Department of Tumor Immunology,
Nijmegen Center for Molecular Life Sciences,
Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences
Carl G. Figdor has not added Biography.
If you are Carl G. Figdor and would like to personalize this page please email our Author Liaison for assistance.
Regulation of LFA-1 Expression by CD34 Positive Cells and Inducible Growth Factor Production by Stroma Enable Formation of Bone Marrow Compartments; Subject Heading.
Hematology (Amsterdam, Netherlands) , 2000 | Pubmed ID: 11399626
Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1.
The Journal of biological chemistry Mar, 2002 | Pubmed ID: 11799126
The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2002 | Pubmed ID: 11859097
C-type lectin receptors on dendritic cells and Langerhans cells.
Nature reviews. Immunology Feb, 2002 | Pubmed ID: 11910898
Enhancement of G-CSF-induced stem cell mobilization by antibodies against the beta 2 integrins LFA-1 and Mac-1.
Blood Jul, 2002 | Pubmed ID: 12070044
Renal cell carcinoma-associated antigen G250 encodes a naturally processed epitope presented by human leukocyte antigen-DR molecules to CD4(+) T lymphocytes.
International journal of cancer. Journal international du cancer Aug, 2002 | Pubmed ID: 12115527
The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion.
The Journal of biological chemistry Aug, 2002 | Pubmed ID: 12171996
Phenotypical and functional characterization of clinical grade dendritic cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) Sep-Oct, 2002 | Pubmed ID: 12218781
Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state.
Cancer research Jan, 2003 | Pubmed ID: 12517769
Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cells.
Arthritis and rheumatism Feb, 2003 | Pubmed ID: 12571844
Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2003 | Pubmed ID: 12574392
The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells.
European journal of immunology Feb, 2003 | Pubmed ID: 12645952
The heme-heme oxygenase system: a molecular switch in wound healing.
Blood Jul, 2003 | Pubmed ID: 12649161
Different faces of the heme-heme oxygenase system in inflammation.
Pharmacological reviews Sep, 2003 | Pubmed ID: 12869663
Analysis of dendritic cell trafficking using EGFP-transgenic mice.
Immunology letters Oct, 2003 | Pubmed ID: 12946860
Ceramic hydroxyapatite coating on titanium implants drives selective bone marrow stromal cell adhesion.
Clinical oral implants research Oct, 2003 | Pubmed ID: 12969360
An automated multi well cell track system to study leukocyte migration.
Journal of immunological methods Sep, 2003 | Pubmed ID: 12972190
Dual function of C-type lectin-like receptors in the immune system.
Current opinion in cell biology Oct, 2003 | Pubmed ID: 14519388
Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research Nov, 2003 | Pubmed ID: 14613986
Presence and localization of T-cell subsets in relation to melanocyte differentiation antigen expression and tumour regression as assessed by immunohistochemistry and molecular analysis of microdissected T cells.
The Journal of pathology Jan, 2004 | Pubmed ID: 14694523
Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells.
The Journal of cell biology Jan, 2004 | Pubmed ID: 14709546
Dendritic cell immunotherapy: mapping the way.
Nature medicine May, 2004 | Pubmed ID: 15122249
Differentiating stem cells mask their origins.
Stem cells (Dayton, Ohio) , 2004 | Pubmed ID: 15153601
Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases.
Journal of cell science Jun, 2004 | Pubmed ID: 15169840
In situ tumor ablation creates an antigen source for the generation of antitumor immunity.
Cancer research Jun, 2004 | Pubmed ID: 15173017
Phenotypical and functional characterization of clinical-grade dendritic cells.
Methods in molecular medicine , 2005 | Pubmed ID: 15585917
The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum.
Journal of leukocyte biology Mar, 2005 | Pubmed ID: 15601667
Novel monoclonal antibodies detect elevated levels of the chemokine CCL18/DC-CK1 in serum and body fluids in pathological conditions.
Journal of leukocyte biology May, 2005 | Pubmed ID: 15713699
How C-type lectins detect pathogens.
Cellular microbiology Apr, 2005 | Pubmed ID: 15760448
Migration of dendritic cell based cancer vaccines: in vivo veritas?
Current opinion in immunology Apr, 2005 | Pubmed ID: 15766677
"Sweet talk": closing in on C type lectin signaling.
Immunity Apr, 2005 | Pubmed ID: 15845444
Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody.
Blood Aug, 2005 | Pubmed ID: 15878980
Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints.
Arthritis and rheumatism May, 2005 | Pubmed ID: 15880344
Levels of complexity in pathogen recognition by C-type lectins.
Current opinion in immunology Aug, 2005 | Pubmed ID: 15950451
Immunomonitoring tumor-specific T cells in delayed-type hypersensitivity skin biopsies after dendritic cell vaccination correlates with clinical outcome.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Aug, 2005 | Pubmed ID: 16110035
Dendritic cells: tools and targets for antitumor vaccination.
Expert review of vaccines Oct, 2005 | Pubmed ID: 16221071
Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy.
Nature biotechnology Nov, 2005 | Pubmed ID: 16258544
Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.
Blood Apr, 2006 | Pubmed ID: 16352806
TRPM7, a novel regulator of actomyosin contractility and cell adhesion.
The EMBO journal Jan, 2006 | Pubmed ID: 16407977
Development of 111In-labeled tumor-associated antigen peptides for monitoring dendritic-cell-based vaccination.
Nuclear medicine and biology May, 2006 | Pubmed ID: 16720236
Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after Fc gamma RII-mediated uptake.
The Journal of experimental medicine Jul, 2006 | Pubmed ID: 16785312
A critical role for prostaglandin E2 in podosome dissolution and induction of high-speed migration during dendritic cell maturation.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2006 | Pubmed ID: 16849464
Synergy between in situ cryoablation and TLR9 stimulation results in a highly effective in vivo dendritic cell vaccine.
Cancer research Jul, 2006 | Pubmed ID: 16849578
Organization of the integrin LFA-1 in nanoclusters regulates its activity.
Molecular biology of the cell Oct, 2006 | Pubmed ID: 16855029
C-type lectins on dendritic cells and their interaction with pathogen-derived and endogenous glycoconjugates.
Current protein & peptide science Aug, 2006 | Pubmed ID: 16918443
Targeting antigens to dendritic cells in vivo.
Immunobiology , 2006 | Pubmed ID: 16920498
Cancer-germline gene expression in pediatric solid tumors using quantitative real-time PCR.
International journal of cancer. Journal international du cancer Jan, 2007 | Pubmed ID: 17019710
Relevance of DC-SIGN in DC-induced T cell proliferation.
Journal of leukocyte biology Mar, 2007 | Pubmed ID: 17135574
Sensitivity of magnetic resonance imaging of dendritic cells for in vivo tracking of cellular cancer vaccines.
International journal of cancer. Journal international du cancer Mar, 2007 | Pubmed ID: 17163419
Binding of the adhesion and pathogen receptor DC-SIGN by monocytes is regulated by the density of Lewis X molecules.
Molecular immunology Mar, 2007 | Pubmed ID: 17175026
Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2007 | Pubmed ID: 17182550
Myosin II and mechanotransduction: a balancing act.
Trends in cell biology Apr, 2007 | Pubmed ID: 17320396
Ligand-conjugated quantum dots monitor antigen uptake and processing by dendritic cells.
Nano letters Apr, 2007 | Pubmed ID: 17388641
Phenotypic and functional characterization of mature dendritic cells from pediatric cancer patients.
Pediatric blood & cancer Dec, 2007 | Pubmed ID: 17486645
Nanoscale organization of the pathogen receptor DC-SIGN mapped by single-molecule high-resolution fluorescence microscopy.
Chemphyschem : a European journal of chemical physics and physical chemistry Jul, 2007 | Pubmed ID: 17577901
Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting.
Nature reviews. Immunology Oct, 2007 | Pubmed ID: 17853902
In vivo targeting of DC-SIGN-positive antigen-presenting cells in a nonhuman primate model.
Journal of immunotherapy (Hagerstown, Md. : 1997) Oct, 2007 | Pubmed ID: 17893563
Distinct kinetic and mechanical properties govern ALCAM-mediated interactions as shown by single-molecule force spectroscopy.
Journal of cell science Nov, 2007 | Pubmed ID: 17971418
Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.
Blood Apr, 2008 | Pubmed ID: 18258799
Monocyte cell surface glycosaminoglycans positively modulate IL-4-induced differentiation toward dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2008 | Pubmed ID: 18322173
Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration.
Cancer immunology, immunotherapy : CII Nov, 2008 | Pubmed ID: 18322684
PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA-Rho-kinase axis.
Journal of cell science Apr, 2008 | Pubmed ID: 18334555
Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.
PloS one , 2008 | Pubmed ID: 18365021
Interaction of acute lymphopblastic leukemia cells with C-type lectins DC-SIGN and L-SIGN.
Experimental hematology Jul, 2008 | Pubmed ID: 18375037
Human and murine model cell lines for dendritic cell biology evaluated.
Immunology letters May, 2008 | Pubmed ID: 18384885
Vaccine-specific local T cell reactivity in immunotherapy-associated vitiligo in melanoma patients.
Cancer immunology, immunotherapy : CII Jan, 2009 | Pubmed ID: 18392619
TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.
Journal of molecular biology May, 2008 | Pubmed ID: 18394644
Selective cancer-germline gene expression in pediatric brain tumors.
Journal of neuro-oncology Jul, 2008 | Pubmed ID: 18398575
Dendritic cell interaction with Candida albicans critically depends on N-linked mannan.
The Journal of biological chemistry Jul, 2008 | Pubmed ID: 18482990
No advantage of cell-penetrating peptides over receptor-specific antibodies in targeting antigen to human dendritic cells for cross-presentation.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2008 | Pubmed ID: 18490772
Maximizing dendritic cell migration in cancer immunotherapy.
Expert opinion on biological therapy Jul, 2008 | Pubmed ID: 18549318
In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy.
Cancer research Jul, 2008 | Pubmed ID: 18593941
The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.
FEBS letters Sep, 2008 | Pubmed ID: 18675813
Activation of human plasmacytoid dendritic cells by TLR9 impairs Fc gammaRII-mediated uptake of immune complexes and presentation by MHC class II.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2008 | Pubmed ID: 18832675
Mesenchymal stromal cells: tissue engineers and immune response modulators.
Archivum immunologiae et therapiae experimentalis Sep-Oct, 2008 | Pubmed ID: 18836860
Polyinosinic polycytidylic acid prevents efficient antigen expression after mRNA electroporation of clinical grade dendritic cells.
Cancer immunology, immunotherapy : CII Jul, 2009 | Pubmed ID: 19018531
DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production.
Journal of leukocyte biology Mar, 2009 | Pubmed ID: 19028959
In vivo recruitment of hematopoietic cells using stromal cell-derived factor 1 alpha-loaded heparinized three-dimensional collagen scaffolds.
Tissue engineering. Part A Jul, 2009 | Pubmed ID: 19108679
The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity.
PLoS pathogens Mar, 2009 | Pubmed ID: 19282981
Limited amounts of dendritic cells migrate into the T-cell area of lymph nodes but have high immune activating potential in melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2009 | Pubmed ID: 19318472
In situ expression of tumor antigens by messenger RNA-electroporated dendritic cells in lymph nodes of melanoma patients.
Cancer research Apr, 2009 | Pubmed ID: 19318559
Dynamic re-organization of individual adhesion nanoclusters in living cells by ligand-patterned surfaces.
Small (Weinheim an der Bergstrasse, Germany) Jun, 2009 | Pubmed ID: 19367602
The C-type lectin DC-SIGN internalizes soluble antigens and HIV-1 virions via a clathrin-dependent mechanism.
European journal of immunology Jul, 2009 | Pubmed ID: 19585517
Functional differences between mesenchymal stem cell populations are reflected by their transcriptome.
Stem cells and development Apr, 2010 | Pubmed ID: 19788395
Hotspots of GPI-anchored proteins and integrin nanoclusters function as nucleation sites for cell adhesion.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2009 | Pubmed ID: 19850864
The role of tetraspanins in the pathogenesis of infectious diseases.
Microbes and infection / Institut Pasteur Feb, 2010 | Pubmed ID: 19896556
Mesenchymal stem cells respond to TNF but do not produce TNF.
Journal of leukocyte biology Feb, 2010 | Pubmed ID: 19897767
Cord blood mesenchymal stem cells propel human dendritic cells to an intermediate maturation state and boost interleukin-12 production by mature dendritic cells.
Immunology Dec, 2009 | Pubmed ID: 19930046
Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice.
PloS one , 2009 | Pubmed ID: 20020049
Fungal pattern-recognition receptors and tetraspanins: partners on antigen-presenting cells.
Trends in immunology Mar, 2010 | Pubmed ID: 20036798
TLR4-mediated podosome loss discriminates gram-negative from gram-positive bacteria in their capacity to induce dendritic cell migration and maturation.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2010 | Pubmed ID: 20038642
Dominant processes during human dendritic cell maturation revealed by integration of proteome and transcriptome at the pathway level.
Journal of proteome research Apr, 2010 | Pubmed ID: 20131907
Ovarian cancer creates a suppressive microenvironment to escape immune elimination.
Gynecologic oncology May, 2010 | Pubmed ID: 20144842
Hematopoietic stem cells are coordinated by the molecular cues of the endosteal niche.
Stem cells and development Aug, 2010 | Pubmed ID: 20148648
Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro.
Journal of controlled release : official journal of the Controlled Release Society Jun, 2010 | Pubmed ID: 20156497
Consolidative dendritic cell-based immunotherapy elicits cytotoxicity against malignant mesothelioma.
American journal of respiratory and critical care medicine Jun, 2010 | Pubmed ID: 20167848
Dendritic cell subsets digested: RNA sensing makes the difference!
Immunity Feb, 2010 | Pubmed ID: 20189479
Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy.
Cancer immunology, immunotherapy : CII Oct, 2010 | Pubmed ID: 20204387
Molecular friction as a tool to identify functionalized alkanethiols.
Langmuir : the ACS journal of surfaces and colloids May, 2010 | Pubmed ID: 20225883
Human plasmacytoid dendritic cells phagocytose, process, and present exogenous particulate antigen.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2010 | Pubmed ID: 20304825
The tetraspanin CD37 protects against glomerular IgA deposition and renal pathology.
The American journal of pathology May, 2010 | Pubmed ID: 20348240
Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells.
Blood Jul, 2010 | Pubmed ID: 20424184
(19)F MRI for quantitative in vivo cell tracking.
Trends in biotechnology Jul, 2010 | Pubmed ID: 20427096
Customizable, multi-functional fluorocarbon nanoparticles for quantitative in vivo imaging using 19F MRI and optical imaging.
Biomaterials Sep, 2010 | Pubmed ID: 20566214
Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a phase I/II study in metastatic melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research Oct, 2010 | Pubmed ID: 20736326
The lymphoid chemokine CCL21 triggers LFA-1 adhesive properties on human dendritic cells.
Immunology and cell biology Mar, 2011 | Pubmed ID: 20805842
A novel (19)F agent for detection and quantification of human dendritic cells using magnetic resonance imaging.
International journal of cancer. Journal international du cancer Jul, 2011 | Pubmed ID: 20839261
Wild-type and modified gp100 peptide-pulsed dendritic cell vaccination of advanced melanoma patients can lead to long-term clinical responses independent of the peptide used.
Cancer immunology, immunotherapy : CII Feb, 2011 | Pubmed ID: 21069321
DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells.
Immunome research , 2010 | Pubmed ID: 21092113
Immunogenicity of dendritic cells pulsed with CEA peptide or transfected with CEA mRNA for vaccination of colorectal cancer patients.
Anticancer research Dec, 2010 | Pubmed ID: 21187495
IL-4 and IL-13 alter plasmacytoid dendritic cell responsiveness to CpG DNA and herpes simplex virus-1.
The Journal of investigative dermatology Apr, 2011 | Pubmed ID: 21191414
Prophylactic vaccines mimic synthetic CpG oligonucleotides in their ability to modulate immune responses.
Molecular immunology Mar, 2011 | Pubmed ID: 21257206
Targeted antigen delivery and activation of dendritic cells in vivo: steps towards cost effective vaccines.
Seminars in immunology Feb, 2011 | Pubmed ID: 21269839
Eradicating cancer cells: struggle with a chameleon.
Oncotarget Jan-Feb, 2011 | Pubmed ID: 21378413
Multimodal imaging of nanovaccine carriers targeted to human dendritic cells.
Molecular pharmaceutics Apr, 2011 | Pubmed ID: 21381651
DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells.
European journal of immunology Apr, 2011 | Pubmed ID: 21413003
Cytokine analysis as a tool to understand tumour-host interaction in ovarian cancer.
European journal of cancer (Oxford, England : 1990) Aug, 2011 | Pubmed ID: 21514148
Infection of dendritic cells with herpes simplex virus type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration.
Blood Jul, 2011 | Pubmed ID: 21562043
Antigen localization controls T cell-mediated tumor immunity.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2011 | Pubmed ID: 21705625
The influence of PEG chain length and targeting moiety on antibody-mediated delivery of nanoparticle vaccines to human dendritic cells.
Biomaterials Oct, 2011 | Pubmed ID: 21724247
Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice.
The Journal of clinical investigation Aug, 2011 | Pubmed ID: 21765211
Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research Sep, 2011 | Pubmed ID: 21771874
Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells.
Cancer research Oct, 2011 | Pubmed ID: 21788345
Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation.
Blood Oct, 2011 | Pubmed ID: 21860028
Cytokine profiles in cyst fluids from ovarian tumors reflect immunosuppressive state of the tumor.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Oct, 2011 | Pubmed ID: 21946293
Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity.
Blood Dec, 2011 | Pubmed ID: 21967977
Early identification of antigen-specific immune responses in vivo by [18F]-labeled 3'-fluoro-3'-deoxy-thymidine ([18F]FLT) PET imaging.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2011 | Pubmed ID: 22025695
Interlaboratory round robin on cantilever calibration for AFM force spectroscopy.
Ultramicroscopy Dec, 2011 | Pubmed ID: 22094372
Unraveling the human dendritic cell phagosome proteome by organellar enrichment ranking.
Journal of proteomics Feb, 2012 | Pubmed ID: 22146474
The chemotherapeutic drug oxaliplatin differentially affects blood DC function dependent on environmental cues.
Cancer immunology, immunotherapy : CII Jul, 2012 | Pubmed ID: 22193989
Geometry sensing by dendritic cells dictates spatial organization and PGE(2)-induced dissolution of podosomes.
Cellular and molecular life sciences : CMLS Jun, 2012 | Pubmed ID: 22204022
Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?
The lancet oncology Jan, 2012 | Pubmed ID: 22225723
The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells.
Blood Mar, 2012 | Pubmed ID: 22234694
Harnessing human plasmacytoid dendritic cells as professional APCs.
Cancer immunology, immunotherapy : CII Aug, 2012 | Pubmed ID: 22294456
Comparison of antibodies and carbohydrates to target vaccines to human dendritic cells via DC-SIGN.
Biomaterials Jun, 2012 | Pubmed ID: 22410170
Lateral mobility of individual integrin nanoclusters orchestrates the onset for leukocyte adhesion.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2012 | Pubmed ID: 22411821
Targeting nanoparticles to dendritic cells for immunotherapy.
Methods in enzymology , 2012 | Pubmed ID: 22568905
Antibodies and carbohydrate ligands binding to DC-SIGN differentially modulate receptor trafficking.
European journal of immunology Aug, 2012 | Pubmed ID: 22653683
The modular nature of dendritic cell responses to commensal and pathogenic fungi.
PloS one , 2012 | Pubmed ID: 22879980
Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4+ and CD8+ T cells responses in stage III and IV melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research Oct, 2012 | Pubmed ID: 22896657
Insight into the dynamics, localization and magnitude of antigen-specific immune responses by [(18)F]FLT PET imaging.
Oncoimmunology Aug, 2012 | Pubmed ID: 22934268
Labeling cells for in vivo tracking using (19)F MRI.
Biomaterials Dec, 2012 | Pubmed ID: 22959182
Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities.
Blood Nov, 2012 | Pubmed ID: 22966165
Skin-test infiltrating lymphocytes early predict clinical outcome of dendritic cell-based vaccination in metastatic melanoma.
Cancer research Dec, 2012 | Pubmed ID: 23010076
The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells.
The Journal of biological chemistry Nov, 2012 | Pubmed ID: 23019323
ALCAM/CD166 adhesive function is regulated by the tetraspanin CD9.
Cellular and molecular life sciences : CMLS Feb, 2013 | Pubmed ID: 23052204
In vivo imaging of therapy-induced anti-cancer immune responses in humans.
Cellular and molecular life sciences : CMLS Oct, 2012 | Pubmed ID: 23052208
Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination.
Cancer research Jan, 2013 | Pubmed ID: 23087058
In vivo tracking techniques for cellular regeneration, replacement, and redirection.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Dec, 2012 | Pubmed ID: 23143090
Enhancing immunogenicity and cross-reactivity of HIV-1 antigens by in vivo targeting to dendritic cells.
Nanomedicine (London, England) Oct, 2012 | Pubmed ID: 23148541
The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival.
Science signaling Nov, 2012 | Pubmed ID: 23150881
Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsets.
Blood Jan, 2013 | Pubmed ID: 23212525
Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients.
Cancer research Feb, 2013 | Pubmed ID: 23345163
Automated podosome identification and characterization in fluorescence microscopy images.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada Feb, 2013 | Pubmed ID: 23347434
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Clinical cancer research : an official journal of the American Association for Cancer Research Mar, 2013 | Pubmed ID: 23382117
Targeting dendritic cells--why bother?
Blood Apr, 2013 | Pubmed ID: 23390195
The nature of activatory and tolerogenic dendritic cell-derived signal II.
Frontiers in immunology , 2013 | Pubmed ID: 23450201
Dendritic cell-based nanovaccines for cancer immunotherapy.
Current opinion in immunology Jun, 2013 | Pubmed ID: 23571027
Functional OCT4-specific CD4(+) and CD8(+) T cells in healthy controls and ovarian cancer patients.
Oncoimmunology May, 2013 | Pubmed ID: 23762805
Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force.
The Journal of cell biology Jun, 2013 | Pubmed ID: 23798731
Naturally circulating dendritic cells to vaccinate cancer patients.
Oncoimmunology Mar, 2013 | Pubmed ID: 23802086
Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy.
Oncoimmunology Jun, 2013 | Pubmed ID: 23894702
The stem cell markers Oct4A, Nanog and c-Myc are expressed in ascites cells and tumor tissue of ovarian cancer patients.
Cellular oncology (Dordrecht) Oct, 2013 | Pubmed ID: 23928726
Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination.
Oncoimmunology Jul, 2013 | Pubmed ID: 24073362
Targeting uptake receptors on human plasmacytoid dendritic cells triggers antigen cross-presentation and robust type I IFN secretion.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2013 | Pubmed ID: 24127556
Aiming to immune elimination of ovarian cancer stem cells.
World journal of stem cells Oct, 2013 | Pubmed ID: 24179603
Probing cellular heterogeneity in cytokine-secreting immune cells using droplet-based microfluidics.
Lab on a chip Nov, 2013 | Pubmed ID: 24185478
Tumoricidal activity of human dendritic cells.
Trends in immunology Nov, 2013 | Pubmed ID: 24262387
Ipilimumab administered to metastatic melanoma patients who progressed after dendritic cell vaccination.
Oncoimmunology Aug, 2016 | Pubmed ID: 27622070
Restoring immunosurveillance by dendritic cell vaccines and manipulation of the tumor microenvironment.
Immunobiology Feb, 2015 | Pubmed ID: 25466585
Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization.
Journal of the American Chemical Society Apr, 2015 | Pubmed ID: 25785540
Intranodal vaccination with mRNA-optimized dendritic cells in metastatic melanoma patients.
Oncoimmunology Aug, 2015 | Pubmed ID: 26405571
Semaphorin 7A Promotes Chemokine-Driven Dendritic Cell Migration.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2016 | Pubmed ID: 26597008
Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells.
Clinical cancer research : an official journal of the American Association for Cancer Research May, 2016 | Pubmed ID: 26712687
Tetraspanin CD37 protects against the development of B cell lymphoma.
The Journal of clinical investigation Feb, 2016 | Pubmed ID: 26784544
Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity.
Cancer immunology, immunotherapy : CII Mar, 2016 | Pubmed ID: 26861670
Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells.
PloS one , 2016 | Pubmed ID: 26889827
Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination.
Oncoimmunology , 2016 | Pubmed ID: 26942068
Long-lasting multifunctional CD8 T cell responses in end-stage melanoma patients can be induced by dendritic cell vaccination.
Oncoimmunology , 2016 | Pubmed ID: 26942087
Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses.
Oncoimmunology , 2016 | Pubmed ID: 26942088
A Comparative Study of the T Cell Stimulatory and Polarizing Capacity of Human Primary Blood Dendritic Cell Subsets.
Mediators of inflammation , 2016 | Pubmed ID: 27057096
Opportunities for immunotherapy in microsatellite instable colorectal cancer.
Cancer immunology, immunotherapy : CII Oct, 2016 | Pubmed ID: 27060000
Preclinical exploration of combining plasmacytoid and myeloid dendritic cell vaccination with BRAF inhibition.
Journal of translational medicine Apr, 2016 | Pubmed ID: 27075584
Dendritic Cell-Based Immunotherapy: State of the Art and Beyond.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2016 | Pubmed ID: 27084743
T-cell Landscape in a Primary Melanoma Predicts the Survival of Patients with Metastatic Disease after Their Treatment with Dendritic Cell Vaccines.
Cancer research Jun, 2016 | Pubmed ID: 27197179
Immune-related Adverse Events of Dendritic Cell Vaccination Correlate With Immunologic and Clinical Outcome in Stage III and IV Melanoma Patients.
Journal of immunotherapy (Hagerstown, Md. : 1997) , 2016 | Pubmed ID: 27227325
Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines.
Cancer research Aug, 2016 | Pubmed ID: 27325645
Adjuvant Dendritic Cell Vaccination in High-Risk Uveal Melanoma.
Ophthalmology Oct, 2016 | Pubmed ID: 27476772
Adjuvant dendritic cell vaccination induces tumor-specific immune responses in the majority of stage III melanoma patients.
Oncoimmunology Jul, 2016 | Pubmed ID: 27622047
Human CD1c(+) DCs are critical cellular mediators of immune responses induced by immunogenic cell death.
Oncoimmunology Aug, 2016 | Pubmed ID: 27622063
Proteomics of Human Dendritic Cell Subsets Reveals Subset-Specific Surface Markers and Differential Inflammasome Function.
Cell reports Sep, 2016 | Pubmed ID: 27626665
Harnessing RNA sequencing for global, unbiased evaluation of two new adjuvants for dendritic-cell immunotherapy.
Oncotarget Mar, 2017 | Pubmed ID: 28186996
N-glycan mediated adhesion strengthening during pathogen-receptor binding revealed by cell-cell force spectroscopy.
Scientific reports Jul, 2017 | Pubmed ID: 28751750
Migrating into the Tumor: a Roadmap for T Cells.
Trends in cancer Nov, 2017 | Pubmed ID: 29120755
Eight-Color Multiplex Immunohistochemistry for Simultaneous Detection of Multiple Immune Checkpoint Molecules within the Tumor Microenvironment.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2018 | Pubmed ID: 29141863
Dendritic cells in cancer immunotherapy.
Nature materials Jun, 2018 | Pubmed ID: 29795222
A comparative assessment of continuous production techniques to generate sub-micron size PLGA particles.
International journal of pharmaceutics Oct, 2018 | Pubmed ID: 30144511
C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37.
Journal of cell science Oct, 2018 | Pubmed ID: 30185523
Biophysical Characterization of CD6-TCR/CD3 Interplay in T Cells.
Frontiers in immunology , 2018 | Pubmed ID: 30356797
Injectable Biomimetic Hydrogels as Tools for Efficient T Cell Expansion and Delivery.
Frontiers in immunology , 2018 | Pubmed ID: 30546367
Attacking Tumors From All Sides: Personalized Multiplex Vaccines to Tackle Intratumor Heterogeneity.
Frontiers in immunology , 2019 | Pubmed ID: 31040852
ICAM3-Fc Outperforms Receptor-Specific Antibodies Targeted Nanoparticles to Dendritic Cells for Cross-Presentation.
Molecules (Basel, Switzerland) May, 2019 | Pubmed ID: 31083610
Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells.
Frontiers in immunology , 2019 | Pubmed ID: 31130945
Synthetic Semiflexible and Bioactive Brushes.
Biomacromolecules Jul, 2019 | Pubmed ID: 31150222
Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering.
Science advances Aug, 2019 | Pubmed ID: 31489367
Imaging of T-cells and their responses during anti-cancer immunotherapy.
Theranostics Oct, 2019 | Pubmed ID: 31656546
Microfluidics-Assisted Size Tuning and Biological Evaluation of PLGA Particles.
Pharmaceutics Nov, 2019 | Pubmed ID: 31717354
Blood-derived dendritic cell vaccinations induce immune responses that correlate with clinical outcome in patients with chemo-naive castration-resistant prostate cancer.
Journal for immunotherapy of cancer Nov, 2019 | Pubmed ID: 31727154
Intracellular Galectin-9 Controls Dendritic Cell Function by Maintaining Plasma Membrane Rigidity.
iScience Dec, 2019 | Pubmed ID: 31786520
Cross-talk between iNKT cells and CD8 T cells in the spleen requires the IL-4/CCL17 axis for the generation of short-lived effector cells.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2019 | Pubmed ID: 31796596
Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial.
Cancer immunology, immunotherapy : CII Mar, 2020 | Pubmed ID: 31980913
Multicore Liquid Perfluorocarbon-Loaded Multimodal Nanoparticles for Stable Ultrasound and F MRI Applied to In Vivo Cell Tracking.
Advanced functional materials May, 2019 | Pubmed ID: 32132881
The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture.
Nature communications Jun, 2020 | Pubmed ID: 32488012
Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels.
The Journal of cell biology Oct, 2020 | Pubmed ID: 32777015
High Health-Related Quality of Life During Dendritic Cell Vaccination Therapy in Patients With Castration-Resistant Prostate Cancer.
Frontiers in oncology , 2020 | Pubmed ID: 33194595
Nanovaccine administration route is critical to obtain pertinent iNKt cell help for robust anti-tumor T and B cell responses.
Oncoimmunology Mar, 2020 | Pubmed ID: 33457086
Dual Site-Specific Chemoenzymatic Antibody Fragment Conjugation Using CRISPR-Based Hybridoma Engineering.
Bioconjugate chemistry Feb, 2021 | Pubmed ID: 33476135
Human type 1 and type 2 conventional dendritic cells express indoleamine 2,3-dioxygenase 1 with functional effects on T cell priming.
European journal of immunology Jun, 2021 | Pubmed ID: 33675038
PLGA Nanoparticles Co-encapsulating NY-ESO-1 Peptides and IMM60 Induce Robust CD8 and CD4 T Cell and B Cell Responses.
Frontiers in immunology , 2021 | Pubmed ID: 33717196
Semiflexible Immunobrushes Induce Enhanced T Cell Activation and Expansion.
ACS applied materials & interfaces Apr, 2021 | Pubmed ID: 33797875
Three distinct tolerogenic CD14 myeloid cell types to actively manage autoimmune disease: Opportunities and challenges.
Journal of autoimmunity Jun, 2021 | Pubmed ID: 33901801
A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery.
Journal for immunotherapy of cancer May, 2021 | Pubmed ID: 34059522
PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up.
International journal of pharmaceutics Aug, 2021 | Pubmed ID: 34144133
Characterization of Intrinsically Radiolabeled Poly(lactic--glycolic acid) Nanoparticles for ex Vivo Autologous Cell Labeling and in Vivo Tracking.
Bioconjugate chemistry Aug, 2021 | Pubmed ID: 34161070
Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery.
Cancer immunology research Aug, 2021 | Pubmed ID: 34226201
Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity.
Nature communications Sep, 2021 | Pubmed ID: 34471116
In Vivo PET Imaging of Monocytes Labeled with [Zr]Zr-PLGA-NH Nanoparticles in Tumor and Infection Models.
Cancers Oct, 2021 | Pubmed ID: 34680219
Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots.
ACS biomaterials science & engineering Dec, 2021 | Pubmed ID: 34734689
Assessing the safety, tolerability and efficacy of PLGA-based immunomodulatory nanoparticles in patients with advanced NY-ESO-1-positive cancers: a first-in-human phase I open-label dose-escalation study protocol.
BMJ open Nov, 2021 | Pubmed ID: 34848513
Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents.
Journal of nanobiotechnology Feb, 2022 | Pubmed ID: 35109860
Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion.
Journal for immunotherapy of cancer Apr, 2022 | Pubmed ID: 35428705
Design of triphasic poly(lactic--glycolic acid) nanoparticles containing a perfluorocarbon phase for biomedical applications.
RSC advances Feb, 2018 | Pubmed ID: 35540375
Paired primary and metastatic lesions of patients with ipilimumab-treated melanoma: high variation in lymphocyte infiltration and HLA-ABC expression whereas tumor mutational load is similar and correlates with clinical outcome.
Journal for immunotherapy of cancer May, 2022 | Pubmed ID: 35550553
Correction to: Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents Iris.
Journal of nanobiotechnology May, 2022 | Pubmed ID: 35568872
Regulatory T Cell Depletion Using a CRISPR Fc-Optimized CD25 Antibody.
International journal of molecular sciences Aug, 2022 | Pubmed ID: 35955841
Tumor microenvironment shows an immunological abscopal effect in patients with NSCLC treated with pembrolizumab-radiotherapy combination.
Journal for immunotherapy of cancer Oct, 2022 | Pubmed ID: 36252995
Mark A. J. Gorris1,2,
Evgenia Martynova*,1,3,
Mark W. D. Sweep*,1,4,
Iris A. E. van der Hoorn1,5,
Shabaz Sultan1,3,
Mike J. D. E. Claassens1,
Lieke L. van der Woude1,2,6,
Kiek Verrijp1,2,6,
Carl G. Figdor1,3,
Johannes Textor1,3,
I. Jolanda M. de Vries1
1Department of Medical BioSciences, Radboudumc,
2Division of Immunotherapy, Oncode Institute, Radboudumc,
3Data Science, Institute for Computing and Information Sciences, Radboud University,
4Department of Medical Oncology, Radboudumc,
5Department of Pulmonary Diseases, Radboudumc,
6Department of Pathology, Radboudumc
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved