Department of Molecular and Comparative Pathobiology
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Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice.
The American journal of pathology Oct, 2001 | Pubmed ID: 11583977
Heat shock protein 90 and ErbB2 in the cardiac response to doxorubicin injury.
Cancer research Feb, 2007 | Pubmed ID: 17308081
Spontaneous lesions in the reproductive tract and mammary gland of female non-human primates.
Birth defects research. Part B, Developmental and reproductive toxicology Apr, 2007 | Pubmed ID: 17342758
Detection of dose response in chronic doxorubicin-mediated cell death with cardiac technetium 99m annexin V single-photon emission computed tomography.
Molecular imaging May-Jun, 2008 | Pubmed ID: 19123983
Gastric wall healing after NOTES procedures: closure with endoscopic clips provides superior histological outcome compared with threaded tags closure.
Gastrointestinal endoscopy Aug, 2010 | Pubmed ID: 20674622
Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2012 | Pubmed ID: 22403061
X-ray-visible microcapsules containing mesenchymal stem cells improve hind limb perfusion in a rabbit model of peripheral arterial disease.
Stem cells (Dayton, Ohio) Jun, 2012 | Pubmed ID: 22438076
Fatal eosinophilic myocarditis develops in the absence of IFN-γ and IL-17A.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2013 | Pubmed ID: 24048893
Geranylgeranylacetone blocks doxorubicin-induced cardiac toxicity and reduces cancer cell growth and invasion through RHO pathway inhibition.
Molecular cancer therapeutics Jul, 2014 | Pubmed ID: 24737026
Fused X-ray and MR imaging guidance of intrapericardial delivery of microencapsulated human mesenchymal stem cells in immunocompetent swine.
Radiology Aug, 2014 | Pubmed ID: 24749713
ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity.
American journal of physiology. Heart and circulatory physiology Oct, 2015 | Pubmed ID: 26254336
Electrocardiographic Characterization of Cardiac Hypertrophy in Mice that Overexpress the ErbB2 Receptor Tyrosine Kinase.
Comparative medicine Aug, 2015 | Pubmed ID: 26310459
Imaging transplanted stem cells in real time using an MRI dual-contrast method.
Scientific reports Sep, 2015 | Pubmed ID: 26330231
Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways.
Cardiovascular research Mar, 2016 | Pubmed ID: 26692570
A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory: with applications for the evaluation of possible stem cell imaging agents and therapies.
Journal of neuro-oncology 06, 2016 | Pubmed ID: 27021492
Echocardiographic Characterization of a Murine Model of Hypertrophic Obstructive Cardiomyopathy Induced by Cardiac-specific Overexpression of Epidermal Growth Factor Receptor 2.
Comparative medicine , 2016 | Pubmed ID: 27538857
Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 11, 2019 | Pubmed ID: 31795835
Prenatal stress enhances NNK-induced lung tumors in A/J mice.
Carcinogenesis Apr, 2020 | Pubmed ID: 32249286
Development of 5D3-DM1: A Novel Anti-Prostate-Specific Membrane Antigen Antibody-Drug Conjugate for PSMA-Positive Prostate Cancer Therapy.
Molecular pharmaceutics 09, 2020 | Pubmed ID: 32803984
Aging impairs the beneficial effect of granulocyte colony-stimulating factor and stem cell factor on post-myocardial infarction remodeling.
Circulation research Sep, 2006 | Pubmed ID: 16873716
Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2000 | Pubmed ID: 11050120
Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1.
Cancer research Oct, 2003 | Pubmed ID: 14583452
TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome.
The Journal of clinical investigation Dec, 2004 | Pubmed ID: 15546004
A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.
Journal of the American Society of Nephrology : JASN Dec, 2004 | Pubmed ID: 15579506
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Science (New York, N.Y.) Apr, 2006 | Pubmed ID: 16601194
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.
Cancer research Mar, 2007 | Pubmed ID: 17332349
Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation.
The American journal of pathology May, 2008 | Pubmed ID: 18403598
Etanercept, a TNF-alpha binding agent, is ineffective in the prevention of post-ERCP pancreatitis in canines.
JOP : Journal of the pancreas , 2008 | Pubmed ID: 18648137
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.
Molecular cancer therapeutics Sep, 2008 | Pubmed ID: 18790753
Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway.
Cardiovascular research Feb, 2009 | Pubmed ID: 19029137
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
The Journal of clinical investigation Feb, 2009 | Pubmed ID: 19127022
Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor.
Journal of molecular and cellular cardiology Nov, 2009 | Pubmed ID: 19766235
Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice.
Journal of molecular and cellular cardiology Jul, 2010 | Pubmed ID: 20153750
Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy.
Circulation research May, 2010 | Pubmed ID: 20378858
Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.
Journal of the American College of Cardiology Dec, 2010 | Pubmed ID: 20970280
The innate immune response to coxsackievirus B3 predicts progression to cardiovascular disease and heart failure in male mice.
Biology of sex differences Feb, 2011 | Pubmed ID: 21338512
Th2 regulation of viral myocarditis in mice: different roles for TLR3 versus TRIF in progression to chronic disease.
Clinical & developmental immunology , 2012 | Pubmed ID: 22013485
Acute renal venous obstruction is more detrimental to the kidney than arterial occlusion: implication for murine models of acute kidney injury.
American journal of physiology. Renal physiology Mar, 2012 | Pubmed ID: 22114209
Dose-dependent depth of tissue injury with carbon dioxide cryotherapy in porcine GI tract.
Gastrointestinal endoscopy May, 2012 | Pubmed ID: 22301345
Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase.
Journal of the American College of Cardiology May, 2012 | Pubmed ID: 22624839
A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy.
Oncotarget Jun, 2012 | Pubmed ID: 22791660
Beneficial cardiac effects of caloric restriction are lost with age in a murine model of obesity.
Journal of cardiovascular translational research Jun, 2013 | Pubmed ID: 23456569
Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation.
Journal of molecular and cellular cardiology Sep, 2013 | Pubmed ID: 23643588
Endocardial endothelium is a key determinant of force-frequency relationship in rat ventricular myocardium.
Journal of applied physiology (Bethesda, Md. : 1985) Aug, 2013 | Pubmed ID: 23703113
A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease.
Journal of the American Society of Nephrology : JASN Jan, 2014 | Pubmed ID: 24071006
Generation of a cre recombinase-conditional Nos1ap over-expression transgenic mouse.
Biotechnology letters Jun, 2014 | Pubmed ID: 24563304
A novel viscous dissecting gel for endoscopic submucosal dissection: a prospective survival study in a porcine model.
Endoscopy Jul, 2014 | Pubmed ID: 24770967
Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.
The EMBO journal Dec, 2014 | Pubmed ID: 25349190
Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.
EMBO molecular medicine May, 2015 | Pubmed ID: 25820276
An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor.
Chembiochem : a European journal of chemical biology Oct, 2016 | Pubmed ID: 27432157
RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3.
Cancer research Nov, 2016 | Pubmed ID: 27634756
Stationary phase persister/biofilm microcolony of Borrelia burgdorferi causes more severe disease in a mouse model of Lyme arthritis: implications for understanding persistence, Post-treatment Lyme Disease Syndrome (PTLDS), and treatment failure.
Discovery medicine Mar, 2019 | Pubmed ID: 30946803
Noninvasive Monitoring of Allogeneic Stem Cell Delivery with Dual-Modality Imaging-Visible Microcapsules in a Rabbit Model of Peripheral Arterial Disease.
Stem cells international , 2019 | Pubmed ID: 31001343
Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy.
Cardiovascular research May, 2020 | Pubmed ID: 31424496
Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours.
Nanoscale Nov, 2019 | Pubmed ID: 31612183
Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon honokiol treatment.
Cell death discovery , | Pubmed ID: 32963809
A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes.
Cancer discovery May, 2021 | Pubmed ID: 33408241
FATAL RANAVIRUS INFECTION IN A GROUP OF ZOO-HOUSED MELLER'S CHAMELEONS ().
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians Sep, 2019 | Pubmed ID: 33517641
An Improved At-Labeled Agent for PSMA-Targeted α-Therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Feb, 2022 | Pubmed ID: 34088772
GPCR-ErbB transactivation pathways and clinical implications.
Cellular signalling Oct, 2021 | Pubmed ID: 34303814
CRYβB2 enhances tumorigenesis through upregulation of nucleolin in triple negative breast cancer.
Oncogene Sep, 2021 | Pubmed ID: 34341513
Hepatic Steatosis in the Mouse Model of Wilson Disease Coincides with a Muted Inflammatory Response.
The American journal of pathology Jan, 2022 | Pubmed ID: 34627751
Dual-Modality PET-SPECT Image-Guided Pretargeting Delivery in HER2(+) Breast Cancer Models.
Biomacromolecules Nov, 2021 | Pubmed ID: 34704434
Bionized Nanoferrite Particles Alter the Course of Experimental Cryptococcus neoformans Pneumonia.
Antimicrobial agents and chemotherapy Apr, 2022 | Pubmed ID: 35293784
Prenatal stress enhances atherosclerosis and telomere shortening in ApoE knockout mouse offspring.
American journal of physiology. Regulatory, integrative and comparative physiology Jul, 2022 | Pubmed ID: 35411811
The Common Marmoset-Biomedical Research Animal Model Applications and Common Spontaneous Diseases.
Toxicologic pathology Jul, 2022 | Pubmed ID: 35535728
Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer-a preclinical study.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2022 | Pubmed ID: 35675429
Polymeric nanoparticles for dual-targeted theranostic gene delivery to hepatocellular carcinoma.
Science advances Jul, 2022 | Pubmed ID: 35857843
Canine Idiopathic Arteriopathy, Appendicular Bone Infarcts, and Neoplastic Transformation of Bone Infarcts in 108 Dogs ().
Comparative medicine Oct, 2022 | Pubmed ID: 36113969
HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells.
Cancer research Oct, 2022 | Pubmed ID: 36166646
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Communications biology Nov, 2022 | Pubmed ID: 36380187
Comparison of Cardiovascular Pathology in Animal Models of SARS-CoV-2 Infection: Recommendations Regarding Standardization of Research Methods.
Comparative medicine Feb, 2023 | Pubmed ID: 36731878
Shun Ishiyama1,2,3,4,
Casey Kissel5,
Xin Guo1,
Alexis Howard6,
Harumi Saeki7,
Tomoaki Ito8,
Polina Sysa-Shah9,
Hajime Orita10,
Kazuhiro Sakamoto4,
Kathleen Gabrielson1,2
1Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine,
2Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University,
3Department of Surgery, Johns Hopkins University School of Medicine,
4Department of Coloproctological Surgery, Juntendo University Faculty of Medicine,
5Program for Comparative Medicine, Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania,
6, Tuskegee College of Veterinary Medicine,
7Department of Human Pathology, Juntendo University Faculty of Medicine,
8Department of Surgery, Juntendo University Shizuoka Hospital, Juntendo University School of Medicine,
9Department of Urology, The Johns Hopkins School of Medicine,
10Department of Gastroenterology and Minimally Invasive Surgery, Juntendo University Faculty of Medicine
Rachel Vistein1,
Briana Winer2,
Stephanie Myers1,3,
Juliane Liberto4,
Shun Ishiyama1,5,6,
Xin Guo1,
Harumi Saeki7,
Tian-Li Wang4,8,
Ie-Ming Shih2,4,8,
Kathleen Gabrielson1,4,8
1Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine,
2Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine,
3, Texas Tech University School of Veterinary Medicine,
4Department of Pathology, Johns Hopkins University School of Medicine,
5Department of Surgery, Johns Hopkins University School of Medicine,
6Department of Coloproctological Surgery, Juntendo University School of Medicine,
7Department of Human Pathology, Juntendo University School of Medicine,
8Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
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