Laboratory for Microbiology
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Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'.
Journal of ethnopharmacology Jul, 2006 | Pubmed ID: 16698208
Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection - an update (1998 - 2007).
Planta medica Sep, 2008 | Pubmed ID: 18671200
In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences.
Antimicrobial agents and chemotherapy Sep, 2009 | Pubmed ID: 19546361
Infectivity of Giardia duodenalis Assemblages A and E for the gerbil and axenisation of duodenal trophozoites.
Parasitology international Dec, 2010 | Pubmed ID: 20696269
In vitro and in vivo prophylactic and curative activity of the triterpene saponin PX-6518 against cutaneous Leishmania species.
The Journal of antimicrobial chemotherapy Feb, 2011 | Pubmed ID: 21131319
An alternative, sensitive method to detect Helicobacter pylori DNA in feces.
Helicobacter Apr, 2011 | Pubmed ID: 21435088
Intrinsic susceptibility of Giardia duodenalis assemblage subtypes A(I), A(II), B and E(III) for nitric oxide under axenic culture conditions.
Parasitology research Mar, 2012 | Pubmed ID: 21894509
Evaluation of the anti-adhesive effect of milk fat globule membrane glycoproteins on Helicobacter pylori in the human NCI-N87 cell line and C57BL/6 mouse model.
Helicobacter Aug, 2012 | Pubmed ID: 22759332
Role of oxidative stress and apoptosis in the cellular response of murine macrophages upon Leishmania infection.
Parasitology Sep, 2012 | Pubmed ID: 22776404
Quantification of Candida albicans by flow cytometry using TO-PRO(®)-3 iodide as a single-stain viability dye.
Journal of microbiological methods Feb, 2013 | Pubmed ID: 23266389
Essential oil from Chenopodium ambrosioides and main components: activity against Leishmania, their mitochondria and other microorganisms.
Experimental parasitology Jan, 2014 | Pubmed ID: 24184772
Importance of biofilm formation and dipeptidyl peptidase IV for the pathogenicity of clinical Porphyromonas gingivalis isolates.
Pathogens and disease Apr, 2014 | Pubmed ID: 24532232
Pyrrolo[1,2-α][1,4]benzodiazepines show potent in vitro antifungal activity and significant in vivo efficacy in a Microsporum canis dermatitis model in guinea pigs.
The Journal of antimicrobial chemotherapy Jun, 2014 | Pubmed ID: 24535279
Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold.
ACS medicinal chemistry letters May, 2013 | Pubmed ID: 24900696
In vitro and in vivo activity of major constituents from Pluchea carolinensis against Leishmania amazonensis.
Parasitology research Aug, 2014 | Pubmed ID: 24906989
Animal models of invasive aspergillosis for drug discovery.
Drug discovery today Sep, 2014 | Pubmed ID: 24931219
Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in saudi and yemeni traditional medicine.
Evidence-based complementary and alternative medicine : eCAM , 2014 | Pubmed ID: 24963330
Flow cytometric enumeration of bacteria using TO-PRO®-3 iodide as a single-stain viability dye.
Journal of laboratory automation Dec, 2014 | Pubmed ID: 25124156
In vitro antiprotozoal and cytotoxic activity of ethnopharmacologically selected guinean plants.
Planta medica Oct, 2014 | Pubmed ID: 25180493
From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.
Bioorganic & medicinal chemistry Oct, 2014 | Pubmed ID: 25199582
Efficacy of oleylphosphocholine (OlPC) in vitro and in a mouse model of invasive aspergillosis.
Mycoses Mar, 2015 | Pubmed ID: 25590577
N-acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXR.
Bioorganic & medicinal chemistry letters Apr, 2015 | Pubmed ID: 25726328
Development of a novel in vitro onychomycosis model for the evaluation of topical antifungal activity.
Journal of microbiological methods May, 2015 | Pubmed ID: 25772040
The malaria co-infection challenge: An investigation into the antimicrobial activity of selected Guinean medicinal plants.
Journal of ethnopharmacology Nov, 2015 | Pubmed ID: 25773488
A flow cytometric approach to quantify biofilms.
Folia microbiologica Jul, 2015 | Pubmed ID: 25948317
Comparative Fitness of a Parent Leishmania donovani Clinical Isolate and Its Experimentally Derived Paromomycin-Resistant Strain.
PloS one , 2015 | Pubmed ID: 26469696
Antimicrobial Assessment of Resins from Calophyllum Antillanum and Calophyllum Inophyllum.
Phytotherapy research : PTR Dec, 2015 | Pubmed ID: 26514875
Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model.
PloS one , 2016 | Pubmed ID: 26848853
Evaluation of topical antifungal products in an in vitro onychomycosis model.
Mycoses May, 2016 | Pubmed ID: 26857689
Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.
Bioorganic & medicinal chemistry Apr, 2016 | Pubmed ID: 26935942
In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) Jan, 2017 | Pubmed ID: 26938501
Optimization and validation of an existing, surgical and robust dry eye rat model for the evaluation of therapeutic compounds.
Experimental eye research May, 2016 | Pubmed ID: 26995142
The role of the globin-coupled sensor YddV in a mature E. coli biofilm population.
Biochimica et biophysica acta Jul, 2016 | Pubmed ID: 27083533
Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.
PloS one , 2016 | Pubmed ID: 27123924
Characterizing the in vitro biofilm phenotype of Staphylococcus epidermidis isolates from central venous catheters.
Journal of microbiological methods Aug, 2016 | Pubmed ID: 27196636
Design, synthesis and biological evaluation of novel quinoline-based carboxylic hydrazides as anti-tubercular agents.
Chemical biology & drug design Oct, 2016 | Pubmed ID: 27203404
Phytochemical and Pharmacological Investigations on Nymphoides indica Leaf Extracts.
Phytotherapy research : PTR Oct, 2016 | Pubmed ID: 27282639
Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents.
Bioorganic & medicinal chemistry Nov, 2016 | Pubmed ID: 27614917
Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate.
Molecules (Basel, Switzerland) Sep, 2016 | Pubmed ID: 27681714
Triterpenoid Saponins from Maesa argentea Leaves.
Planta medica Dec, 2016 | Pubmed ID: 27737476
Comparative analysis of the internalization of the macrophage receptor sialoadhesin in human and mouse primary macrophages and cell lines.
Immunobiology Jun, 2017 | Pubmed ID: 27899210
Isolation and Structure Elucidation by LC-DAD-MS and LC-DAD-SPE-NMR of Cyclopeptide Alkaloids from the Roots of Ziziphus oxyphylla and Evaluation of Their Antiplasmodial Activity.
Journal of natural products Nov, 2016 | Pubmed ID: 27933893
Monoclonal antibody binding to the macrophage-specific receptor sialoadhesin alters the phagocytic properties of human and mouse macrophages.
Cellular immunology Feb, 2017 | Pubmed ID: 27993350
Antiplasmodial Activity, Cytotoxicity and Structure-Activity Relationship Study of Cyclopeptide Alkaloids.
Molecules (Basel, Switzerland) Feb, 2017 | Pubmed ID: 28157177
Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models.
PloS one , 2017 | Pubmed ID: 28248999
Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum.
PLoS neglected tropical diseases May, 2017 | Pubmed ID: 28505185
In vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds.
Toxicology in vitro : an international journal published in association with BIBRA Aug, 2017 | Pubmed ID: 28506817
Optimization and characterization of a murine lung infection model for the evaluation of novel therapeutics against Burkholderia cenocepacia.
Journal of microbiological methods Aug, 2017 | Pubmed ID: 28587856
Detection of Helicobacter pylori in the Gastric Mucosa by Fluorescence In Vivo Hybridization.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28600766
Design, synthesis and antitubercular potency of 4-hydroxyquinolin-2(1H)-ones.
European journal of medicinal chemistry Sep, 2017 | Pubmed ID: 28689097
Corrigenda to "Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents" [Bioorg Med Chem 24 (2016) 5172-5182].
Bioorganic & medicinal chemistry Oct, 2017 | Pubmed ID: 28826595
Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds.
Chemical biology & drug design Feb, 2018 | Pubmed ID: 28845550
Essential Oil from Piper aduncum: Chemical Analysis, Antimicrobial Assessment, and Literature Review.
Medicines (Basel, Switzerland) Jul, 2017 | Pubmed ID: 28930264
Bioassay-guided Study of the Antimicrobial and Cytotoxic Properties of the Leaves from Sw.
Pharmacognosy research , 2017 | Pubmed ID: 29263635
Microbial Community Dynamics during Rearing of Black Soldier Fly Larvae (Hermetia illucens) and Impact on Exploitation Potential.
Applied and environmental microbiology May, 2018 | Pubmed ID: 29475866
Oxidative stress and endothelial function in normal pregnancy versus pre-eclampsia, a combined longitudinal and case control study.
BMC pregnancy and childbirth Feb, 2018 | Pubmed ID: 29482567
Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.
Journal of medicinal chemistry Apr, 2018 | Pubmed ID: 29510037
UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes.
Data in brief Feb, 2018 | Pubmed ID: 29541660
Efficacy of Four spp. Extracts in an Animal Model of Cutaneous Leishmaniasis.
Medicines (Basel, Switzerland) Jun, 2018 | Pubmed ID: 29874837
Methodologies for and evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.
Microbial cell (Graz, Austria) 06, 2018 | Pubmed ID: 29992128
Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization.
Viruses Aug, 2018 | Pubmed ID: 30110893
Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function.
PloS one , 2018 | Pubmed ID: 30204759
Miltefosine enhances the fitness of a non-virulent drug-resistant Leishmania infantum strain.
The Journal of antimicrobial chemotherapy Feb, 2019 | Pubmed ID: 30412253
HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of .
Natural product research Apr, 2020 | Pubmed ID: 30602319
In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.
Journal of ethnopharmacology Oct, 2019 | Pubmed ID: 30763695
Antimicrobial activity of leaf extracts and isolated constituents of Croton linearis.
Journal of ethnopharmacology May, 2019 | Pubmed ID: 30849504
In vitro evaluation of arylsubstituted imidazoles derivatives as antiprotozoal agents and docking studies on sterol 14α-demethylase (CYP51) from Trypanosoma cruzi, Leishmania infantum, and Trypanosoma brucei.
Parasitology research May, 2019 | Pubmed ID: 30903349
Characterization of the role of N-glycosylation sites in the respiratory syncytial virus fusion protein in virus replication, syncytium formation and antigenicity.
Virus research Jun, 2019 | Pubmed ID: 31004621
Chemical Composition, Antimicrobial and Antiparasitic Screening of the Essential Oil from (Spreng.) Griseb.
Molecules (Basel, Switzerland) Apr, 2019 | Pubmed ID: 31022871
Opportunities for Overcoming Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy.
International journal of molecular sciences Jun, 2019 | Pubmed ID: 31212777
The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis.
European journal of medicinal chemistry Nov, 2019 | Pubmed ID: 31376569
Development and Characterization of New Species Cross-Reactive Anti-Sialoadhesin Monoclonal Antibodies.
Antibodies (Basel, Switzerland) Mar, 2016 | Pubmed ID: 31557988
1-(Piperidin-3-yl)thymine amides as inhibitors of thymidylate kinase.
Journal of enzyme inhibition and medicinal chemistry Dec, 2019 | Pubmed ID: 31822127
Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review.
Pharmaceutics Jun, 2020 | Pubmed ID: 32517052
Combination of Miconazole and Domiphen Bromide Is Fungicidal against Biofilms of Resistant spp.
Antimicrobial agents and chemotherapy Sep, 2020 | Pubmed ID: 32690639
3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency.
Materials (Basel, Switzerland) Jul, 2020 | Pubmed ID: 32751210
and Evaluation of Predicted Pneumococcal UDPG:PP Inhibitors.
Frontiers in microbiology , 2020 | Pubmed ID: 32760374
Antimicrobial investigation of ethnobotanically selected guinean plant species.
Journal of ethnopharmacology Dec, 2020 | Pubmed ID: 32768641
A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation.
Scientific reports Oct, 2020 | Pubmed ID: 33057006
Antioxidants in Plants: A Valorization Potential Emphasizing the Need for the Conservation of Plant Biodiversity in Cuba.
Antioxidants (Basel, Switzerland) Oct, 2020 | Pubmed ID: 33121046
Bioassay-guided isolation of antiplasmodial and antimicrobial constituents from the roots of Terminalia albida.
Journal of ethnopharmacology Mar, 2021 | Pubmed ID: 33246123
Essential Oil from : Antimicrobial, Antikinetoplastid, Antiproliferative and Cytotoxic Assessment.
Molecules (Basel, Switzerland) Nov, 2020 | Pubmed ID: 33255562
Minimum information guideline for spectrophotometric and fluorometric methods to assess biofilm formation in microplates.
Biofilm Dec, 2020 | Pubmed ID: 33447797
Phenols from L. and L. and their activity against carbonic anhydrase.
Natural product research Mar, 2022 | Pubmed ID: 33533668
Chemical and Pharmacological Potential of , an Endemic Endangered Plant from Cuba.
Molecules (Basel, Switzerland) Feb, 2021 | Pubmed ID: 33578815
Antiplasmodial Oleanane Triterpenoids from Root Bark.
Journal of natural products Mar, 2021 | Pubmed ID: 33667089
Anti-inflammatory effect of Adelia ricinella L. aerial parts.
The Journal of pharmacy and pharmacology Mar, 2021 | Pubmed ID: 33793832
Differential Induction Pattern Towards Classically Activated Macrophages in Response to an Immunomodulatory Extract from Mycelium.
Journal of fungi (Basel, Switzerland) Mar, 2021 | Pubmed ID: 33799778
Novel flavonol-3--methylethers from Griseb. (Rutaceae).
Natural product research Oct, 2022 | Pubmed ID: 33813981
Microbial symbionts of insects as a source of new antimicrobials: a review.
Critical reviews in microbiology Sep, 2021 | Pubmed ID: 34032192
Coupling Additive Manufacturing with Hot Melt Extrusion Technologies to Validate a Ventilator-Associated Pneumonia Mouse Model.
Pharmaceutics May, 2021 | Pubmed ID: 34064276
Interlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods.
Scientific reports 07, 2021 | Pubmed ID: 34215805
Can filaments, pellets and powder be used as feedstock to produce highly drug-loaded ethylene-vinyl acetate 3D printed tablets using extrusion-based additive manufacturing?
International journal of pharmaceutics Sep, 2021 | Pubmed ID: 34303815
Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors.
European journal of medicinal chemistry Dec, 2021 | Pubmed ID: 34450493
Antifungal Activity of Extracts, Fractions, and Constituents from Leaves.
Pharmaceuticals (Basel, Switzerland) Sep, 2021 | Pubmed ID: 34577616
Evaluation of Antimicrobial Peptides from the Black Soldier Fly () against a Selection of Human Pathogens.
Microbiology spectrum Feb, 2022 | Pubmed ID: 34985302
LC-MS Characterization and Biological Activities of Cuban Cultivars of Schltr.
Plants (Basel, Switzerland) Jan, 2022 | Pubmed ID: 35009137
Semisynthetic triterpenes led to the generation of selective antitrypanosomal lead compounds.
Chemical biology & drug design Jun, 2022 | Pubmed ID: 35313075
Pharmacological Screening of Essential Oils from and Growing in Brazil.
Molecules (Basel, Switzerland) Mar, 2022 | Pubmed ID: 35335288
Antiplasmodial activity of alkaloids from Croton linearis leaves.
Experimental parasitology , 2022 | Pubmed ID: 35378134
A Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection.
Scientific reports Jul, 2022 | Pubmed ID: 35854044
3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related Infection in Mice.
Pharmaceutics Jun, 2022 | Pubmed ID: 35890261
Inhibition of Bacterial Adhesion and Biofilm Formation by Seed-Derived Ethanol Extracts from Mill.
Molecules (Basel, Switzerland) Aug, 2022 | Pubmed ID: 35956958
Inhibitory Effect on Nitric Oxide Release in LPS-Stimulated Macrophages and Free Radical Scavenging Activity of Jacq. Leaves.
Antioxidants (Basel, Switzerland) Sep, 2022 | Pubmed ID: 36290638
Antibiotic Tolerance Indicative of Persistence Is Pervasive among Clinical Streptococcus pneumoniae Isolates and Shows Strong Condition Dependence.
Microbiology spectrum Dec, 2022 | Pubmed ID: 36374111
Selected strategies to fight pathogenic bacteria.
Journal of enzyme inhibition and medicinal chemistry Dec, 2023 | Pubmed ID: 36629427
Development and validation of a multiplex electrochemiluminescence immunoassay to evaluate dry eye disease in rat tear fluids.
Scientific reports Jul, 2023 | Pubmed ID: 37500810
Phytochemical characterization and antifungal potential of leaf extracts of .
Natural product research Oct, 2024 | Pubmed ID: 37548293
In-depth biological characterization of two black soldier fly anti- peptides reveals LPS-binding and immunomodulating effects.
mSphere Oct, 2023 | Pubmed ID: 37800918
Expanding the squaramide library as mycobacterial ATP synthase inhibitors: Innovative synthetic pathway and biological evaluation.
Bioorganic & medicinal chemistry Nov, 2023 | Pubmed ID: 37871508
In vitro modelling of bacterial pneumonia: a comparative analysis of widely applied complex cell culture models.
FEMS microbiology reviews Mar, 2024 | Pubmed ID: 38409952
The Liebeskind-Srogl Cross-Coupling Reaction as a Crucial Step in the Synthesis of New Squaramide-Based Antituberculosis Agents.
ACS omega Aug, 2024 | Pubmed ID: 39157083
Characterization of novel double-reporter strains of for drug discovery: a study in mScarlet.
Microbiology spectrum Oct, 2024 | Pubmed ID: 39189762
Polymyxin B Peptide Hydrogel Coating: A Novel Approach to Prevent Ventilator-Associated Pneumonia.
International journal of molecular sciences Sep, 2024 | Pubmed ID: 39408597
Gabriel S. Oliveira1,2,
Clara M. Bento1,3,4,
António Pombinho1,3,
Rita Reis1,3,
Kevin Van Calster5,6,
Linda De Vooght5,
André F. Maia1,3,
Paul Cos5,
Maria Salomé Gomes1,2,
Tânia Silva1,2
1, i3S – Instituto de Investigação e Inovação em Saúde da Universidade do Porto,
2, ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto,
3, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto,
4Programa Doutoral em Biologia Molecular e Celular (MCBiology), Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto,
5Laboratory for Microbiology, Parasitology and Hygiene (LMPH),
6Department of Infectious Diseases in Humans, Immune Response, Sciensano
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