: 20219660
Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.
Journal of natural products Mar, 2010 | Pubmed ID: 20337497
A structure-activity relationship study of the antimalarial and antileishmanial activities of nonpeptide macrocyclic histone deacetylase inhibitors.
ChemMedChem Aug, 2010 | Pubmed ID: 20533500
Antimicrobial and antiparasitic abietane diterpenoids from the roots of Clerodendrum eriophyllum.
Natural product communications Jun, 2010 | Pubmed ID: 20614808
Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton.
Journal of medicinal chemistry Aug, 2010 | Pubmed ID: 20669972
The antiplasmodial activity of norcantharidin analogs.
Bioorganic & medicinal chemistry letters Nov, 2010 | Pubmed ID: 20888768
Analysis of primaquine and its metabolite carboxyprimaquine in biological samples: enantiomeric separation, method validation and quantification.
Biomedical chromatography : BMC Sep, 2011 | Pubmed ID: 21058417
Synthesis, antiprotozoal, antimicrobial, β-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis(8-aminoquinolines).
Bioorganic & medicinal chemistry Jan, 2011 | Pubmed ID: 21172735
Antiparasitic and antimicrobial indolizidines from the leaves of Prosopis glandulosa var. glandulosa.
Planta medica Sep, 2011 | Pubmed ID: 21384317
Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library.
Journal of chemical information and modeling Apr, 2011 | Pubmed ID: 21428453
An entry to curcuphenol/elvirol core structures via a retro-Aldol reaction.
Chemistry & biodiversity Jun, 2011 | Pubmed ID: 21674782
Antiparasitic and antimicrobial isoflavanquinones from Abrus schimperi.
Natural product communications Nov, 2011 | Pubmed ID: 22224279
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
Bioorganic & medicinal chemistry letters Feb, 2012 | Pubmed ID: 22248858
Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs.
Bioorganic & medicinal chemistry letters Feb, 2012 | Pubmed ID: 22264472
Understanding the mechanisms for metabolism-linked hemolytic toxicity of primaquine against glucose 6-phosphate dehydrogenase deficient human erythrocytes: evaluation of eryptotic pathway.
Toxicology Mar, 2012 | Pubmed ID: 22330256
Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: synthesis and evaluation of anti-infective, β-haematin inhibition and cytotoxic activities.
European journal of medicinal chemistry Jun, 2012 | Pubmed ID: 22483965
Antiprotozoal and antimicrobial compounds from the plant pathogen Septoria pistaciarum.
Journal of natural products May, 2012 | Pubmed ID: 22530813
Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal and anti-HIV activities.
Chemical biology & drug design Jun, 2012 | Pubmed ID: 22703590
Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B.
Bioorganic & medicinal chemistry letters Aug, 2012 | Pubmed ID: 22781190
Pentacyclic ingamine alkaloids, a new antiplasmodial pharmacophore from the marine sponge Petrosid Ng5 Sp5.
Planta medica Oct, 2012 | Pubmed ID: 22903383
Synthesis and Structure-Activity Relationships of Lansine Analogues as Antileishmanial Agents.
ChemMedChem Sep, 2012 | Pubmed ID: 22987791
Antimicrobial and antiprotozoal activities of secondary metabolites from the fungus Eurotium repens.
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents Oct, 2012 | Pubmed ID: 23024574
Antiparasitic and anticancer carvotacetone derivatives of Sphaeranthus bullatus.
Natural product communications Sep, 2012 | Pubmed ID: 23074885
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