Ralph N. Martins

Association between the presenilin-1 mutation Glu318Gly and complaints of memory impairment.

Transition metal chelator therapy--a potential treatment for Alzheimer's disease?

Intraneuronal advanced glycation endproducts in presenilin-1 Alzheimer's disease.

Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition.

Association of interleukin-1 polymorphisms with Alzheimer's disease in Australia.

Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins.

Amyloid beta protein precursor metabolism as a modulator of islet beta-cell function.

Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology.

Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription.

Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia.

Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants.

Can testosterone replacement decrease the memory problem of old age?

XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms.

Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype.

Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease.

Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia.

Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta.

Molecular and cellular basis for anti-amyloid therapy in Alzheimer disease.

Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression.

Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.

One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men.

Effects of apolipoprotein E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes.

Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits.

The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?

Frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies.

Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells.

光纤衍射的头发可以提供在阿尔茨海默病筛查： 人类和动物模型研究。

Dementia and testosterone levels in men.

TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels.

Common versus uncommon causes of dementia.

Plasma Abeta42 correlates positively with increased body fat in healthy individuals.

Interaction between testosterone and apolipoprotein E epsilon4 status on cognition in healthy older men.

The role of gonadotropins in Alzheimer's disease: potential neurodegenerative mechanisms.

Oxidative stress in a rat model of chronic gliosis.

A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease.

The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid.

Reproductive hormones modulate oxidative stress in Alzheimer's disease.

Mutations in progranulin explain atypical phenotypes with variants in MAPT.

B-vitamins reduce plasma levels of beta amyloid.

Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: a putative marker of an ongoing inflammatory process.

Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment.

Androgens in the etiology of Alzheimer's disease in aging men and possible therapeutic interventions.

Fluoro-2-deoxy-D-glucose (FDG)-PET in APOEepsilon4 carriers in the Australian population.

Gonadotropins and cognition in older women.

Infection and Alzheimer's disease: the APOE epsilon4 connection and lipid metabolism.

Luteinizing hormone levels are positively correlated with plasma amyloid-beta protein levels in elderly men.

Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease.

Distinct effects of testosterone on plasma and cerebrospinal fluid amyloid-beta levels.

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes.

Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity.

Association of cardiovascular factors and Alzheimer's disease plasma amyloid-beta protein in subjective memory complainers.

Androgens and Alzheimer's disease.

Abeta aggregation and possible implications in Alzheimer's disease pathogenesis.

The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease.

The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eepsilon4 carriers and non-carriers.

Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals.

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos.

Complex splicing and neural expression of duplicated tau genes in zebrafish embryos.

Predicting memory decline as a risk factor for Alzheimer's disease in older post-menopausal women: quod erat demonstrandum?

Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology.

Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.

The structure and function of Alzheimer's gamma secretase enzyme complex.

Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease.

Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry.

Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease.

Relationship between atrophy and beta-amyloid deposition in Alzheimer disease.

Plasma amyloid-beta as a biomarker in Alzheimer's disease: the AIBL study of aging.

Addressing population aging and Alzheimer's disease through the Australian imaging biomarkers and lifestyle study: collaboration with the Alzheimer's Disease Neuroimaging Initiative.

APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice.

Larger temporal volume in elderly with high versus low beta-amyloid deposition.

Ocular biomarkers for early detection of Alzheimer's disease.

Zebrafish as a tool in Alzheimer's disease research.

Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers.

Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease.

Effects of anticholinergic drugs on cognitive function in older Australians: results from the AIBL study.

A web-based normative data tool for assessing cognitive performance in healthy older Australians.

Advances in structural and molecular neuroimaging in Alzheimer's disease.

New lexicon and criteria for the diagnosis of Alzheimer's disease.

Memory function in a mouse genetic model of Alzheimer's disease.

Cognition and beta-amyloid in preclinical Alzheimer's disease: data from the AIBL study.

Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.

The dynamics of CD147 in Alzheimer's disease development and pathology.

Predictors of rapid cognitive decline in Alzheimer's disease: results from the Australian imaging, biomarkers and lifestyle (AIBL) study of ageing.

Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study.

Direct exposure of guinea pig CNS to human luteinizing hormone increases cerebrospinal fluid and cerebral beta amyloid levels.

Evaluation of color preference in zebrafish for learning and memory.

Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease.

Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study.

Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice.

Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.

Robust homeostasis of Presenilin1 protein levels by transcript regulation.

Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study.

Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease.

Latrepirdine (Dimebon™) Enhances Autophagy and Reduces Intracellular GFP-Aβ42 Levels in Yeast.

Pharmacological effects of cannabinoids on the reference and working memory functions in mice.

Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-β

Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial.

Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults.

Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network.