Schahram Akbarian

Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals.

Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.

Diseases of the mind and brain: Rett's syndrome.

Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.

Diseases of the mind and brain: Rett's syndrome, part II.

Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain.

The neurobiology of Rett syndrome.

Clinical experts on Rett disorder.

Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling.

Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain.

Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia.

Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.

Chromatin immunoprecipitation in postmortem brain.

NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis.

Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders.

Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse.

The molecular pathology of Rett syndrome: synopsis and update.

GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia.

DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons.

Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters.

Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors.

DNA methylation changes in schizophrenia and bipolar disorder.

Isolation of neuronal chromatin from brain tissue.

A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex.

Epigenetic regulation in human brain-focus on histone lysine methylation.

Approaching the molecular pathology of suicide.

Epigenetics in the nervous system.

Restoring GABAergic signaling and neuronal synchrony in schizophrenia.

Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia.

Cingulate white matter neurons in schizophrenia and bipolar disorder.

Cocaine-induced metabolic activation in cortico-limbic circuitry is increased after exposure to the histone deacetylase inhibitor, sodium butyrate.

The molecular pathology of schizophrenia--focus on histone and DNA modifications.

rAAV9--a human-derived adeno-associated virus vector for efficient transgene expression in mouse cingulate cortex.

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex.

A simple method for improving the specificity of anti-methyl histone antibodies.

Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B.

Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.

RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder.

White matter neuron alterations in schizophrenia and related disorders.

Gender-Specific Reduction of Estrogen-Sensitive Small RNA, miR-30b, in Subjects With Schizophrenia.

Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice.

Keep the 'phospho' on MAPK, be happy.

The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism.

Epigenetics of schizophrenia.

Balancing histone methylation activities in psychiatric disorders.

Advancing drug discovery for schizophrenia.

Epigenetic Signatures of Autism: Trimethylated H3K4 Landscapes in Prefrontal Neurons.

Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease.

The neuroepigenetics of suicide.

Chromatin-bound RNA and the neurobiology of psychiatric disease.

Conserved Chromosome 2q31 Conformations Are Associated with Transcriptional Regulation of GAD1 GABA Synthesis Enzyme and Altered in Prefrontal Cortex of Subjects with Schizophrenia.

The Genome in Three Dimensions: A New Frontier in Human Brain Research.

Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice.

Regulation of histone H3K4 methylation in brain development and disease.

Analytical tools and current challenges in the modern era of neuroepigenomics.

Epigenetic mechanisms in schizophrenia.

The future of neuroepigenetics in the human brain.

A role for noncoding variation in schizophrenia.

Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia.

Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition.

Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.

Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia.

Cognition and mood-related behaviors in L3mbtl1 null mutant mice.

miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement.

Quantifying polymorphism and divergence from epigenetic data: a framework for inferring the action of selection.

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity.

Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse.

DNA methylation levels of α-synuclein intron 1 in the aging brain.

Epigenetic Basis of Mental Illness.

Pharmacological modulation of astrocytes and the role of cell type-specific histone modifications for the treatment of mood disorders.

CHRNA7 and CHRFAM7A: psychosis and smoking? Blame the neighbors!

The PsychENCODE project.

Prefrontal Cortex and Social Cognition in Mouse and Man.

RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.

Back to the past in schizophrenia genomics.

NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure.

Understanding the genetic liability to schizophrenia through the neuroepigenome.

Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue.

DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition.

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Insulin-like Growth Factor 1 for Healthy Spines and Healthy Minds?

Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety.

Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex.

Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism.

Spatial genome organization and cognition.

MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice.

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.

Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.

Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2.

The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.

The epigenomics of schizophrenia, in the mouse.

Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes.

Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects.

Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes.

Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells.

Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS.

Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1.

Chromosomal Conformations and Epigenomic Regulation in Schizophrenia.

Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome.

Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia.

Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders.

Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk.

Comprehensive functional genomic resource and integrative model for the human brain.

Epigenetic-genetic chromatin footprinting identifies novel and subject-specific genes active in prefrontal cortex neurons.

Spatial genome exploration in the context of cognitive and neurological disease.

Metabolome signature of autism in the human prefrontal cortex.

CRISPR-based functional evaluation of schizophrenia risk variants.

In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene.

CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder.

Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia.

Special volume: The genomics and epigenomics of schizophrenia.

Use of the epigenetic toolbox
to contextualize common variants associated with schizophrenia risk
.

A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons.

Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior.

A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.

Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells.

Epigenetic Clocks in Schizophrenia: Promising Biomarkers, Foggy Clockwork.

Genotype-phenotype correlation at codon 1740 of SETD2.

A prefrontal-paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice.

Common genetic variation in humans impacts susceptibility to SARS-CoV-2 infection.

Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome.

Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection.

Comprehensive identification of somatic nucleotide variants in human brain tissue.