Charles O. Rock

Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis.

A conserved histidine is essential for glycerolipid acyltransferase catalysis.

A missense mutation accounts for the defect in the glycerol-3-phosphate acyltransferase expressed in the plsB26 mutant.

beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis.

Response of Bacillus subtilis to cerulenin and acquisition of resistance.

The licC gene of Streptococcus pneumoniae encodes a CTP:phosphocholine cytidylyltransferase.

Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae.

Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.

The solution structure of acyl carrier protein from Mycobacterium tuberculosis.

The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli.

Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport.

A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.

Forty years of bacterial fatty acid synthesis.

The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes.

A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae.

The Claisen condensation in biology.

Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).

The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.

Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli.

Crystal structures of the Dab homology domains of mouse disabled 1 and 2.

The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae.

Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction.

Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG.

Fatty acid biosynthesis as a target for novel antibacterials.

Product diversity and regulation of type II fatty acid synthases.

Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase.

The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.

Prediction of mechanisms of action of antibacterial compounds by gene expression profiling.

Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites.

A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.

The reductase steps of the type II fatty acid synthase as antimicrobial targets.

Coenzyme A: back in action.

Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters.

Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration.

Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.

Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa.

Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae.

Structure of RhlG, an essential beta-ketoacyl reductase in the rhamnolipid biosynthetic pathway of Pseudomonas aeruginosa.

Inhibiting bacterial fatty acid synthesis.

Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2.

Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens.

Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine.

Topology and active site of PlsY: the bacterial acylphosphate:glycerol-3-phosphate acyltransferase.

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.

Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I.

Identification of a soluble diacylglycerol kinase required for lipoteichoic acid production in Bacillus subtilis.

Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis.

Localization and regulation of mouse pantothenate kinase 2.

A Pseudomonas aeruginosa transcription factor that senses fatty acid structure.

Membrane lipid homeostasis in bacteria.

RhlA converts beta-hydroxyacyl-acyl carrier protein intermediates in fatty acid synthesis to the beta-hydroxydecanoyl-beta-hydroxydecanoate component of rhamnolipids in Pseudomonas aeruginosa.

Thematic review series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis.

Analysis of the Staphylococcus aureus DgkB structure reveals a common catalytic mechanism for the soluble diacylglycerol kinases.

PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa.

Transcriptional regulation in bacterial membrane lipid synthesis.

Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria.

Molecular determinants for interfacial binding and conformational change in a soluble diacylglycerol kinase.

Structural modification of acyl carrier protein by butyryl group.

Acyl-Acyl carrier protein regulates transcription of fatty acid biosynthetic genes via the FabT repressor in Streptococcus pneumoniae.

Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis.

Opening a new path to lipoic acid.

Transcriptional regulation of membrane lipid homeostasis in Escherichia coli.

FabH selectivity for anteiso branched-chain fatty acid precursors in low-temperature adaptation in Listeria monocytogenes.

DesT coordinates the expression of anaerobic and aerobic pathways for unsaturated fatty acid biosynthesis in Pseudomonas aeruginosa.

Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state.

Structural basis for the transcriptional regulation of membrane lipid homeostasis.

Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.

A rainbow coalition of lipid transcriptional regulators.

A σW-dependent stress response in Bacillus subtilis that reduces membrane fluidity.

Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors.

Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway.

Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation.

Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria.

Will the initiator of fatty acid synthesis in Pseudomonas aeruginosa please stand up?

Membrane disruption by antimicrobial fatty acids releases low-molecular-weight proteins from Staphylococcus aureus.

Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1.

Phosphatidic acid synthesis in bacteria.

Preface: phospholipids and phospholipid metabolism.

Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252.

Bacterial lipids: metabolism and membrane homeostasis.

Staphylococcus aureus fatty acid auxotrophs do not proliferate in mice.

Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI).

Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus.

The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.

Incorporation of extracellular fatty acids by a fatty acid kinase-dependent pathway in Staphylococcus aureus.

Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening.

Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance.

Type II fatty acid synthesis is essential for the replication of Chlamydia trachomatis.

Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus.

FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.

A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae.

A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.

How bacterial pathogens eat host lipids: implications for the development of fatty acid synthesis therapeutics.

Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis.

Discovery of bacterial fatty acid synthase type II inhibitors using a novel cellular bioluminescent reporter assay.

Chlamydia trachomatis Scavenges Host Fatty Acids for Phospholipid Synthesis via an Acyl-Acyl Carrier Protein Synthetase.

Maternal bile acid transporter deficiency promotes neonatal demise.

Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy.

Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria.

Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family.

Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics.

A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome.

Allosteric Regulation of Mammalian Pantothenate Kinase.

Bacterial fatty acid metabolism in modern antibiotic discovery.

Enoyl-Acyl Carrier Protein Reductase I (FabI) Is Essential for the Intracellular Growth of Listeria monocytogenes.

Pyruvate Oxidase as a Critical Link between Metabolism and Capsule Biosynthesis in Streptococcus pneumoniae.

T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.

Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2.

Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.

Exogenous fatty acid metabolism in bacteria.

A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer.

Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in .

The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Dihydropteroate Synthase.

Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis.

A therapeutic approach to pantothenate kinase associated neurodegeneration.

Acyl-chain selectivity and physiological roles of fatty acid-binding proteins.

Human pantothenate kinase 4 is a pseudo-pantothenate kinase.

Oleate hydratase from protects against palmitoleic acid, the major antimicrobial fatty acid produced by mammalian skin.

Disruption of Glycolysis by Nutritional Immunity Activates a Two-Component System That Coordinates a Metabolic and Antihost Response by Staphylococcus aureus.

A fatty acid binding protein of facilitates the acquisition of host polyunsaturated fatty acids.