Chuan He

A Short Copper-Copper Distance in a (µ-1,2-Peroxo)dicopper(II) Complex Having a 1,8-Naphthyridine Unit as an Additional Bridge This work was supported by grants from the National Science Foundation and the National Institutes of Health. We thank A. M. Barrios for help in acquiring resonance Raman spectra. X-ray absorption spectroscopic data were measured at SSRL. SSRL is funded by the Department of Energy, Office of Basic Energy Science. The SSRL Structural Molecular Biology Program is supported by the National Institute of Health, National Center for Research Resources, Biomedical Technology Program, and by the Department of Energy, Office of Biological and Environmental Research.

Osteogenic potential of rabbit marrow stromal stem cells cultured in vitro: a histochemical and scanning electron microscopic study.

Trapping distinct structural states of a protein/DNA interaction through disulfide crosslinking.

Converting the sacrificial DNA repair protein N-ada into a catalytic methyl phosphotriester repair enzyme.

Probing the structure and function of the Escherichia coli DNA alkylation repair AlkB protein through chemical cross-linking.

[Experiment on fibroblast-PGA complexes cultured in rotary cell culture system].

How do DNA repair proteins locate potential base lesions? a chemical crosslinking method to investigate O6-alkylguanine-DNA alkyltransferases.

Efficient aziridination of olefins catalyzed by a unique disilver(I) compound.

A general strategy to convert the MerR family proteins into highly sensitive and selective fluorescent biosensors for metal ions.

Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.

Modeling non-heme iron proteins.

An Au-catalyzed cyclialkylation of electron-rich arenes with epoxides to prepare 3-chromanols.

Efficient functionalization of aromatic C-H bonds catalyzed by gold(III) under mild and solvent-free conditions.

A silver-catalyzed intramolecular amidation of saturated C--h bonds.

Direct functionalization of arenes by primary alcohol sulfonate esters catalyzed by gold(III).

Preparation and characterization of the native iron(II)-containing DNA repair AlkB protein directly from Escherichia coli.

An exceptionally selective lead(II)-regulatory protein from Ralstonia metallidurans: development of a fluorescent lead(II) probe.

Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury.

Gold(I)-catalyzed intermolecular addition of phenols and carboxylic acids to olefins.

[Regulation of calcium-activated potassium channels of mesenteric artery smooth muscle from patients with essential hypertension by endothelin-1 and prostagl E1].

The structure of the human AGT protein bound to DNA and its implications for damage detection.

Intramolecular additions of alcohols and carboxylic acids to inert olefins catalyzed by silver(I) triflate.

A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada.

Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins.

Efficient gold-catalyzed hydroamination of 1,3-dienes.

Direct reversal of DNA alkylation damage.

Gold(I)-catalyzed intra- and intermolecular hydroamination of unactivated olefins.

Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.

Mechanistic principles of nanoparticle evolution to zeolite crystals.

[Experiment on induction of fibroblasts on 3-D cell-foam structures to express osteoblastic phenotype and its mechanism].

Nitrene transfer reactions catalyzed by gold complexes.

Brønsted acid catalyzed addition of phenols, carboxylic acids, and tosylamides to simple olefins.

An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus.

Design of an emission ratiometric biosensor from MerR family proteins: a sensitive and selective sensor for Hg2+.

Silver-catalyzed intermolecular amination of C--H groups.

Gold(III)-catalyzed nitrene insertion into aromatic and benzylic C-H groups.

Engineered holliday junctions as single-molecule reporters for protein-DNA interactions with application to a MerR-family regulator.

Spectroscopic insights into lead(II) coordination by the selective lead(II)-binding protein PbrR691.

Diazirine-based DNA photo-cross-linking probes for the study of protein-DNA interactions.

Synthesis of photoactive analogues of a cystine knot trypsin inhibitor protein.

Ni-catalyzed mild arylation of alpha-halocarbonyl compounds with arylboronic acids.

A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli.

Selective recognition of metal ions by metalloregulatory proteins.

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.

Aryl halide tolerated electrophilic amination of arylboronic acids with N-chloroamides catalyzed by CuCl at room temperature.

Gold-catalyzed organic transformations.

A small molecule enhances RNA interference and promotes microRNA processing.

The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism.

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.

Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells.

A diazirine-based nucleoside analogue for efficient DNA interstrand photocross-linking.

[The online measurement for pulp Kappa number based on near infrared spectroscopy and support vector machine].

A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus.

Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin.

[Attachment sites and receptors of hepatitis B virus].

[Safety and efficiency of pacing at right ventricular outflow versus at ventricular cardiac apex].

Nickel-catalyzed oxidative coupling reactions of two different terminal alkynes using O(2) as the oxidant at room temperature: facile syntheses of unsymmetric 1,3-diynes.

A new 1'-methylenedisulfide deoxyribose that forms an efficient cross-link to DNA cytosine-5 methyltransferase (DNMT).

Damage detection and base flipping in direct DNA alkylation repair.

Engineering a uranyl-specific binding protein from NikR.

使用流从偏见澄清滑动的单个 DNA 修复蛋白和与 DNA 的相互作用。

[A clinical trial for homoharringtonine and low-dose cytosine arabinoside combined with G-CSF or GM-CSF to treat the relapsed or refractory acute myeloid leukemia (AML), geriatric AML and advanced myelodysplastic syndromes].

Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism.

Platinum(II)-catalyzed intramolecular cyclization of o-substituted aryl alkynes through sp3 C-H activation.

[Molecular cloning and expression of alcohol dehydrogenase gene of Phanerochaete chrysosporium].

Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus.

Highly sensitive and selective gold(I) recognition by a metalloregulator in Ralstonia metallidurans.

[Studies on chemical constituents from herbs of Usnea longissima].

Chemical methods to study protein-nucleic acid interactions.

A non-heme iron-mediated chemical demethylation in DNA and RNA.

Intramolecular amide bonds stabilize pili on the surface of bacilli.

Results of selective hip arthroplasty revision in isolated acetabular failure.

Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection.

Liquid chromatography/mass spectrometry analysis of perfluoroalkyl carboxylic acids and perfluorooctanesulfonate in bivalve shells: extraction method optimization.

Hydroxyl ammonium ionic liquids synthesized by water-bath microwave: synthesis and desulfurization.

Perimedullary arteriovenous fistulas in pediatric patients: clinical, angiographical, and therapeutic experiences in a series of 19 cases.

Dynamic copper(I) imaging in mammalian cells with a genetically encoded fluorescent copper(I) sensor.

In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS.

The highways and byways of bioinorganic chemistry.

Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system.

Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus.

Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs.

Copper catalyzed arylation/C-C bond activation: an approach toward alpha-aryl ketones.

CcpA mediates proline auxotrophy and is required for Staphylococcus aureus pathogenesis.

Redox signaling in human pathogens.

The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA.

Emergence of chemical biology approaches to the RNAi/miRNA pathway.

Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR.

Organocatalysis in cross-coupling: DMEDA-catalyzed direct C-H arylation of unactivated benzene.

Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.

Grand challenge commentary: RNA epigenetics?

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.

The tightly regulated copper window in yeast.

catena-Poly[[tetra-aqua-zinc(II)]-μ-1,3,4-thia-diazol-2,5-diyldithio-diacetato-κO:O'].

Aureusimines in Staphylococcus aureus are not involved in virulence.

Sensing and control of flow separation using plasma actuators.

Syntheses of two 5-hydroxymethyl-2'-deoxycytidine phosphoramidites with TBDMS as the 5-hydroxymethyl protecting group and their incorporation into DNA.

Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(α)I.

Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes.

Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states.

Poly[[[diaqua-cobalt(II)]-bis-[μ(2)-1,1'-(butane-1,4-di-yl)diimidazole-κN:N]] dinitrate].

Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA.

Impact of carbondiimide crosslinker used for magnetic carbon nanotube mediated GFP plasmid delivery.

Detection of 5-hydroxymethylcytosine in DNA by transferring a keto-glucose by using T4 phage β-glucosyltransferase.

Preliminary clinical and radiographic results of large ceramic heads on highly cross-linked polyethylene.

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.

Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells.

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.

Structural and biochemical characterization of N5-carboxyaminoimidazole ribonucleotide synthetase and N5-carboxyaminoimidazole ribonucleotide mutase from Staphylococcus aureus.

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.

Selective recognition of americium by peptide-based reagents.

Binding of ReO4(-) with an engineered MoO4(2-)-binding protein: towards a new approach in radiopharmaceutical applications.

Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.

The association between infants' self-regulatory behavior and MAOA gene polymorphism.

Near-infrared light emission from a GaN/Si nanoheterostructure array.

Gold(I)-catalyzed formation of 3-pyrazolines through cycloaddition of diaziridine to alkynes.

Selective fluorescent probes for live-cell monitoring of sulphide.

N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.

Studies of vascular endothelial growth factor in asthma and chronic obstructive pulmonary disease.

Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine.

AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus.

Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.

The hunt for 5-hydroxymethylcytosine: the sixth base.

A proteomic approach to identification of plutonium-binding proteins in mammalian cells.

Preparation of DNA containing 5-hydroxymethyl-2'-deoxycytidine modification through phosphoramidites with TBDMS as 5-hydroxymethyl protecting group.

A novel haemodynamic cerebral aneurysm model of rats with normal blood pressure.

Exploring the cell uptake mechanism of phospholipid and polyethylene glycol coated gold nanoparticles.

Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus.

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.

Differential function of lip residues in the mechanism and biology of an anthrax hemophore.

Effect of annealing treatment on electroluminescence from GaN/Si nanoheterostructure array.

A novel intravital method to evaluate cerebral vasospasm in rat models of subarachnoid hemorrhage: a study with synchrotron radiation angiography.

Silver-mediated oxidative C-H/C-H functionalization: a strategy to construct polysubstituted furans.

Elevated plasma levels of endostatin are associated with chronic kidney disease.

Heterologous expression and purification of Arabidopsis thaliana VIM1 protein: In vitro evidence for its inability to recognize hydroxymethylcytosine, a rare base in Arabidopsis DNA.

[Preliminary clinical evaluations of panipenem-betamipron in the treatment of hematological malignancy infections].

The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression.

SN-38 loaded polymeric micelles to enhance cancer therapy.

Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response.

Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA.

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.

Isopeptide bonds of the major pilin protein BcpA influence pilus structure and bundle formation on the surface of Bacillus cereus.

Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2.

Duplex interrogation by a direct DNA repair protein in search of base damage.

Synthesis of DNA oligos containing 2'-deoxy-2'-fluoro-D-arabinofuranosyl-5-carboxylcytosine as hTDG inhibitor.

Panorama of DNA hairpin folding observed via diffusion-decelerated fluorescence correlation spectroscopy.

Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses.

5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription.

Organocatalytic Asymmetric Direct C sp 3H Functionalization of Ethers: A Highly Efficient Approach to Chiral Spiroethers.

The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus.

Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.

A selective fluorescent probe for carbon monoxide imaging in living cells.

Rational Design of a Palladium-Catalyzed C(sp) -C(sp) Cross-Coupling Reaction Inspired by Kinetic Studies.

De novo multiple dural arteriovenous fistulas and arteriovenous malformation after embolization of cerebral arteriovenous fistula: case report.

The oxidation-sensing regulator (MosR) is a new redox dependent transcription factor in Mycobacterium tuberculosis.

Heteroaromatic imidazo[1,2-a]pyridines synthesis from C-H/N-H oxidative cross-coupling/cyclization.

Spatiotemporal clustering of epigenome reveals rules of dynamic gene regulation.