Guy A. Rutter

Cell biology. Pancreas micromanages autophagy.

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia.

DICER Inactivation Identifies Pancreatic β-Cell "Disallowed" Genes Targeted by MicroRNAs.

Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.

eZinCh-2: A Versatile, Genetically Encoded FRET Sensor for Cytosolic and Intraorganelle Zn(2+) Imaging.

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.

The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia.

Changes in microRNA expression during differentiation of embryonic and induced pluripotent stem cells to definitive endoderm.

Intracellular zinc in insulin secretion and action: a determinant of diabetes risk?

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells.

Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets.

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.

Optical Control of Insulin Secretion Using an Incretin Switch.

Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats.

The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.

Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.

Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

Allosteric Optical Control of a Class B G-Protein-Coupled Receptor.

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.

Zinc and diabetes.

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production.

Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia.

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.

Photoswitchable diacylglycerols enable optical control of protein kinase C.

Modeling Type 2 Diabetes GWAS Candidate Gene Function in hESCs.

Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes.

Diabetes: Controlling the identity of the adult pancreatic β cell.

MiRNAs in β-Cell Development, Identity, and Disease.

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.

GABA signaling: A route to new pancreatic β cells.

Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart.

Remote control of glucose homeostasis in vivo using photopharmacology.

SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome.

Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice.

The transcription factor is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca dynamics in adult mice.

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.

Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene.

Local and regional control of calcium dynamics in the pancreatic islet.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion.

MiR-184 expression is regulated by AMPK in pancreatic islets.

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.

Zn-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes.

Control of insulin secretion by GLP-1.

Manipulation and Measurement of AMPK Activity in Pancreatic Islets.

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca Mobilization From Acidic Stores in Pancreatic α-Cells.

Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish.

Targeting GLP-1 receptor trafficking to improve agonist efficacy.

Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis.

Neuronatin regulates pancreatic β cell insulin content and secretion.

Transcription factor-7-like 2 () gene acts downstream of the / kinase to control mTOR signaling, β cell growth, and insulin secretion.

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.

Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity.

Mice harboring the human R138X loss-of-function mutation have increased insulin secretory capacity.

Chronic d-serine supplementation impairs insulin secretion.

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis.

The α-cell in diabetes mellitus.

An essential role for the Zn transporter ZIP7 in B cell development.

mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes.

Metabolic and Functional Heterogeneity in Pancreatic β Cells.

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.

Effects on pancreatic Beta and other Islet cells of the glucose-dependent insulinotropic polypeptide.

Dietary substitution of SFA with MUFA within high-fat diets attenuates hyperinsulinaemia and pancreatic islet dysfunction.

Glucocorticoid Metabolism in Obesity and Following Weight Loss.

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.

Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release.

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists.

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists.

The pore-forming subunit MCU of the mitochondrial Ca uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.

Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide.

Age matters: Grading granule secretion in beta cells.

Pancreatic islet secretion: gabbling via GABA.

The roles of cytosolic and intramitochondrial Ca and the mitochondrial Ca-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation.

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.

Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation.

Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity.

Control by Ca of mitochondrial structure and function in pancreatic β-cells.

Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice.

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity.

Covid-19 and Diabetes: A Complex Bidirectional Relationship.

Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research.

Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells.

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors.

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.

Importance of Both Imprinted Genes and Functional Heterogeneity in Pancreatic Beta Cells: Is There a Link?

PDX1 MAFA β-cells contribute to islet function and insulin release.

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion.

Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function.

Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing.

The Ca -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6.

Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes.

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study.

Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1.

Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis.

Author Correction: PDX1 MAFA β-cells contribute to islet function and insulin release.

Mechanisms of Weight Loss After Obesity Surgery.

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study.

Intravital imaging of islet Ca dynamics reveals enhanced β cell connectivity after bariatric surgery in mice.

Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice.

Author Correction: Intravital imaging of islet Ca dynamics reveals enhanced β cell connectivity after bariatric surgery in mice.

Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death.

Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.

Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase.

Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency.

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion.

Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function.

Vertical Sleeve Gastrectomy Lowers SGLT2/Slc5a2 Expression in the Mouse Kidney.

DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism.

In vivo and in vitro characterization of GL0034, a novel long-acting glucagon-like peptide-1 receptor agonist.

Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse.

Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways.

Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice.

New-onset type 1 diabetes and severe acute respiratory syndrome coronavirus 2 infection.

A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing.

Molecular phenotyping of single pancreatic islet leader beta cells by "Flash-Seq".

Impact of COVID-19 during pregnancy on placental pathology, maternal and neonatal outcome - A cross-sectional study on anemic term pregnant women from a tertiary care hospital in southern India.

Control of human pancreatic beta cell kinome by glucagon-like peptide-1 receptor biased agonism.

Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice.

Identification of biomarkers for glycaemic deterioration in type 2 diabetes.

Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing.

Impact of an loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice.

Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell.

Multiple genetic variants at the locus affect local super-enhancer activity and influence pancreatic β-cell survival and function.

Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy.

Proinflammatory Cytokines, but not Glucolipotoxicity, Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells.