Alex Vitkin

Department of Medical Biophysics, University of Toronto

Affiliated withUniversity of Toronto Princess Margaret Cancer Centre

Research Area

Cancer Research

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2024

Other Publications

Article	Year
Models and measurements of light intensity changes during laser interstitial thermal therapy: implications for optical monitoring of the coagulation boundary location. Physics in medicine and biology\| PubMed ID: 12630747	2003
Radiance-based monitoring of the extent of tissue coagulation during laser interstitial thermal therapy. Optics letters\| PubMed ID: 15143640	2004
Micromachined array tip for multifocus fiber-based optical coherence tomography. Optics letters\| PubMed ID: 15352360	2004
Development of a laser photothermoacoustic frequency-swept system for subsurface imaging: theory and experiment. The Journal of the Acoustical Society of America\| PubMed ID: 15658704	2004
Suitability of radiochromic medium for real-time optical measurements of ionizing radiation dose. Medical physics\| PubMed ID: 15895598	2005
Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience. Gastrointestinal endoscopy\| PubMed ID: 15933695	2005
Optical and acoustic properties at 1064 nm of polyvinyl chloride-plastisol for use as a tissue phantom in biomedical optoacoustics. Physics in medicine and biology\| PubMed ID: 16177502	2005
Characterization and real-time optical measurements of the ionizing radiation dose response for a new radiochromic medium. Medical physics\| PubMed ID: 16193781	2005
Laser photothermoacoustic heterodyned lock-in depth profilometry in turbid tissue phantoms. Physical review. E, Statistical, nonlinear, and soft matter physics\| PubMed ID: 16383646	2005
Information content of point radiance measurements in turbid media: implications for interstitial optical property quantification. Applied optics\| PubMed ID: 16579581	2006
Feasibility of interstitial Doppler optical coherence tomography for in vivo detection of microvascular changes during photodynamic therapy. Lasers in surgery and medicine\| PubMed ID: 16927368	2006
Angular measurements of light scattered by turbid chiral media using linear Stokes polarimeter. Journal of biomedical optics\| PubMed ID: 16965133	2006
Ex vivo imaging of chronic total occlusions using forward-looking optical coherence tomography. Lasers in surgery and medicine\| PubMed ID: 17096416	2007
Perturbative diffusion theory formalism for interpreting temporal light intensity changes during laser interstitial thermal therapy. Physics in medicine and biology\| PubMed ID: 17327655	2007
Energy dependence (75 kVp to 18 MV) of radiochromic films assessed using a real-time optical dosimeter. Medical physics\| PubMed ID: 17388161	2007
Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions. Journal of biomedical optics\| PubMed ID: 17614730	2007
Doppler optical coherence tomography monitoring of microvascular tissue response during photodynamic therapy in an animal model of Barrett's esophagus. Gastrointestinal endoscopy\| PubMed ID: 17643708	2007
Intra-irradiation changes in the signal of polymer-based dosimeter (GAFCHROMIC EBT) due to dose rate variations. Physics in medicine and biology\| PubMed ID: 17975282	2007
Determination of the optical properties of turbid media using relative interstitial radiance measurements: Monte Carlo study, experimental validation, and sensitivity analysis. Journal of biomedical optics\| PubMed ID: 18163843	2007
Electrostatic forward-viewing scanning probe for Doppler optical coherence tomography using a dissipative polymer catheter. Optics letters\| PubMed ID: 18382508	2008
Speckle variance detection of microvasculature using swept-source optical coherence tomography. Optics letters\| PubMed ID: 18594688	2008
High power wavelength linearly swept mode locked fiber laser for OCT imaging. Optics express\| PubMed ID: 18773019	2008
Temperature and hydration effects on absorbance spectra and radiation sensitivity of a radiochromic medium. Medical physics\| PubMed ID: 18975701	2008
Interstitial Doppler optical coherence tomography as a local tumor necrosis predictor in photodynamic therapy of prostatic carcinoma: an in vivo study. Cancer research\| PubMed ID: 19047181	2008
High-power wavelength-swept laser in Littman telescope-less polygon filter and dual-amplifier configuration for multichannel optical coherence tomography. Optics letters\| PubMed ID: 19756114	2009
Oxygen-independent degradation of HIF-alpha via bioengineered VHL tumour suppressor complex. EMBO molecular medicine\| PubMed ID: 20049704	2009
Depolarization of light in turbid media: a scattering event resolved Monte Carlo study. Applied optics\| PubMed ID: 20062501	2010
In vivo endoscopic multi-beam optical coherence tomography. Physics in medicine and biology\| PubMed ID: 20071753	2010
Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration. Journal of biomedical optics\| PubMed ID: 20210429	2010
Optimized speckle variance OCT imaging of microvasculature. Optics letters\| PubMed ID: 20410985	2010
Polarimetry-based method to extract geometry-independent metrics of tissue anisotropy. Optics letters\| PubMed ID: 20680061	2010
Two-photon microscopy of healthy, infarcted and stem-cell treated regenerating heart. Journal of biophotonics\| PubMed ID: 20827682	2011
Elastin overexpression by cell-based gene therapy preserves matrix and prevents cardiac dilation. Journal of cellular and molecular medicine\| PubMed ID: 22435995	2012
Quantitative correlation between light depolarization and transport albedo of various porcine tissues. Journal of biomedical optics\| PubMed ID: 22559678	2012
Quantifying tissue microvasculature with speckle variance optical coherence tomography. Optics letters\| PubMed ID: 22859125	2012
Optical assessment of tissue anisotropy in ex vivo distended rat bladders. Journal of biomedical optics\| PubMed ID: 23224197	2012
Detecting axial heterogeneity of birefringence in layered turbid media using polarized light imaging. Biomedical optics express\| PubMed ID: 23243575	2012
A spinal cord window chamber model for in vivo longitudinal multimodal optical and acoustic imaging in a murine model. PloS one\| PubMed ID: 23516432	2013
Texture analysis of optical coherence tomography speckle for characterizing biological tissues in vivo. Optics letters\| PubMed ID: 23595458	2013
Optical coherence tomography platform for microvascular imaging and quantification: initial experience in late oral radiation toxicity patients. Journal of biomedical optics\| PubMed ID: 23843086	2013
Assessment of local structural disorders of the bladder wall in partial bladder outlet obstruction using polarized light imaging. Biomedical optics express\| PubMed ID: 24575354	2014
Tissue multifractality and Born approximation in analysis of light scattering: a novel approach for precancers detection. Scientific reports\| PubMed ID: 25139583	2014
Dynamic light scattering arising from flowing Brownian particles: analytical model in optical coherence tomography conditions. Journal of biomedical optics\| PubMed ID: 25517256	2014
Polarized light imaging in biomedicine: emerging Mueller matrix methodologies for bulk tissue assessment. Journal of biomedical optics\| PubMed ID: 25793658	2015
Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography. Biomedical optics express\| PubMed ID: 25909028	2015
Talin Is Required Continuously for Cardiomyocyte Remodeling during Heart Growth in Drosophila. PloS one\| PubMed ID: 26110760	2015
Polarimetric assessment of healthy and radiofrequency ablated porcine myocardial tissue. Journal of biophotonics\| PubMed ID: 26394151	2016
Multi-modal optical imaging characterization of atherosclerotic plaques. Journal of biophotonics\| PubMed ID: 26604168	2016
Dynamic light scattering by flowing Brownian particles measured with optical coherence tomography: impact of the optical system. Journal of biomedical optics\| PubMed ID: 26803671	2016
Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking. Journal of biophotonics\| PubMed ID: 27159850	2016
Optical clearing of melanoma in vivo: characterization by diffuse reflectance spectroscopy and optical coherence tomography. Journal of biomedical optics\| PubMed ID: 27300502	2016
Analysis of scattering statistics and governing distribution functions in optical coherence tomography. Biomedical optics express\| PubMed ID: 27446689	2016
Special Issue: Selected papers from the Topical Problems of Biophotonics conference. Journal of biophotonics\| PubMed ID: 27480644	2016
Microvascular contrast enhancement in optical coherence tomography using microbubbles. Journal of biomedical optics\| PubMed ID: 27533242	2016
Rapid Detection of Necrosis in Breast Cancer with Desorption Electrospray Ionization Mass Spectrometry. Scientific reports\| PubMed ID: 27734938	2016
Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography. Journal of biomedical optics\| PubMed ID: 27824215	2016
Optimized Mass Spectrometry Analysis Workflow with Polarimetric Guidance for ex vivo and in situ Sampling of Biological Tissues. Scientific reports\| PubMed ID: 28352074	2017
Polarization image segmentation of radiofrequency ablated porcine myocardial tissue. PloS one\| PubMed ID: 28380013	2017
Optical coherence elastography for strain dynamics measurements in laser correction of cornea shape. Journal of biophotonics\| PubMed ID: 28493426	2017
K-distribution three-dimensional mapping of biological tissues in optical coherence tomography. Journal of biophotonics\| PubMed ID: 28700119	2018
Statistical properties of dynamic speckles from flowing Brownian scatterers in the vicinity of the image plane in optical coherence tomography. Biomedical optics express\| PubMed ID: 28736652	2017
Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography. Journal of biophotonics\| PubMed ID: 28853237	2018
Accurate viscosity measurements of flowing aqueous glucose solutions with suspended scatterers using a dynamic light scattering approach with optical coherence tomography. Journal of biomedical optics\| PubMed ID: 28861954	2017
Flexible polarimetric probe for 3 × 3 Mueller matrix measurements of biological tissue. Scientific reports\| PubMed ID: 28931853	2017
Preclinical longitudinal imaging of tumor microvascular radiobiological response with functional optical coherence tomography. Scientific reports\| PubMed ID: 29311686	2018
Optical coherence tomography-based angiography device with real-time angiography B-scans visualization and hand-held probe for everyday clinical use. Journal of biophotonics\| PubMed ID: 29737042	2018
Monte Carlo simulation of polarization-sensitive second-harmonic generation and propagation in biological tissue. Journal of biophotonics\| PubMed ID: 29971932	2018
Wide-field tissue polarimetry allows efficient localized mass spectrometry imaging of biological tissues. Chemical science\| PubMed ID: 30155015	2016
Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography. Journal of biomedical optics\| PubMed ID: 30315644	2018
Novel methodology to image stromal tissue and assess its morphological features with polarized light: towards a tumour microenvironment prognostic signature. Biomedical optics express\| PubMed ID: 31452988	2019
Analysis of low-scattering regions in optical coherence tomography: applications to neurography and lymphangiography. Biomedical optics express\| PubMed ID: 31453005	2019
Photon mayhem: new directions in diagnostic and therapeutic photomedicine. Biomedical engineering letters\| PubMed ID: 31456888	2019
A multiscale Mueller polarimetry module for a stereo zoom microscope. Biomedical engineering letters\| PubMed ID: 31456893	2019
Impact of velocity gradient in Poiseuille flow on the statistics of coherent radiation scattered by flowing Brownian particles in optical coherence tomography. Journal of biomedical optics\| PubMed ID: 31562708	2019
Correction to: A multiscale Mueller polarimetry module for a stereo zoom microscope. Biomedical engineering letters\| PubMed ID: 32175138	2020
Novel quantitative signature of tumor stromal architecture: polarized light imaging differentiates between myxoid and sclerotic human breast cancer stroma. Biomedical optics express\| PubMed ID: 32637252	2020
Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models. Cancers\| PubMed ID: 32708501	2020
Peri-tumoural stroma collagen organization of invasive ductal carcinoma assessed by polarized light microscopy differs between OncotypeDX risk group. Journal of biophotonics\| PubMed ID: 32710711	2020
Non-invasive voiding assessment in conscious mice. Bladder (San Francisco, Calif.)\| PubMed ID: 32775475	2018
Volumetric tumor delineation and assessment of its early response to radiotherapy with optical coherence tomography. Biomedical optics express\| PubMed ID: 34123510	2021
Low-coherence photonic method of electrochemical processes monitoring. Scientific reports\| PubMed ID: 34131215	2021
Toward a quantitative method for estimating tumour-stroma ratio in breast cancer using polarized light microscopy. Biomedical optics express\| PubMed ID: 34221657	2021
Diattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by Mueller matrix polarimetry. Scientific reports\| PubMed ID: 34625628	2021
Discriminating turbid media by scatterer size and scattering coefficient using backscattered linearly and circularly polarized light. Biomedical optics express\| PubMed ID: 34858683	2021
Bridging the macro to micro resolution gap with angiographic optical coherence tomography and dynamic contrast enhanced MRI. Scientific reports\| PubMed ID: 35210476	2022
Longitudinal in-vivo quantification of tumour microvascular heterogeneity by optical coherence angiography in pre-clinical radiation therapy. Scientific reports\| PubMed ID: 35414078	2022
Polarimetric biomarkers of peri-tumoral stroma can correlate with 5-year survival in patients with left-sided colorectal cancer. Scientific reports\| PubMed ID: 35879367	2022
Binary dose level classification of tumour microvascular response to radiotherapy using artificial intelligence analysis of optical coherence tomography images. Scientific reports\| PubMed ID: 35978040	2022
Detection and differentiation of semi-transparent materials simulating biological structures using optical coherence tomography: a phantom study. Journal of biomedical optics\| PubMed ID: 36221173	2022
Spatial helicity response metric to quantify particle size and turbidity of heterogeneous media through circular polarization imaging. Scientific reports\| PubMed ID: 36755076	2023
Advances in laser speckle imaging: From qualitative to quantitative hemodynamic assessment. Journal of biophotonics\| PubMed ID: 37545037	2024
Mueller matrix polarization parameters correlate with local recurrence in patients with stage III colorectal cancer. Scientific reports\| PubMed ID: 37591987	2023
Spatial analysis of polarimetric images to enhance near-surface sampling sensitivity: feasibility in demineralized teeth and other tissue-like media. Journal of biomedical optics\| PubMed ID: 37692083	2023
Protein classification by autofluorescence spectral shape analysis using machine learning. Talanta\| PubMed ID: 37714041	2024
Machine learning based local recurrence prediction in colorectal cancer using polarized light imaging. Journal of biomedical optics\| PubMed ID: 38077502	2024