Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

1.3K Views

•

05:25 min

•

July 21st, 2023

DOI :

10.3791/65613-v

July 21st, 2023

•

Yuanqi Liu*¹^,²^,³^,⁴^,⁵, Siyuan Sun*¹^,²^,³^,⁴^,⁵, Ziyi Jiang*⁶, Xinyi Gong¹^,²^,³^,⁴^,⁵, Yiling Yang¹^,²^,³^,⁴^,⁵, Yanfei Zhu¹^,²^,³^,⁴^,⁵, Hongyuan Xu¹^,²^,³^,⁴^,⁵, Anting Jin¹^,²^,³^,⁴^,⁵, Xiangru Huang¹^,²^,³^,⁴^,⁵, Xin Gao¹^,²^,³^,⁴^,⁵, Tingwei Lu¹^,²^,³^,⁴^,⁵, Jingyi Liu¹^,²^,³^,⁴^,⁵, Xinyu Wang¹^,²^,³^,⁴^,⁵, Qinggang Dai²^,³^,⁴^,⁵^,⁷, Lingyong Jiang¹^,²^,³^,⁴^,⁵

¹Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, ²College of Stomatology, Shanghai Jiao Tong University, ³National Center for Stomatology, ⁴National Clinical Research Center for Oral Diseases, ⁵Shanghai Key Laboratory of Stomatology, ⁶Shanghai Starriver Bilingual School, ⁷The 2nd Dental Center, Ninth People’s Hospital, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

Summary

This study provides a protocol for using inducible osteoblast lineage-specific Stat3 knockout mice to study bone remodeling under orthodontic force and describes methods for analyzing alveolar bone remodeling during orthodontic tooth movement, thus shedding light on skeletal mechanical biology.

Explore More Videos

Inducible Knockout Mice

Alveolar Bone Remodeling

Orthodontic Tooth Movement

Micro computed Tomography

Histological Analysis

Mechanobiology

Chapters in this video