Paul Cos

Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'.

Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection - an update (1998 - 2007).

In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences.

Infectivity of Giardia duodenalis Assemblages A and E for the gerbil and axenisation of duodenal trophozoites.

In vitro and in vivo prophylactic and curative activity of the triterpene saponin PX-6518 against cutaneous Leishmania species.

An alternative, sensitive method to detect Helicobacter pylori DNA in feces.

Intrinsic susceptibility of Giardia duodenalis assemblage subtypes A(I), A(II), B and E(III) for nitric oxide under axenic culture conditions.

Evaluation of the anti-adhesive effect of milk fat globule membrane glycoproteins on Helicobacter pylori in the human NCI-N87 cell line and C57BL/6 mouse model.

Role of oxidative stress and apoptosis in the cellular response of murine macrophages upon Leishmania infection.

Quantification of Candida albicans by flow cytometry using TO-PRO(®)-3 iodide as a single-stain viability dye.

Essential oil from Chenopodium ambrosioides and main components: activity against Leishmania, their mitochondria and other microorganisms.

Importance of biofilm formation and dipeptidyl peptidase IV for the pathogenicity of clinical Porphyromonas gingivalis isolates.

Pyrrolo[1,2-α][1,4]benzodiazepines show potent in vitro antifungal activity and significant in vivo efficacy in a Microsporum canis dermatitis model in guinea pigs.

Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold.

In vitro and in vivo activity of major constituents from Pluchea carolinensis against Leishmania amazonensis.

Animal models of invasive aspergillosis for drug discovery.

Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in saudi and yemeni traditional medicine.

Flow cytometric enumeration of bacteria using TO-PRO®-3 iodide as a single-stain viability dye.

In vitro antiprotozoal and cytotoxic activity of ethnopharmacologically selected guinean plants.

From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.

Efficacy of oleylphosphocholine (OlPC) in vitro and in a mouse model of invasive aspergillosis.

N-acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXR.

Development of a novel in vitro onychomycosis model for the evaluation of topical antifungal activity.

The malaria co-infection challenge: An investigation into the antimicrobial activity of selected Guinean medicinal plants.

A flow cytometric approach to quantify biofilms.

Comparative Fitness of a Parent Leishmania donovani Clinical Isolate and Its Experimentally Derived Paromomycin-Resistant Strain.

Antimicrobial Assessment of Resins from Calophyllum Antillanum and Calophyllum Inophyllum.

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model.

Evaluation of topical antifungal products in an in vitro onychomycosis model.

Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.

In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis.

Optimization and validation of an existing, surgical and robust dry eye rat model for the evaluation of therapeutic compounds.

The role of the globin-coupled sensor YddV in a mature E. coli biofilm population.

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.

Characterizing the in vitro biofilm phenotype of Staphylococcus epidermidis isolates from central venous catheters.

Design, synthesis and biological evaluation of novel quinoline-based carboxylic hydrazides as anti-tubercular agents.

Phytochemical and Pharmacological Investigations on Nymphoides indica Leaf Extracts.

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents.

Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate.

Triterpenoid Saponins from Maesa argentea Leaves.

Comparative analysis of the internalization of the macrophage receptor sialoadhesin in human and mouse primary macrophages and cell lines.

Isolation and Structure Elucidation by LC-DAD-MS and LC-DAD-SPE-NMR of Cyclopeptide Alkaloids from the Roots of Ziziphus oxyphylla and Evaluation of Their Antiplasmodial Activity.

Monoclonal antibody binding to the macrophage-specific receptor sialoadhesin alters the phagocytic properties of human and mouse macrophages.

Antiplasmodial Activity, Cytotoxicity and Structure-Activity Relationship Study of Cyclopeptide Alkaloids.

Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models.

Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum.

In vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds.

Optimization and characterization of a murine lung infection model for the evaluation of novel therapeutics against Burkholderia cenocepacia.

Detection of Helicobacter pylori in the Gastric Mucosa by Fluorescence In Vivo Hybridization.

Design, synthesis and antitubercular potency of 4-hydroxyquinolin-2(1H)-ones.

Corrigenda to "Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents" [Bioorg Med Chem 24 (2016) 5172-5182].

Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds.

Essential Oil from Piper aduncum: Chemical Analysis, Antimicrobial Assessment, and Literature Review.

Bioassay-guided Study of the Antimicrobial and Cytotoxic Properties of the Leaves from Sw.

Microbial Community Dynamics during Rearing of Black Soldier Fly Larvae (Hermetia illucens) and Impact on Exploitation Potential.

Oxidative stress and endothelial function in normal pregnancy versus pre-eclampsia, a combined longitudinal and case control study.

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.

UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes.

Efficacy of Four spp. Extracts in an Animal Model of Cutaneous Leishmaniasis.

Methodologies for and evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization.

Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function.

Miltefosine enhances the fitness of a non-virulent drug-resistant Leishmania infantum strain.

HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of .

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

Antimicrobial activity of leaf extracts and isolated constituents of Croton linearis.

In vitro evaluation of arylsubstituted imidazoles derivatives as antiprotozoal agents and docking studies on sterol 14α-demethylase (CYP51) from Trypanosoma cruzi, Leishmania infantum, and Trypanosoma brucei.

Characterization of the role of N-glycosylation sites in the respiratory syncytial virus fusion protein in virus replication, syncytium formation and antigenicity.

Chemical Composition, Antimicrobial and Antiparasitic Screening of the Essential Oil from (Spreng.) Griseb.

Opportunities for Overcoming Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy.

The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis.

Development and Characterization of New Species Cross-Reactive Anti-Sialoadhesin Monoclonal Antibodies.

1-(Piperidin-3-yl)thymine amides as inhibitors of thymidylate kinase.

Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review.

Combination of Miconazole and Domiphen Bromide Is Fungicidal against Biofilms of Resistant spp.

3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency.

and Evaluation of Predicted Pneumococcal UDPG:PP Inhibitors.

Antimicrobial investigation of ethnobotanically selected guinean plant species.

A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation.

Antioxidants in Plants: A Valorization Potential Emphasizing the Need for the Conservation of Plant Biodiversity in Cuba.

Bioassay-guided isolation of antiplasmodial and antimicrobial constituents from the roots of Terminalia albida.

Essential Oil from : Antimicrobial, Antikinetoplastid, Antiproliferative and Cytotoxic Assessment.

Minimum information guideline for spectrophotometric and fluorometric methods to assess biofilm formation in microplates.

Phenols from L. and L. and their activity against carbonic anhydrase.

Chemical and Pharmacological Potential of , an Endemic Endangered Plant from Cuba.

Antiplasmodial Oleanane Triterpenoids from Root Bark.

Anti-inflammatory effect of Adelia ricinella L. aerial parts.

Differential Induction Pattern Towards Classically Activated Macrophages in Response to an Immunomodulatory Extract from Mycelium.

Novel flavonol-3--methylethers from Griseb. (Rutaceae).

Microbial symbionts of insects as a source of new antimicrobials: a review.

Coupling Additive Manufacturing with Hot Melt Extrusion Technologies to Validate a Ventilator-Associated Pneumonia Mouse Model.

Interlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods.

Can filaments, pellets and powder be used as feedstock to produce highly drug-loaded ethylene-vinyl acetate 3D printed tablets using extrusion-based additive manufacturing?

Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors.

Antifungal Activity of Extracts, Fractions, and Constituents from Leaves.

Evaluation of Antimicrobial Peptides from the Black Soldier Fly () against a Selection of Human Pathogens.

LC-MS Characterization and Biological Activities of Cuban Cultivars of Schltr.

Semisynthetic triterpenes led to the generation of selective antitrypanosomal lead compounds.

Pharmacological Screening of Essential Oils from and Growing in Brazil.

Antiplasmodial activity of alkaloids from Croton linearis leaves.

A Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection.

3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related Infection in Mice.

Inhibition of Bacterial Adhesion and Biofilm Formation by Seed-Derived Ethanol Extracts from Mill.

Inhibitory Effect on Nitric Oxide Release in LPS-Stimulated Macrophages and Free Radical Scavenging Activity of Jacq. Leaves.

Antibiotic Tolerance Indicative of Persistence Is Pervasive among Clinical Streptococcus pneumoniae Isolates and Shows Strong Condition Dependence.

Selected strategies to fight pathogenic bacteria.

Development and validation of a multiplex electrochemiluminescence immunoassay to evaluate dry eye disease in rat tear fluids.

Phytochemical characterization and antifungal potential of leaf extracts of .

In-depth biological characterization of two black soldier fly anti- peptides reveals LPS-binding and immunomodulating effects.

Expanding the squaramide library as mycobacterial ATP synthase inhibitors: Innovative synthetic pathway and biological evaluation.

In vitro modelling of bacterial pneumonia: a comparative analysis of widely applied complex cell culture models.

The Liebeskind-Srogl Cross-Coupling Reaction as a Crucial Step in the Synthesis of New Squaramide-Based Antituberculosis Agents.

Characterization of novel double-reporter strains of for drug discovery: a study in mScarlet.

Polymyxin B Peptide Hydrogel Coating: A Novel Approach to Prevent Ventilator-Associated Pneumonia.