Centre of Excellence for Alzheimer's Disease Research and Care,
School of Medical Sciences,
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical sciences
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Association between the presenilin-1 mutation Glu318Gly and complaints of memory impairment.
Neurobiology of aging Jan-Feb, 2002 | Pubmed ID: 11755019
Transition metal chelator therapy--a potential treatment for Alzheimer's disease?
Frontiers in bioscience : a journal and virtual library Apr, 2002 | Pubmed ID: 11897554
Intraneuronal advanced glycation endproducts in presenilin-1 Alzheimer's disease.
Neuroreport Apr, 2002 | Pubmed ID: 11973454
Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition.
Journal of neurochemistry May, 2002 | Pubmed ID: 12065653
Association of interleukin-1 polymorphisms with Alzheimer's disease in Australia.
Annals of neurology Jun, 2002 | Pubmed ID: 12112093
Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins.
Peptides Jul, 2002 | Pubmed ID: 12128091
Amyloid beta protein precursor metabolism as a modulator of islet beta-cell function.
Journal of Alzheimer's disease : JAD Aug, 2001 | Pubmed ID: 12214043
Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology.
Journal of neuroscience research Nov, 2002 | Pubmed ID: 12391612
Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription.
Journal of neurochemistry Mar, 2003 | Pubmed ID: 12614323
Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia.
Brain : a journal of neurology Apr, 2003 | Pubmed ID: 12615641
Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants.
Free radical biology & medicine Apr, 2003 | Pubmed ID: 12684092
Can testosterone replacement decrease the memory problem of old age?
Medical hypotheses Jun, 2003 | Pubmed ID: 12699720
XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms.
The Biochemical journal Aug, 2003 | Pubmed ID: 12780348
Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype.
Biological psychiatry Jul, 2003 | Pubmed ID: 12873803
Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease.
Neurobiology of aging Sep, 2003 | Pubmed ID: 12885573
Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia.
Biological psychiatry Sep, 2003 | Pubmed ID: 13129656
Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta.
Brain research. Brain research reviews Sep, 2003 | Pubmed ID: 14499458
Molecular and cellular basis for anti-amyloid therapy in Alzheimer disease.
Alzheimer disease and associated disorders Oct-Dec, 2003 | Pubmed ID: 14657791
Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression.
Journal of neurochemistry Feb, 2004 | Pubmed ID: 14720205
Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.
The Journal of biological chemistry May, 2004 | Pubmed ID: 14871891
One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men.
Psychoneuroendocrinology Sep, 2004 | Pubmed ID: 15219659
Effects of apolipoprotein E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes.
Journal of neuroscience research Aug, 2004 | Pubmed ID: 15264223
Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits.
Journal of neurochemistry Aug, 2004 | Pubmed ID: 15287908
The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?
Pharmacological research : the official journal of the Italian Pharmacological Society Oct, 2004 | Pubmed ID: 15304237
Frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies.
Journal of neurology Sep, 2004 | Pubmed ID: 15372253
Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells.
Alzheimer disease and associated disorders Oct-Dec, 2004 | Pubmed ID: 15592142
光纤衍射的头发可以提供在阿尔茨海默病筛查: 人类和动物模型研究。
Medical science monitor : international medical journal of experimental and clinical research Feb, 2005 | Pubmed ID: 15668631
Dementia and testosterone levels in men.
JAMA : the journal of the American Medical Association Feb, 2005 | Pubmed ID: 15687304
TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels.
Human mutation Jul, 2005 | Pubmed ID: 15895461
Common versus uncommon causes of dementia.
International psychogeriatrics / IPA , 2005 | Pubmed ID: 16240481
Plasma Abeta42 correlates positively with increased body fat in healthy individuals.
Journal of Alzheimer's disease : JAD Dec, 2005 | Pubmed ID: 16340084
Interaction between testosterone and apolipoprotein E epsilon4 status on cognition in healthy older men.
The Journal of clinical endocrinology and metabolism Mar, 2006 | Pubmed ID: 16368754
The role of gonadotropins in Alzheimer's disease: potential neurodegenerative mechanisms.
Endocrine Apr, 2006 | Pubmed ID: 16785601
Oxidative stress in a rat model of chronic gliosis.
Neurobiology of aging Jul, 2007 | Pubmed ID: 16797785
A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease.
Human molecular genetics Aug, 2006 | Pubmed ID: 16825285
The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid.
Neurochemical research Apr-May, 2007 | Pubmed ID: 16944319
Reproductive hormones modulate oxidative stress in Alzheimer's disease.
Antioxidants & redox signaling Nov-Dec, 2006 | Pubmed ID: 17034349
Mutations in progranulin explain atypical phenotypes with variants in MAPT.
Brain : a journal of neurology Nov, 2006 | Pubmed ID: 17071927
B-vitamins reduce plasma levels of beta amyloid.
Neurobiology of aging Feb, 2008 | Pubmed ID: 17113685
Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: a putative marker of an ongoing inflammatory process.
Experimental gerontology Apr, 2007 | Pubmed ID: 17140756
Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment.
Journal of Alzheimer's disease : JAD Dec, 2006 | Pubmed ID: 17183150
Androgens in the etiology of Alzheimer's disease in aging men and possible therapeutic interventions.
Journal of Alzheimer's disease : JAD Sep, 2007 | Pubmed ID: 17917157
Fluoro-2-deoxy-D-glucose (FDG)-PET in APOEepsilon4 carriers in the Australian population.
Journal of Alzheimer's disease : JAD Mar, 2008 | Pubmed ID: 18376055
Gonadotropins and cognition in older women.
Journal of Alzheimer's disease : JAD Apr, 2008 | Pubmed ID: 18430994
Infection and Alzheimer's disease: the APOE epsilon4 connection and lipid metabolism.
Journal of Alzheimer's disease : JAD May, 2008 | Pubmed ID: 18487850
Luteinizing hormone levels are positively correlated with plasma amyloid-beta protein levels in elderly men.
Journal of Alzheimer's disease : JAD Jun, 2008 | Pubmed ID: 18560131
Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease.
Journal of neuroinflammation , 2008 | Pubmed ID: 18715507
Distinct effects of testosterone on plasma and cerebrospinal fluid amyloid-beta levels.
Journal of Alzheimer's disease : JAD Sep, 2008 | Pubmed ID: 18780973
Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes.
Neurobiology of aging Sep, 2010 | Pubmed ID: 18950899
Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity.
International journal of clinical and experimental medicine , 2008 | Pubmed ID: 19079689
Association of cardiovascular factors and Alzheimer's disease plasma amyloid-beta protein in subjective memory complainers.
Journal of Alzheimer's disease : JAD , 2009 | Pubmed ID: 19363264
Androgens and Alzheimer's disease.
Current opinion in endocrinology, diabetes, and obesity Jun, 2009 | Pubmed ID: 19373081
Abeta aggregation and possible implications in Alzheimer's disease pathogenesis.
Journal of cellular and molecular medicine Mar, 2009 | Pubmed ID: 19374683
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease.
International psychogeriatrics / IPA Aug, 2009 | Pubmed ID: 19470201
The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eepsilon4 carriers and non-carriers.
Journal of Alzheimer's disease : JAD , 2009 | Pubmed ID: 19494432
Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals.
Journal of Alzheimer's disease : JAD , 2009 | Pubmed ID: 19494438
Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos.
Experimental cell research Oct, 2009 | Pubmed ID: 19563801
Complex splicing and neural expression of duplicated tau genes in zebrafish embryos.
Journal of Alzheimer's disease : JAD , 2009 | Pubmed ID: 19584432
Predicting memory decline as a risk factor for Alzheimer's disease in older post-menopausal women: quod erat demonstrandum?
International psychogeriatrics / IPA Mar, 2010 | Pubmed ID: 19814842
Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology.
Molecular neurodegeneration , 2009 | Pubmed ID: 19845940
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
The Journal of biological chemistry Dec, 2009 | Pubmed ID: 19864413
The structure and function of Alzheimer's gamma secretase enzyme complex.
Critical reviews in clinical laboratory sciences , 2009 | Pubmed ID: 19958215
Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease.
Journal of neurochemistry Dec, 2009 | Pubmed ID: 20050287
Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry.
Journal of Alzheimer's disease : JAD , 2010 | Pubmed ID: 20164599
Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease.
Molecular neurodegeneration , 2010 | Pubmed ID: 20205790
Relationship between atrophy and beta-amyloid deposition in Alzheimer disease.
Annals of neurology Mar, 2010 | Pubmed ID: 20373343
Plasma amyloid-beta as a biomarker in Alzheimer's disease: the AIBL study of aging.
Journal of Alzheimer's disease : JAD , 2010 | Pubmed ID: 20413897
Addressing population aging and Alzheimer's disease through the Australian imaging biomarkers and lifestyle study: collaboration with the Alzheimer's Disease Neuroimaging Initiative.
Alzheimer's & dementia : the journal of the Alzheimer's Association May, 2010 | Pubmed ID: 20451879
APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice.
Journal of Alzheimer's disease : JAD , 2010 | Pubmed ID: 20555142
Larger temporal volume in elderly with high versus low beta-amyloid deposition.
Brain : a journal of neurology Nov, 2010 | Pubmed ID: 20739349
Ocular biomarkers for early detection of Alzheimer's disease.
Journal of Alzheimer's disease : JAD , 2010 | Pubmed ID: 20847434
Zebrafish as a tool in Alzheimer's disease research.
Biochimica et biophysica acta Mar, 2011 | Pubmed ID: 20920580
Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers.
Neurobiology of aging Jun, 2012 | Pubmed ID: 20961668
Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease.
Brain : a journal of neurology Mar, 2011 | Pubmed ID: 21310725
Effects of anticholinergic drugs on cognitive function in older Australians: results from the AIBL study.
Dementia and geriatric cognitive disorders , 2011 | Pubmed ID: 21389718
A web-based normative data tool for assessing cognitive performance in healthy older Australians.
The Medical journal of Australia Feb, 2011 | Pubmed ID: 21401481
Advances in structural and molecular neuroimaging in Alzheimer's disease.
The Medical journal of Australia Feb, 2011 | Pubmed ID: 21401483
New lexicon and criteria for the diagnosis of Alzheimer's disease.
Lancet neurology Apr, 2011 | Pubmed ID: 21435594
Memory function in a mouse genetic model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD , 2011 | Pubmed ID: 21460433
Cognition and beta-amyloid in preclinical Alzheimer's disease: data from the AIBL study.
Neuropsychologia Jul, 2011 | Pubmed ID: 21529702
Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.
Annals of neurology Jun, 2011 | Pubmed ID: 21681798
The dynamics of CD147 in Alzheimer's disease development and pathology.
Journal of Alzheimer's disease : JAD , 2011 | Pubmed ID: 21694447
Predictors of rapid cognitive decline in Alzheimer's disease: results from the Australian imaging, biomarkers and lifestyle (AIBL) study of ageing.
International psychogeriatrics / IPA Feb, 2012 | Pubmed ID: 21749739
Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study.
Journal of Alzheimer's disease : JAD , 2011 | Pubmed ID: 21891867
Direct exposure of guinea pig CNS to human luteinizing hormone increases cerebrospinal fluid and cerebral beta amyloid levels.
Neuroendocrinology , 2011 | Pubmed ID: 21985789
Evaluation of color preference in zebrafish for learning and memory.
Journal of Alzheimer's disease : JAD , 2012 | Pubmed ID: 22008261
Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease.
Journal of neuroscience methods Mar, 2012 | Pubmed ID: 22226742
Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study.
Journal of clinical and experimental neuropsychology , 2012 | Pubmed ID: 22248010
Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice.
Endocrinology Jun, 2012 | Pubmed ID: 22514046
Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.
Molecular neurodegeneration , 2012 | Pubmed ID: 22534039
Robust homeostasis of Presenilin1 protein levels by transcript regulation.
Neuroscience letters Jun, 2012 | Pubmed ID: 22580062
Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study.
Brain : a journal of neurology Jul, 2012 | Pubmed ID: 22628162
Clinical and biomarker changes in dominantly inherited Alzheimer's disease.
The New England journal of medicine Aug, 2012 | Pubmed ID: 22784036
Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease.
Archives of neurology Jul, 2012 | Pubmed ID: 22801742
Latrepirdine (Dimebon™) Enhances Autophagy and Reduces Intracellular GFP-Aβ42 Levels in Yeast.
Journal of Alzheimer's disease : JAD Jan, 2012 | Pubmed ID: 22903131
Pharmacological effects of cannabinoids on the reference and working memory functions in mice.
Psychopharmacology Aug, 2012 | Pubmed ID: 22903389
Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-β
Journal of Alzheimer's disease : JAD Sep, 2012 | Pubmed ID: 23001710
Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial.
BMC psychiatry Oct, 2012 | Pubmed ID: 23050829
Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults.
Neurology Oct, 2012 | Pubmed ID: 23071163
Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network.
Clinical investigation Oct, 2012 | Pubmed ID: 23139856
Avdesh Avdesh*,1,2,
Mengqi Chen*,1,3,
Mathew T. Martin-Iverson1,2,4,
Alinda Mondal1,3,
Daniel Ong1,
Stephanie Rainey-Smith1,3,
Kevin Taddei1,3,
Michael Lardelli5,
David M. Groth6,
Giuseppe Verdile1,3,
Ralph N. Martins1,2,3,7
1Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical sciences, Edith Cowan University,
2Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, University of Western Australia,
3, McCusker Alzheimer's Research foundation,
4School of Medicine and Pharmacology, University of Western Australia ,
5Department of Molecular and Biomedical Sciences, University of Adelaide,
6School of Biomedical Sciences, Curtin University of Technology,
7School of Psychiatry and Clinical Neurosciences, University of Western Australia
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