Guy A. Rutter

Department of Metabolism, Cell Biology and Functional Genomics

Affiliated withCell Biology and Functional Genomics Université de Montréal Nanyang Technological University

Research Area

Biology

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2024

Other Publications

Article	Year
Cell biology. Pancreas micromanages autophagy. Science (New York, N.Y.)\| PubMed ID: 25700502	2015
LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia. Molecular metabolism\| PubMed ID: 25830091	2015
DICER Inactivation Identifies Pancreatic β-Cell "Disallowed" Genes Targeted by MicroRNAs. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 26038943	2015
Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects. The Journal of biological chemistry\| PubMed ID: 26139601	2015
eZinCh-2: A Versatile, Genetically Encoded FRET Sensor for Cytosolic and Intraorganelle Zn(2+) Imaging. ACS chemical biology\| PubMed ID: 26151333	2015
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells. The Journal of biological chemistry\| PubMed ID: 26152717	2015
The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion. The Journal of biological chemistry\| PubMed ID: 26178371	2015
The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia. Nature\| PubMed ID: 26258299	2015
Changes in microRNA expression during differentiation of embryonic and induced pluripotent stem cells to definitive endoderm. Gene expression patterns : GEP\| PubMed ID: 26277621	2015
Intracellular zinc in insulin secretion and action: a determinant of diabetes risk? The Proceedings of the Nutrition Society\| PubMed ID: 26365743	2016
Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells. Molecular metabolism\| PubMed ID: 26413468	2015
Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets. Diabetologia\| PubMed ID: 26474776	2016
Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 26584158	2016
Optical Control of Insulin Secretion Using an Incretin Switch. Angewandte Chemie (International ed. in English)\| PubMed ID: 26585495	2015
Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats. Pancreas\| PubMed ID: 26731187	2016
The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion. Cell calcium\| PubMed ID: 26769314	2016
Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores. Diabetes\| PubMed ID: 26822088	2016
Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion. Diabetes\| PubMed ID: 26861785	2016
Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression. The Biochemical journal\| PubMed ID: 26936970	2016
Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance. PloS one\| PubMed ID: 27010458	2016
Allosteric Optical Control of a Class B G-Protein-Coupled Receptor. Angewandte Chemie (International ed. in English)\| PubMed ID: 27059784	2016
Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell metabolism\| PubMed ID: 27133129	2016
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus. Antioxidants & redox signaling\| PubMed ID: 27225690	2017
Zinc and diabetes. Archives of biochemistry and biophysics\| PubMed ID: 27262257	2016
Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 27329800	2016
Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production. Diabetologia\| PubMed ID: 27338626	2016
Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia. Nutrition & metabolism\| PubMed ID: 27390586	2016
Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose. Cell metabolism\| PubMed ID: 27452146	2016
Photoswitchable diacylglycerols enable optical control of protein kinase C. Nature chemical biology\| PubMed ID: 27454932	2016
Modeling Type 2 Diabetes GWAS Candidate Gene Function in hESCs. Cell stem cell\| PubMed ID: 27588741	2016
Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes. The Journal of biological chemistry\| PubMed ID: 27875315	2016
Diabetes: Controlling the identity of the adult pancreatic β cell. Nature reviews. Endocrinology\| PubMed ID: 28106150	2017
MiRNAs in β-Cell Development, Identity, and Disease. Frontiers in genetics\| PubMed ID: 28123396	2016
Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. American journal of human genetics\| PubMed ID: 28132686	2017
GABA signaling: A route to new pancreatic β cells. Cell research\| PubMed ID: 28186081	2017
Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart. Diabetes\| PubMed ID: 28232492	2017
Remote control of glucose homeostasis in vivo using photopharmacology. Scientific reports\| PubMed ID: 28331198	2017
SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome. Brain : a journal of neurology\| PubMed ID: 28334855	2017
Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice. Diabetologia\| PubMed ID: 28343277	2017
The transcription factor is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca dynamics in adult mice. The Journal of biological chemistry\| PubMed ID: 28377501	2017
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion. Molecular metabolism\| PubMed ID: 28377873	2017
Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene. Frontiers in genetics\| PubMed ID: 28443133	2017
Local and regional control of calcium dynamics in the pancreatic islet. Diabetes, obesity & metabolism\| PubMed ID: 28466490	2017
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Diabetologia\| PubMed ID: 29185012	2018
Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion. Diabetes\| PubMed ID: 29203512	2018
MiR-184 expression is regulated by AMPK in pancreatic islets. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 29269398	2018
A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells. Diabetes\| PubMed ID: 29284659	2018
Zn-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes. Mitochondrion\| PubMed ID: 29307859	2019
Control of insulin secretion by GLP-1. Peptides\| PubMed ID: 29412835	2018
Manipulation and Measurement of AMPK Activity in Pancreatic Islets. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29480490	2018
Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca Mobilization From Acidic Stores in Pancreatic α-Cells. Diabetes\| PubMed ID: 29563152	2018
Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. eLife\| PubMed ID: 29624168	2018
Targeting GLP-1 receptor trafficking to improve agonist efficacy. Nature communications\| PubMed ID: 29686402	2018
Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis. Diabetes, obesity & metabolism\| PubMed ID: 29748994	2018
Neuronatin regulates pancreatic β cell insulin content and secretion. The Journal of clinical investigation\| PubMed ID: 29864031	2018
Transcription factor-7-like 2 () gene acts downstream of the / kinase to control mTOR signaling, β cell growth, and insulin secretion. The Journal of biological chemistry\| PubMed ID: 29967064	2018
The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans. Diabetes, obesity & metabolism\| PubMed ID: 29974637	2018
Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity. Scientific reports\| PubMed ID: 30006590	2018
Mice harboring the human R138X loss-of-function mutation have increased insulin secretory capacity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30038024	2018
Chronic d-serine supplementation impairs insulin secretion. Molecular metabolism\| PubMed ID: 30093356	2018
The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis. Current diabetes reports\| PubMed ID: 30251179	2018
The α-cell in diabetes mellitus. Nature reviews. Endocrinology\| PubMed ID: 30310153	2018
An essential role for the Zn transporter ZIP7 in B cell development. Nature immunology\| PubMed ID: 30718914	2019
mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes. The Journal of clinical investigation\| PubMed ID: 31265435	2019
Metabolic and Functional Heterogeneity in Pancreatic β Cells. Journal of molecular biology\| PubMed ID: 31419404	2020
Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells. PLoS biology\| PubMed ID: 31430273	2019
Effects on pancreatic Beta and other Islet cells of the glucose-dependent insulinotropic polypeptide. Peptides\| PubMed ID: 31751656	2020
Dietary substitution of SFA with MUFA within high-fat diets attenuates hyperinsulinaemia and pancreatic islet dysfunction. The British journal of nutrition\| PubMed ID: 32122411	2020
Glucocorticoid Metabolism in Obesity and Following Weight Loss. Frontiers in endocrinology\| PubMed ID: 32153504	2020
Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 32207493	2020
Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release. JCI insight\| PubMed ID: 32229720	2020
Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists. Molecular metabolism\| PubMed ID: 32278079	2020
The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists. ACS pharmacology & translational science\| PubMed ID: 32296773	2020
The pore-forming subunit MCU of the mitochondrial Ca uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice. Diabetologia\| PubMed ID: 32350566	2020
The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Molecular metabolism\| PubMed ID: 32416313	2020
Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide. British journal of pharmacology\| PubMed ID: 32436216	2020
Age matters: Grading granule secretion in beta cells. The Journal of biological chemistry\| PubMed ID: 32620690	2020
Pancreatic islet secretion: gabbling via GABA. Nature metabolism\| PubMed ID: 32694865	2019
The roles of cytosolic and intramitochondrial Ca and the mitochondrial Ca-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation. The Journal of biological chemistry\| PubMed ID: 32709760	2020
A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice. EBioMedicine\| PubMed ID: 32739864	2020
Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation. Communications biology\| PubMed ID: 32859966	2020
Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity. Diabetologia\| PubMed ID: 32894309	2020
Control by Ca of mitochondrial structure and function in pancreatic β-cells. Cell calcium\| PubMed ID: 32961506	2020
Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice. Diabetologia\| PubMed ID: 33068125	2021
Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity. Diabetes\| PubMed ID: 33087457	2021
Covid-19 and Diabetes: A Complex Bidirectional Relationship. Frontiers in endocrinology\| PubMed ID: 33133024	2020
Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research. Frontiers in endocrinology\| PubMed ID: 33162936	2020
Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells. International journal of molecular sciences\| PubMed ID: 33182425	2020
Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes. Cell reports\| PubMed ID: 33264613	2020
Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors. The Journal of biological chemistry\| PubMed ID: 33268378	2021
Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis. Diabetologia\| PubMed ID: 33492421	2021
Importance of Both Imprinted Genes and Functional Heterogeneity in Pancreatic Beta Cells: Is There a Link? International journal of molecular sciences\| PubMed ID: 33498234	2021
PDX1 MAFA β-cells contribute to islet function and insulin release. Nature communications\| PubMed ID: 33514698	2021
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion. Cell reports\| PubMed ID: 33535042	2021
Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function. Frontiers in endocrinology\| PubMed ID: 33628198	2020
Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing. Frontiers in endocrinology\| PubMed ID: 33763030	2021
The Ca -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6. FEBS letters\| PubMed ID: 33960419	2021
Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes. Molecular metabolism\| PubMed ID: 33989778	2021
Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study. Diabetologia\| PubMed ID: 34110439	2021
Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1. Biochemical pharmacology\| PubMed ID: 34129856	2021
Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis. Science translational medicine\| PubMed ID: 34193609	2021
Author Correction: PDX1 MAFA β-cells contribute to islet function and insulin release. Nature communications\| PubMed ID: 34285239	2021
Mechanisms of Weight Loss After Obesity Surgery. Endocrine reviews\| PubMed ID: 34363458	2022
Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study. Diabetes\| PubMed ID: 34376475	2021
Intravital imaging of islet Ca dynamics reveals enhanced β cell connectivity after bariatric surgery in mice. Nature communications\| PubMed ID: 34453049	2021
Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice. The Journal of clinical investigation\| PubMed ID: 34491913	2021
Author Correction: Intravital imaging of islet Ca dynamics reveals enhanced β cell connectivity after bariatric surgery in mice. Nature communications\| PubMed ID: 34545099	2021
Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death. The Journal of endocrinology\| PubMed ID: 35017316	2022
Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35254894	2022
Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase. Diabetologia\| PubMed ID: 35294578	2022
Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency. Molecular metabolism\| PubMed ID: 35398277	2022
Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion. Diabetes\| PubMed ID: 35472764	2022
Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function. Diabetes\| PubMed ID: 35476777	2022
Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney. Diabetes\| PubMed ID: 35594379	2022
DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism. Developmental cell\| PubMed ID: 35597240	2022
In vivo and in vitro characterization of GL0034, a novel long-acting glucagon-like peptide-1 receptor agonist. Diabetes, obesity & metabolism\| PubMed ID: 35676825	2022
Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse. Cells\| PubMed ID: 35681432	2022
Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways. iScience\| PubMed ID: 36134336	2022
Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice. Frontiers in endocrinology\| PubMed ID: 36246869	2022
New-onset type 1 diabetes and severe acute respiratory syndrome coronavirus 2 infection. Immunology and cell biology\| PubMed ID: 36529987	2023
A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing. Journal of the Endocrine Society\| PubMed ID: 36694809	2023
Molecular phenotyping of single pancreatic islet leader beta cells by "Flash-Seq". Life sciences\| PubMed ID: 36706832	2023
Impact of COVID-19 during pregnancy on placental pathology, maternal and neonatal outcome - A cross-sectional study on anemic term pregnant women from a tertiary care hospital in southern In... Frontiers in endocrinology\| PubMed ID: 37025411	2023
Control of human pancreatic beta cell kinome by glucagon-like peptide-1 receptor biased agonism. Diabetes, obesity & metabolism\| PubMed ID: 37039251	2023
Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice. Science advances\| PubMed ID: 37134170	2023
Identification of biomarkers for glycaemic deterioration in type 2 diabetes. Nature communications\| PubMed ID: 37137910	2023
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing. The Biochemical journal\| PubMed ID: 37284792	2023
Impact of an loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice. Frontiers in endocrinology\| PubMed ID: 37396167	2023
Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell. Diabetologia\| PubMed ID: 37488322	2023
Multiple genetic variants at the locus affect local super-enhancer activity and influence pancreatic β-cell survival and function. bioRxiv : the preprint server for biology\| PubMed ID: 37502937	2023
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy. EMBO molecular medicine\| PubMed ID: 37933577	2023
Proinflammatory Cytokines, but not Glucolipotoxicity, Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells. bioRxiv : the preprint server for biology\| PubMed ID: 38187722	2023