Laboratory of Experimental Intensive Care and Anesthesiology
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Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients.
Frontiers in physiology , 2018 | Pubmed ID: 30519189
Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts.
Cardiovascular research Aug, 2019 | Pubmed ID: 30649212
Helium-Induced Changes in Circulating Caveolin in Mice Suggest a Novel Mechanism of Cardiac Protection.
International journal of molecular sciences May, 2019 | Pubmed ID: 31146391
Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2019 | Pubmed ID: 31724838
Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation.
Vox sanguinis Jul, 2020 | Pubmed ID: 32166810
Novel Anti-inflammatory Effects of Canagliflozin Involving Hexokinase II in Lipopolysaccharide-Stimulated Human Coronary Artery Endothelial Cells.
Cardiovascular drugs and therapy Dec, 2021 | Pubmed ID: 33048256
NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart.
Frontiers in immunology , 2020 | Pubmed ID: 33362773
The Redox Modulating Sonlicromanol Active Metabolite KH176m and the Antioxidant MPG Protect Against Short-Duration Cardiac Ischemia-Reperfusion Injury.
Cardiovascular drugs and therapy Aug, 2021 | Pubmed ID: 33914182
Effects of Hyperglycemia and Diabetes Mellitus on Coagulation and Hemostasis.
Journal of clinical medicine May, 2021 | Pubmed ID: 34072487
Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species.
International journal of molecular sciences Jun, 2021 | Pubmed ID: 34205045
Empagliflozin reduces oxidative stress through inhibition of the novel inflammation/NHE/[Na]/ROS-pathway in human endothelial cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Feb, 2022 | Pubmed ID: 34896968
Direct cardiac effects of SGLT2 inhibitors.
Cardiovascular diabetology Mar, 2022 | Pubmed ID: 35303888
Investigating Peripheral Regional Anesthesia Using Induced Pluripotent Stem Cell Technology: Exploring Novel Terrain.
Anesthesia and analgesia Sep, 2022 | Pubmed ID: 35977370
Use of a human induced pluripotent stem cell-derived dorsal root ganglion neurone model to study analgesics in vitro: proof of principle using lidocaine.
British journal of anaesthesia Dec, 2022 | Pubmed ID: 36244818
Canagliflozin inhibits inflammasome activation in diabetic endothelial cells - Revealing a novel calcium-dependent anti-inflammatory effect of canagliflozin on human diabetic endothelial cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Mar, 2023 | Pubmed ID: 36623448
Sodium Glucose Cotransporter-2 Inhibitor Empagliflozin Reduces Infarct Size Independently of Sodium Glucose Cotransporter-2.
Circulation Jan, 2023 | Pubmed ID: 36649392
Early hyperbaric oxygen therapy is associated with favorable outcome in patients with iatrogenic cerebral arterial gas embolism: systematic review and individual patient data meta-analysis of observational studies.
Critical care (London, England) Jul, 2023 | Pubmed ID: 37434172
The effects of resuscitation with different plasma products on endothelial permeability and organ injury in a rat pneumosepsis model.
Intensive care medicine experimental Sep, 2023 | Pubmed ID: 37728777
The Effects of Heparan Sulfate Infusion on Endothelial and Organ Injury in a Rat Pneumosepsis Model.
Journal of clinical medicine Oct, 2023 | Pubmed ID: 37892576
Computer tomography perfusion patterns in iatrogenic cerebral arterial gas embolism: A retrospective cohort study.
European journal of radiology Nov, 2023 | Pubmed ID: 38043382
Empagliflozin prevents oxidative stress in human coronary artery endothelial cells via the NHE/PKC/NOX axis.
Redox biology Feb, 2024 | Pubmed ID: 38061206
Chemotherapy-induced peripheral neuropathy models constructed from human induced pluripotent stem cells and directly converted cells: a systematic review.
Pain Sep, 2024 | Pubmed ID: 38381959
Re: Cerebral arterial air emboli on immediate post-endovascular treatment CT are associated with poor short- and long-term clinical outcomes in acute ischaemic stroke patients.
Journal of neuroradiology = Journal de neuroradiologie May, 2024 | Pubmed ID: 38382803
Empagliflozin mitigates cardiac hypertrophy through cardiac RSK/NHE-1 inhibition.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie May, 2024 | Pubmed ID: 38522235
Ketonaemia during cardiopulmonary bypass surgery: a prospective observational study.
British journal of anaesthesia Sep, 2024 | Pubmed ID: 38918169
Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2.
Basic research in cardiology Oct, 2024 | Pubmed ID: 39046464
Raoul A. Fakkert1,2,3,
Nina C. Weber3,
Benedikt Preckel1,3,
Robert A. van Hulst1,2,
Inge A. Mulder*,4,5,6,
Robert P. Weenink*,1,2
1Department of Anesthesiology, Amsterdam UMC,
2Department of Hyperbaric Medicine, Amsterdam UMC,
3Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC,
4Biomedical Engineering and Physics, Amsterdam UMC,
5Microcirculation, Amsterdam Cardiovascular Sciences,
6Neurovascular Disorders, Amsterdam Neurosciences
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