Alex Vitkin

Department of Medical Biophysics, University of Toronto

Affiliated withUniversity of Toronto Princess Margaret Cancer Centre

Research Area

Cancer Research

Biography

Alex Vitkin has not added Biography.
If you are Alex Vitkin and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
Models and measurements of light intensity changes during laser interstitial thermal therapy: implications for optical monitoring of the coagulation boundary location. Physics in medicine and biology\| PubMed ID: 12630747	2003
Radiance-based monitoring of the extent of tissue coagulation during laser interstitial thermal therapy. Optics letters\| PubMed ID: 15143640	2004
Micromachined array tip for multifocus fiber-based optical coherence tomography. Optics letters\| PubMed ID: 15352360	2004
Development of a laser photothermoacoustic frequency-swept system for subsurface imaging: theory and experiment. The Journal of the Acoustical Society of America\| PubMed ID: 15658704	2004
Suitability of radiochromic medium for real-time optical measurements of ionizing radiation dose. Medical physics\| PubMed ID: 15895598	2005
Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience. Gastrointestinal endoscopy\| PubMed ID: 15933695	2005
Optical and acoustic properties at 1064 nm of polyvinyl chloride-plastisol for use as a tissue phantom in biomedical optoacoustics. Physics in medicine and biology\| PubMed ID: 16177502	2005
Characterization and real-time optical measurements of the ionizing radiation dose response for a new radiochromic medium. Medical physics\| PubMed ID: 16193781	2005
Laser photothermoacoustic heterodyned lock-in depth profilometry in turbid tissue phantoms. Physical review. E, Statistical, nonlinear, and soft matter physics\| PubMed ID: 16383646	2005
Information content of point radiance measurements in turbid media: implications for interstitial optical property quantification. Applied optics\| PubMed ID: 16579581	2006
Feasibility of interstitial Doppler optical coherence tomography for in vivo detection of microvascular changes during photodynamic therapy. Lasers in surgery and medicine\| PubMed ID: 16927368	2006
Angular measurements of light scattered by turbid chiral media using linear Stokes polarimeter. Journal of biomedical optics\| PubMed ID: 16965133	2006
Ex vivo imaging of chronic total occlusions using forward-looking optical coherence tomography. Lasers in surgery and medicine\| PubMed ID: 17096416	2007
Perturbative diffusion theory formalism for interpreting temporal light intensity changes during laser interstitial thermal therapy. Physics in medicine and biology\| PubMed ID: 17327655	2007
Energy dependence (75 kVp to 18 MV) of radiochromic films assessed using a real-time optical dosimeter. Medical physics\| PubMed ID: 17388161	2007
Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions. Journal of biomedical optics\| PubMed ID: 17614730	2007
Doppler optical coherence tomography monitoring of microvascular tissue response during photodynamic therapy in an animal model of Barrett's esophagus. Gastrointestinal endoscopy\| PubMed ID: 17643708	2007
Intra-irradiation changes in the signal of polymer-based dosimeter (GAFCHROMIC EBT) due to dose rate variations. Physics in medicine and biology\| PubMed ID: 17975282	2007
Determination of the optical properties of turbid media using relative interstitial radiance measurements: Monte Carlo study, experimental validation, and sensitivity analysis. Journal of biomedical optics\| PubMed ID: 18163843	2007
Electrostatic forward-viewing scanning probe for Doppler optical coherence tomography using a dissipative polymer catheter. Optics letters\| PubMed ID: 18382508	2008
Speckle variance detection of microvasculature using swept-source optical coherence tomography. Optics letters\| PubMed ID: 18594688	2008
High power wavelength linearly swept mode locked fiber laser for OCT imaging. Optics express\| PubMed ID: 18773019	2008
Temperature and hydration effects on absorbance spectra and radiation sensitivity of a radiochromic medium. Medical physics\| PubMed ID: 18975701	2008
Interstitial Doppler optical coherence tomography as a local tumor necrosis predictor in photodynamic therapy of prostatic carcinoma: an in vivo study. Cancer research\| PubMed ID: 19047181	2008
High-power wavelength-swept laser in Littman telescope-less polygon filter and dual-amplifier configuration for multichannel optical coherence tomography. Optics letters\| PubMed ID: 19756114	2009
Oxygen-independent degradation of HIF-alpha via bioengineered VHL tumour suppressor complex. EMBO molecular medicine\| PubMed ID: 20049704	2009
Depolarization of light in turbid media: a scattering event resolved Monte Carlo study. Applied optics\| PubMed ID: 20062501	2010
In vivo endoscopic multi-beam optical coherence tomography. Physics in medicine and biology\| PubMed ID: 20071753	2010
Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration. Journal of biomedical optics\| PubMed ID: 20210429	2010
Optimized speckle variance OCT imaging of microvasculature. Optics letters\| PubMed ID: 20410985	2010
Polarimetry-based method to extract geometry-independent metrics of tissue anisotropy. Optics letters\| PubMed ID: 20680061	2010
Two-photon microscopy of healthy, infarcted and stem-cell treated regenerating heart. Journal of biophotonics\| PubMed ID: 20827682	2011
Elastin overexpression by cell-based gene therapy preserves matrix and prevents cardiac dilation. Journal of cellular and molecular medicine\| PubMed ID: 22435995	2012
Quantitative correlation between light depolarization and transport albedo of various porcine tissues. Journal of biomedical optics\| PubMed ID: 22559678	2012
Quantifying tissue microvasculature with speckle variance optical coherence tomography. Optics letters\| PubMed ID: 22859125	2012
Optical assessment of tissue anisotropy in ex vivo distended rat bladders. Journal of biomedical optics\| PubMed ID: 23224197	2012
Detecting axial heterogeneity of birefringence in layered turbid media using polarized light imaging. Biomedical optics express\| PubMed ID: 23243575	2012
A spinal cord window chamber model for in vivo longitudinal multimodal optical and acoustic imaging in a murine model. PloS one\| PubMed ID: 23516432	2013
Texture analysis of optical coherence tomography speckle for characterizing biological tissues in vivo. Optics letters\| PubMed ID: 23595458	2013
Optical coherence tomography platform for microvascular imaging and quantification: initial experience in late oral radiation toxicity patients. Journal of biomedical optics\| PubMed ID: 23843086	2013
Assessment of local structural disorders of the bladder wall in partial bladder outlet obstruction using polarized light imaging. Biomedical optics express\| PubMed ID: 24575354	2014
Tissue multifractality and Born approximation in analysis of light scattering: a novel approach for precancers detection. Scientific reports\| PubMed ID: 25139583	2014
Dynamic light scattering arising from flowing Brownian particles: analytical model in optical coherence tomography conditions. Journal of biomedical optics\| PubMed ID: 25517256	2014
Polarized light imaging in biomedicine: emerging Mueller matrix methodologies for bulk tissue assessment. Journal of biomedical optics\| PubMed ID: 25793658	2015
Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography. Biomedical optics express\| PubMed ID: 25909028	2015
Talin Is Required Continuously for Cardiomyocyte Remodeling during Heart Growth in Drosophila. PloS one\| PubMed ID: 26110760	2015
Polarimetric assessment of healthy and radiofrequency ablated porcine myocardial tissue. Journal of biophotonics\| PubMed ID: 26394151	2016
Multi-modal optical imaging characterization of atherosclerotic plaques. Journal of biophotonics\| PubMed ID: 26604168	2016
Dynamic light scattering by flowing Brownian particles measured with optical coherence tomography: impact of the optical system. Journal of biomedical optics\| PubMed ID: 26803671	2016
Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking. Journal of biophotonics\| PubMed ID: 27159850	2016
Optical clearing of melanoma in vivo: characterization by diffuse reflectance spectroscopy and optical coherence tomography. Journal of biomedical optics\| PubMed ID: 27300502	2016
Analysis of scattering statistics and governing distribution functions in optical coherence tomography. Biomedical optics express\| PubMed ID: 27446689	2016
Special Issue: Selected papers from the Topical Problems of Biophotonics conference. Journal of biophotonics\| PubMed ID: 27480644	2016
Microvascular contrast enhancement in optical coherence tomography using microbubbles. Journal of biomedical optics\| PubMed ID: 27533242	2016
Rapid Detection of Necrosis in Breast Cancer with Desorption Electrospray Ionization Mass Spectrometry. Scientific reports\| PubMed ID: 27734938	2016
Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography. Journal of biomedical optics\| PubMed ID: 27824215	2016
Optimized Mass Spectrometry Analysis Workflow with Polarimetric Guidance for ex vivo and in situ Sampling of Biological Tissues. Scientific reports\| PubMed ID: 28352074	2017
Polarization image segmentation of radiofrequency ablated porcine myocardial tissue. PloS one\| PubMed ID: 28380013	2017
Optical coherence elastography for strain dynamics measurements in laser correction of cornea shape. Journal of biophotonics\| PubMed ID: 28493426	2017
K-distribution three-dimensional mapping of biological tissues in optical coherence tomography. Journal of biophotonics\| PubMed ID: 28700119	2018
Statistical properties of dynamic speckles from flowing Brownian scatterers in the vicinity of the image plane in optical coherence tomography. Biomedical optics express\| PubMed ID: 28736652	2017
Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography. Journal of biophotonics\| PubMed ID: 28853237	2018
Accurate viscosity measurements of flowing aqueous glucose solutions with suspended scatterers using a dynamic light scattering approach with optical coherence tomography. Journal of biomedical optics\| PubMed ID: 28861954	2017
Flexible polarimetric probe for 3 × 3 Mueller matrix measurements of biological tissue. Scientific reports\| PubMed ID: 28931853	2017
Preclinical longitudinal imaging of tumor microvascular radiobiological response with functional optical coherence tomography. Scientific reports\| PubMed ID: 29311686	2018
Optical coherence tomography-based angiography device with real-time angiography B-scans visualization and hand-held probe for everyday clinical use. Journal of biophotonics\| PubMed ID: 29737042	2018
Monte Carlo simulation of polarization-sensitive second-harmonic generation and propagation in biological tissue. Journal of biophotonics\| PubMed ID: 29971932	2018
Wide-field tissue polarimetry allows efficient localized mass spectrometry imaging of biological tissues. Chemical science\| PubMed ID: 30155015	2016
Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography. Journal of biomedical optics\| PubMed ID: 30315644	2018
Novel methodology to image stromal tissue and assess its morphological features with polarized light: towards a tumour microenvironment prognostic signature. Biomedical optics express\| PubMed ID: 31452988	2019
Analysis of low-scattering regions in optical coherence tomography: applications to neurography and lymphangiography. Biomedical optics express\| PubMed ID: 31453005	2019
Photon mayhem: new directions in diagnostic and therapeutic photomedicine. Biomedical engineering letters\| PubMed ID: 31456888	2019
A multiscale Mueller polarimetry module for a stereo zoom microscope. Biomedical engineering letters\| PubMed ID: 31456893	2019
Impact of velocity gradient in Poiseuille flow on the statistics of coherent radiation scattered by flowing Brownian particles in optical coherence tomography. Journal of biomedical optics\| PubMed ID: 31562708	2019
Correction to: A multiscale Mueller polarimetry module for a stereo zoom microscope. Biomedical engineering letters\| PubMed ID: 32175138	2020
Novel quantitative signature of tumor stromal architecture: polarized light imaging differentiates between myxoid and sclerotic human breast cancer stroma. Biomedical optics express\| PubMed ID: 32637252	2020
Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models. Cancers\| PubMed ID: 32708501	2020
Peri-tumoural stroma collagen organization of invasive ductal carcinoma assessed by polarized light microscopy differs between OncotypeDX risk group. Journal of biophotonics\| PubMed ID: 32710711	2020
Non-invasive voiding assessment in conscious mice. Bladder (San Francisco, Calif.)\| PubMed ID: 32775475	2018
Volumetric tumor delineation and assessment of its early response to radiotherapy with optical coherence tomography. Biomedical optics express\| PubMed ID: 34123510	2021
Low-coherence photonic method of electrochemical processes monitoring. Scientific reports\| PubMed ID: 34131215	2021
Toward a quantitative method for estimating tumour-stroma ratio in breast cancer using polarized light microscopy. Biomedical optics express\| PubMed ID: 34221657	2021
Diattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by Mueller matrix polarimetry. Scientific reports\| PubMed ID: 34625628	2021
Discriminating turbid media by scatterer size and scattering coefficient using backscattered linearly and circularly polarized light. Biomedical optics express\| PubMed ID: 34858683	2021
Bridging the macro to micro resolution gap with angiographic optical coherence tomography and dynamic contrast enhanced MRI. Scientific reports\| PubMed ID: 35210476	2022
Longitudinal in-vivo quantification of tumour microvascular heterogeneity by optical coherence angiography in pre-clinical radiation therapy. Scientific reports\| PubMed ID: 35414078	2022
Polarimetric biomarkers of peri-tumoral stroma can correlate with 5-year survival in patients with left-sided colorectal cancer. Scientific reports\| PubMed ID: 35879367	2022
Binary dose level classification of tumour microvascular response to radiotherapy using artificial intelligence analysis of optical coherence tomography images. Scientific reports\| PubMed ID: 35978040	2022
Detection and differentiation of semi-transparent materials simulating biological structures using optical coherence tomography: a phantom study. Journal of biomedical optics\| PubMed ID: 36221173	2022
Spatial helicity response metric to quantify particle size and turbidity of heterogeneous media through circular polarization imaging. Scientific reports\| PubMed ID: 36755076	2023
Advances in laser speckle imaging: From qualitative to quantitative hemodynamic assessment. Journal of biophotonics\| PubMed ID: 37545037	2024
Mueller matrix polarization parameters correlate with local recurrence in patients with stage III colorectal cancer. Scientific reports\| PubMed ID: 37591987	2023
Spatial analysis of polarimetric images to enhance near-surface sampling sensitivity: feasibility in demineralized teeth and other tissue-like media. Journal of biomedical optics\| PubMed ID: 37692083	2023
Protein classification by autofluorescence spectral shape analysis using machine learning. Talanta\| PubMed ID: 37714041	2024
Machine learning based local recurrence prediction in colorectal cancer using polarized light imaging. Journal of biomedical optics\| PubMed ID: 38077502	2024