Uma Lakshmipathy
Life Sciences Solutions,
Cell Biology,
Cell Biology, Life Sciences Solutions
Thermo Fisher Scientific
Uma Lakshmipathy, is the Director of R&D in Cell Biology at Thermo Fisher Scientific. She received her doctoral degree in Molecular Biophysics from the Center for Cellular and Molecular Biology in India and postdoctoral experience in DNA double strand break repair from University of Minnesota Medical School. As a junior faculty at the Stem Cell Institute, University of Minnesota, her work involved developing ex vivo gene repair systems that enable correction of single gene mutations in adult stem cells. Her current work is focused on the development of novel products and services related to stem cells. Her work has resulted in the development of novel cell engineering platform, robust somatic reprogramming systems and comprehensive characterization tools. She is currently involved in clinical-grade pluripotent stem cell generation and cell therapy characterization platforms.
Efficient transfection of embryonic and adult stem cells.
Stem cells (Dayton, Ohio) , 2004 | Pubmed ID: 15277699
Stem cell plasticity.
Blood reviews Jan, 2005 | Pubmed ID: 15572215
Expression of bacterial endonucleases in Saccharomyces cerevisiae mitochondria.
Mitochondrion Nov, 2002 | Pubmed ID: 16120308
Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research.
Stem cells (Dayton, Ohio) Feb, 2007 | Pubmed ID: 17284651
Creation of engineered human embryonic stem cell lines using phiC31 integrase.
Stem cells (Dayton, Ohio) Jan, 2008 | Pubmed ID: 17962703
Concise review: MicroRNA expression in multipotent mesenchymal stromal cells.
Stem cells (Dayton, Ohio) Feb, 2008 | Pubmed ID: 17991914
MicroRNA expression pattern of undifferentiated and differentiated human embryonic stem cells.
Stem cells and development Dec, 2007 | Pubmed ID: 18004940
PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages.
Blood Jul, 2008 | Pubmed ID: 18332228
Micro RNA profiling: an easy and rapid method to screen and characterize stem cell populations.
Methods in molecular biology (Clifton, N.J.) , 2007 | Pubmed ID: 18453251
Gene transfer via nucleofection into adult and embryonic stem cells.
Methods in molecular biology (Clifton, N.J.) , 2007 | Pubmed ID: 18453252
Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis.
Experimental hematology Oct, 2008 | Pubmed ID: 18657893
A single EBV-based vector for stable episomal maintenance and expression of GFP in human embryonic stem cells.
Regenerative medicine Mar, 2009 | Pubmed ID: 19317643
Generation of platform human embryonic stem cell lines that allow efficient targeting at a predetermined genomic location.
Stem cells and development Dec, 2009 | Pubmed ID: 19355838
A simplified culture and polymerase chain reaction identification assay for quality control performance testing of stem cell media products.
Cytotherapy , 2009 | Pubmed ID: 19878062
hESC engineering by integrase-mediated chromosomal targeting.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 19907981
Global Characterization and Genomic Stability of Human MultiStem, A Multipotent Adult Progenitor Cell.
Journal of stem cells , 2009 | Pubmed ID: 20498688
A novel serum-free medium for the expansion of human mesenchymal stem cells.
Stem cell research & therapy , 2010 | Pubmed ID: 20504289
miRNA in pluripotent stem cells.
Regenerative medicine Jul, 2010 | Pubmed ID: 20632858
BacMam-mediated gene delivery into multipotent mesenchymal stromal cells.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21431539
Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus.
Stem cells and development Jan, 2012 | Pubmed ID: 21699412
Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells.
Stem cells international , 2011 | Pubmed ID: 21977042
Novel live alkaline phosphatase substrate for identification of pluripotent stem cells.
Stem cell reviews Sep, 2012 | Pubmed ID: 22426885
Development and characterization of a clinically compliant xeno-free culture medium in good manufacturing practice for human multipotent mesenchymal stem cells.
Stem cells translational medicine Oct, 2012 | Pubmed ID: 23197667
Stable transfection using episomal vectors to create modified human embryonic stem cells.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23546763
Advances in genetic modification of pluripotent stem cells.
Biotechnology advances Nov, 2013 | Pubmed ID: 23856320
CD44 is a negative cell surface marker for pluripotent stem cell identification during human fibroblast reprogramming.
PloS one , 2014 | Pubmed ID: 24416407
Characterizing Pluripotent Stem Cells Using the TaqMan® hPSC Scorecard(TM) Panel.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 25138722
Current methods and challenges in the comprehensive characterization of human pluripotent stem cells.
Stem cell reviews Apr, 2015 | Pubmed ID: 25504379
Good Cell Culture Practice for stem cells and stem-cell-derived models.
ALTEX , 2017 | Pubmed ID: 27554434
Generation and comprehensive characterization of induced pluripotent stem cells for translational research.
Regenerative medicine 06, 2019 | Pubmed ID: 31115261
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