Department of Medicine,
Division of Endocrinology,
Department of Medicine, Division of Endocrinology
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HIV protease inhibitors acutely impair glucose-stimulated insulin release.
Diabetes Jul, 2003 | Pubmed ID: 12829635
Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels.
American journal of physiology. Heart and circulatory physiology Apr, 2004 | Pubmed ID: 14656703
Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets.
Diabetes Dec, 2004 | Pubmed ID: 15561916
Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels.
Diabetes Dec, 2004 | Pubmed ID: 15561946
Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal K(ATP).
Journal of molecular and cellular cardiology Oct, 2005 | Pubmed ID: 16099470
ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy.
Diabetes Sep, 2005 | Pubmed ID: 16123353
ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes.
Diabetes Oct, 2005 | Pubmed ID: 16186394
Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent islets.
The Journal of biological chemistry Feb, 2006 | Pubmed ID: 16344552
Critical role of gap junction coupled KATP channel activity for regulated insulin secretion.
PLoS biology Feb, 2006 | Pubmed ID: 16402858
Hyperinsulinism in mice with heterozygous loss of K(ATP) channels.
Diabetologia Oct, 2006 | Pubmed ID: 16924481
Expression of ATP-insensitive KATP channels in pancreatic beta-cells underlies a spectrum of diabetic phenotypes.
Diabetes Nov, 2006 | Pubmed ID: 17065331
Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells.
PLoS medicine Oct, 2008 | Pubmed ID: 18959471
Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy.
Circulation research Jan, 2009 | Pubmed ID: 19023131
Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus.
Cell metabolism Feb, 2009 | Pubmed ID: 19187772
K(ATP) channelopathies in the pancreas.
Pflugers Archiv : European journal of physiology Jul, 2010 | Pubmed ID: 19921246
Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in mice.
Cell metabolism Dec, 2009 | Pubmed ID: 19945402
HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels.
Journal of molecular and cellular cardiology Mar, 2011 | Pubmed ID: 21185839
Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes.
Diabetes Oct, 2011 | Pubmed ID: 21813803
Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.
Journal of the American Heart Association Aug, 2013 | Pubmed ID: 23974906
Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy.
Cell metabolism May, 2014 | Pubmed ID: 24746806
Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion.
Cell reports Jun, 2014 | Pubmed ID: 24910426
Remission of severe neonatal diabetes with very early sulfonylurea treatment.
Diabetes care Mar, 2015 | Pubmed ID: 25715421
Pancreatic β-cell identity in diabetes.
Diabetes, obesity & metabolism Sep, 2016 | Pubmed ID: 27615139
An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion.
Molecular metabolism Aug, 2016 | Pubmed ID: 27656398
Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.
The Journal of clinical investigation Dec, 2016 | Pubmed ID: 27820699
Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the KATP channel.
The Journal of general physiology Jan, 2017 | Pubmed ID: 27956473
Should I Stay or Should I Go: A Clash of α-Cell Identity.
Cell metabolism Mar, 2017 | Pubmed ID: 28273469
Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway.
Autophagy , 2017 | Pubmed ID: 28853981
High-fat-diet-induced remission of diabetes in a subset of K -GOF insulin-secretory-deficient mice.
Diabetes, obesity & metabolism Nov, 2018 | Pubmed ID: 29896801
Cardiovascular consequences of KATP overactivity in Cantu syndrome.
JCI insight 08, 2018 | Pubmed ID: 30089727
In vivo monitoring of intracellular Ca dynamics in the pancreatic β-cells of zebrafish embryos.
Islets , 2018 | Pubmed ID: 30521410
The role of membrane excitability in pancreatic β-cell glucotoxicity.
Scientific reports May, 2019 | Pubmed ID: 31061431
ABCC9-related Intellectual disability Myopathy Syndrome is a K channelopathy with loss-of-function mutations in ABCC9.
Nature communications Oct, 2019 | Pubmed ID: 31575858
Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity.
The Journal of clinical investigation Mar, 2020 | Pubmed ID: 31821173
Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry.
American journal of medical genetics. Part C, Seminars in medical genetics Dec, 2019 | Pubmed ID: 31828977
Kir6.1-dependent K channels in lymphatic smooth muscle and vessel dysfunction in mice with Kir6.1 gain-of-function.
The Journal of physiology May, 2020 | Pubmed ID: 32372450
Alterations in pancreatic islet cell function in response to small bowel resection.
American journal of physiology. Gastrointestinal and liver physiology Jul, 2020 | Pubmed ID: 32463335
The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome.
Function (Oxford, England) , 2020 | Pubmed ID: 32865539
Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome.
JCI insight Nov, 2020 | Pubmed ID: 33170808
Preferential Gq signaling in diabetes: an electrical switch in incretin action and in diabetes progression?
The Journal of clinical investigation Dec, 2020 | Pubmed ID: 33196460
Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice.
JCI insight 03, 2021 | Pubmed ID: 33529173
Gain-of-Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Jul, 2021 | Pubmed ID: 33831261
Cognitive deficits and impaired hippocampal long-term potentiation in K-induced DEND syndrome.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2021 | Pubmed ID: 34732576
ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?
Diabetes Mar, 2022 | Pubmed ID: 35196393
Genetic Reduction of Glucose Metabolism Preserves Functional β-Cell Mass in KATP-Induced Neonatal Diabetes.
Diabetes Jun, 2022 | Pubmed ID: 35294000
A Unique High-Output Cardiac Hypertrophy Phenotype Arising From Low Systemic Vascular Resistance in Cantu Syndrome.
Journal of the American Heart Association Dec, 2022 | Pubmed ID: 36515236
Glucokinase Inhibition: A Novel Treatment for Diabetes?
Diabetes Feb, 2023 | Pubmed ID: 36669001
KATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer's disease-related pathology.
JCI insight May, 2023 | Pubmed ID: 37129980
Intermittent fasting protects β-cell identity and function in a type-2 diabetes model.
Metabolism: clinical and experimental Apr, 2024 | Pubmed ID: 38307325
Sophia H. Roberts1,2,
Louai Alrata1,2,
Dahlia Abdulsattar1,2,
Karan Joseph1,2,
Wahid Abu-Amer1,2,
Mohamed Zaghloul1,2,
Batool Arif1,2,
Tarek Alhamad3,
Maria S. Remedi4,
Yiing Lin5,
Mohamed A. Zayed1,2,6,7
1Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine,
2CardioVascular Research Innovation in Surgery and Engineering Center, Washington University School of Medicine,
3Department of Medicine, Division of Nephrology, Washington University School of Medicine,
4Department of Medicine, Division of Endocrinology, Washington University School of Medicine,
5Department of Surgery, Section of Transplant Surgery, Washington University School of Medicine,
6Division of Molecular Cell Biology, Washington University School of Medicine,
7Department of Biomedical Engineering, Washington University McKelvey School of Engineering
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