Elizabeth L. Siegler

T Cell Engineering,
Division of Hematology

Mayo Clinic

BIOGRAPHY

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PUBLICATIONS

ERK Activation in CAR T Cells Is Amplified by CD28-Mediated Increase in CD3ζ Phosphorylation.

iScience Apr, 2020 | Pubmed ID: 32325413

Neurotoxicity and Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy: Insights Into Mechanisms and Novel Therapies.

Frontiers in immunology , 2020 | Pubmed ID: 32983132

A Concise Review of Neurologic Complications Associated with Chimeric Antigen Receptor T-cell Immunotherapy.

Neurologic clinics 11, 2020 | Pubmed ID: 33040871

Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia.

Molecular therapy : the journal of the American Society of Gene Therapy 04, 2021 | Pubmed ID: 33388419

CART Cell Toxicities: New Insight into Mechanisms and Management.

Clinical hematology international Dec, 2020 | Pubmed ID: 33409484

CRISPR Takes the Front Seat in CART-Cell Development.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy Mar, 2021 | Pubmed ID: 33638865

Resistance to CART cell therapy: lessons learned from the treatment of hematological malignancies.

Leukemia & lymphoma 09, 2021 | Pubmed ID: 33682608

CART cell imaging: Paving the way for success in CART cell therapy.

Molecular therapy oncolytics Mar, 2021 | Pubmed ID: 33816781

Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity.

Cancer immunology research 09, 2021 | Pubmed ID: 34244299

Targeting Cancer-Associated Fibroblasts in the Bone Marrow Prevents Resistance to CART-Cell Therapy in Multiple Myeloma.

Blood Jan, 2022 | Pubmed ID: 35090171

Challenges of CAR T-cell Therapy in CLL: Lessons Learned.

Experimental hematology Feb, 2022 | Pubmed ID: 35150777

INSTITUTIONS

Mayo Clinic

Mayo Clinic, Rochester

JOVE ARTICLES

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [¹⁸F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Reona Sakemura^1,2,

Michelle J. Cox^1,2,

Aditya Bansal³,

Claudia Manriquez Roman^1,2,4,5,

Mehrdad Hefazi^1,2,

Cynthia J. Vernon³,

Dianna L. Glynn³,

Mukesh K. Pandey³,

Timothy R. DeGrado³,

Elizabeth L. Siegler^1,2,

Saad S. Kenderian^1,2,5,6

¹T Cell Engineering, Mayo Clinic,

²Division of Hematology, Mayo Clinic,

³Department of Radiology, Mayo Clinic,

⁴Regenerative Sciences PhD, Mayo Clinic,

⁵Department of Molecular Medicine, Mayo Clinic,

⁶Department of Immunology, Mayo Clinic

Cancer Research

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Claudia Manriquez Roman^1,2,3,4,5,

R. Leo Sakemura^1,2,

Brooke L. Kimball^1,2,

Fang Jin⁶,

Roman H. Khadka⁶,

Mohamad M. Adada^1,2,

Elizabeth L. Siegler^1,2,

Aaron J. Johnson⁶,

Saad S. Kenderian^1,2,6

¹T Cell Engineering Laboratory, Mayo Clinic, Rochester,

²Division of Hematology, Mayo Clinic, Rochester,

³Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester,

⁴Department of Molecular Medicine, Mayo Clinic, Rochester,

⁵Regenerative Sciences PhD Program, Mayo Clinic, Rochester,

⁶Department of Immunology, Mayo Clinic, Rochester

Cancer Research

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Elizabeth L. Siegler

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}T Cell Engineering,Division of Hematology

Mayo Clinic

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

T Cell Engineering,
Division of Hematology

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [¹⁸F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography