Simon A. Walker

Analyzing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular Ca2+ homeostasis.

Control of Ras cycling by Ca2+.

Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations.

Visualizing Ras signalling in real-time.

P-Rex2, a new guanine-nucleotide exchange factor for Rac.

GFP fusion proteins to study signaling in live cells.

The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade.

CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.

The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus.

GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins.

P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum.

Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies.

Comparison of the T-tubule system in adult rat ventricular and atrial myocytes, and its role in excitation-contraction coupling and inotropic stimulation.

Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.

The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein.

Characteristics and requirements of basal autophagy in HEK 293 cells.