Nikolaus Plesnila

Measurement of absolute values of hemoglobin oxygenation in the brain of small rodents by near infrared reflection spectrophotometry.

Function of BID -- a molecule of the bcl-2 family -- in ischemic cell death in the brain.

Release of excitatory amino acids in the penumbra of a focal cortical necrosis.

Nitric oxide in the penumbra of a focal cortical necrosis in rats.

Lipid-sugar particles for intracranial drug delivery: safety and biocompatibility.

Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.

Neuroprotection in transient focal cerebral ischemia by combination drug therapy and mild hypothermia: comparison with customary therapeutic regimen.

Relative cerebral blood flow during the secondary expansion of a cortical lesion in rats.

Combination drug therapy and mild hypothermia after transient focal cerebral ischemia in rats.

Effect of decompression craniotomy on increase of contusion volume and functional outcome after controlled cortical impact in mice.

Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol.

Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia.

Leukocyte-endothelium interactions during permanent focal cerebral ischemia in mice.

Identification of brain tissue necrosis by MRI: validation by histomorphometry.

Role of arginine vasopressin V1 and V2 receptors for brain damage after transient focal cerebral ischemia.

Release of bradykinin and expression of kinin B2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice.

Motoneuron survival after C7 nerve root avulsion and replantation in the adult rabbit: effects of local ciliary neurotrophic factor and brain-derived neurotrophic factor application.

Cluster analysis: a useful tool for the analysis of cerebral laser-Doppler scanning data.

Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb.

Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.

Hypertonic fluid resuscitation from subarachnoid hemorrhage in rats: a comparison between small volume resuscitation and mannitol.

Arterial hypotension triggers perifocal depolarizations and aggravates secondary damage in focal brain injury.

Simultaneous bilateral laser Doppler fluxmetry and electrophysiological recording during middle cerebral artery occlusion in rats.

Lactacidosis-induced glial cell swelling depends on extracellular Ca2+.

Influence of the duration of ischemia and reperfusion on infarct volume and microvascular damage in mice.

Therapeutic window of bradykinin B2 receptor inhibition after focal cerebral ischemia in rats.

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice.

Effect of early and delayed decompressive craniectomy on secondary brain damage after controlled cortical impact in mice.

Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.

Non-invasive intraoperative monitoring of blood pressure and arterial pCO2 during surgical anesthesia in mice.

Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons.

Effect of oxidative stress on glial cell volume.

Characterization of microvascular basal lamina damage and blood-brain barrier dysfunction following subarachnoid hemorrhage in rats.

Decompression craniectomy after traumatic brain injury: recent experimental results.

Aldolase C-positive cerebellar Purkinje cells are resistant to delayed death after cerebral trauma and AMPA-mediated excitotoxicity.

Enantio-selective effects of clenbuterol in cultured neurons and astrocytes, and in a mouse model of cerebral ischemia.

Complex level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig.

Role of cortical spreading depressions for secondary brain damage after traumatic brain injury in mice.

Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke.

Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol.

Expression and functional role of potassium-chloride cotransporters (KCC) in astrocytes and C6 glioma cells.

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.

Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury.

Role of vasopressin V(1a) and V2 receptors for the development of secondary brain damage after traumatic brain injury in mice.

Effects of transient focal cerebral ischemia in mice deficient in puma.

Brain edema formation and neurological impairment after subarachnoid hemorrhage in rats. Laboratory investigation.

Anatibant, a selective non-peptide bradykinin B2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury.

Inhibition of bradykinin B2 receptors before, not after onset of experimental subarachnoid hemorrhage prevents brain edema formation and improves functional outcome.

The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice.

Mild hypothermia (33 degrees C) reduces intracranial hypertension and improves functional outcome after subarachnoid hemorrhage in rats.

Level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig depend on the stimulus frequency.

The role of bradykinin B(1) and B(2) receptors for secondary brain damage after traumatic brain injury in mice.

Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice.

Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death.

High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice.

Standardized induction of subarachnoid hemorrhage in mice by intracranial pressure monitoring.

BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor.

Characterization of a 3-vessel occlusion model for the induction of complete global cerebral ischemia in mice.

Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

Contribution of bradykinin receptors to the development of secondary brain damage after experimental subarachnoid hemorrhage.

Fluid resuscitation after traumatic brain injury with hypovolemic shock: still a bloody business?

In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury.

Role of apoptosis inducing factor (AIF) for hippocampal neuronal cell death following global cerebral ischemia in mice.

Contribution of matrix metalloproteinase-9 to cerebral edema and functional outcome following experimental subarachnoid hemorrhage.

Vasopressin V(1a) receptors mediate posthemorrhagic systemic hypertension thereby determining rebleeding rate and outcome after experimental subarachnoid hemorrhage.

Experimental subarachnoid hemorrhage causes early and long-lasting microarterial constriction and microthrombosis: an in-vivo microscopy study.

Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles.

Nitric oxide: considerations for the treatment of ischemic stroke.

Paving the road to translation.

Impact of anesthesia on pathophysiology and mortality following subarachnoid hemorrhage in rats.

Inhalation of NO during myocardial ischemia reduces infarct size and improves cardiac function.

Connexin 36 promotes cortical spreading depolarization and ischemic brain damage.

Inhaled nitric oxide reduces secondary brain damage after traumatic brain injury in mice.

Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction.

Arginine vasopressin V1a receptor-deficient mice have reduced brain edema and secondary brain damage following traumatic brain injury.

In vivo temporal and spatial profile of leukocyte adhesion and migration after experimental traumatic brain injury in mice.

Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected].

Bradykinin in blood and cerebrospinal fluid after acute cerebral lesions: correlations with cerebral edema and intracranial pressure.

Pathophysiological Role of Global Cerebral Ischemia following Subarachnoid Hemorrhage: The Current Experimental Evidence.

A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies.

Inhaled nitric oxide protects males but not females from neonatal mouse hypoxia-ischemia brain injury.

Preclinical phase III trials in translational stroke research: call for collective design of framework and guidelines.

Sustained alterations of hypothalamic tanycytes during posttraumatic hypopituitarism in male mice.

CO2 has no therapeutic effect on early microvasospasm after experimental subarachnoid hemorrhage.

Effect of small molecule vasopressin V1a and V2 receptor antagonists on brain edema formation and secondary brain damage following traumatic brain injury in mice.

Protocol for the induction of subarachnoid hemorrhage in mice by perforation of the Circle of Willis with an endovascular filament.

The neuroprotective effect of 17β-estradiol is independent of its antioxidative properties.

Endothelial nitric oxide synthase mediates arteriolar vasodilatation after traumatic brain injury in mice.

Contributions of the immune system to the pathophysiology of traumatic brain injury - evidence by intravital microscopy.

Identification of the Vascular Source of Vasogenic Brain Edema following Traumatic Brain Injury Using In Vivo 2-Photon Microscopy in Mice.

Effect of decompressive craniectomy on outcome following subarachnoid hemorrhage in mice.

Dysfunction of mouse cerebral arteries during early aging.

Are We Barking Up the Wrong Vessels? Cerebral Microcirculation After Subarachnoid Hemorrhage.

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

Temporal Profile of MicroRNA Expression in Contused Cortex after Traumatic Brain Injury in Mice.

The immune system in traumatic brain injury.

Nitric oxide inhalation reduces brain damage, prevents mortality, and improves neurological outcome after subarachnoid hemorrhage by resolving early pial microvasospasms.

Acute changes in neurovascular reactivity after subarachnoid hemorrhage in vivo.

The Formation of Microthrombi in Parenchymal Microvessels after Traumatic Brain Injury Is Independent of Coagulation Factor XI.

Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines.

Inadequate food and water intake determine mortality following stroke in mice.

Recent progress in translational research on neurovascular and neurodegenerative disorders.

Inversion of neurovascular coupling after subarachnoid hemorrhage in vivo.

Decreased Secondary Lesion Growth and Attenuated Immune Response after Traumatic Brain Injury in Mice.

Cylindromatosis mediates neuronal cell death in vitro and in vivo.

Microvasospasms After Experimental Subarachnoid Hemorrhage Do Not Depend on Endothelin A Receptors.

Capillary flow disturbances after experimental subarachnoid hemorrhage: A contributor to delayed cerebral ischemia?

Plasminogen activator inhibitor-1 augments damage by impairing fibrinolysis after traumatic brain injury.

Vasopressin V Receptors Regulate Cerebral Aquaporin 1 after Traumatic Brain Injury.

Quality of life up to 10 years after traumatic brain injury: a cross-sectional analysis.

Decompressive Craniectomy Is Associated With Good Quality of Life Up to 10 Years After Rehabilitation From Traumatic Brain Injury.

Contusion Rodent Model of Traumatic Brain Injury: Controlled Cortical Impact.

Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span.

Potassium ions promote hexokinase-II dependent glycolysis.

RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury.

Scavenging Free Iron Reduces Arteriolar Microvasospasms After Experimental Subarachnoid Hemorrhage.

Immobilization of Recombinant Fluorescent Biosensors Permits Imaging of Extracellular Ion Signals.

A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium-Mediated Excitotoxicity.

Dynamic tracing using ultra-bright labeling and multi-photon microscopy identifies endothelial uptake of poloxamer 188 coated poly(lactic-co-glycolic acid) nano-carriers in vivo.

Adhesion of Leukocytes to Cerebral Venules Precedes Neuronal Cell Death and Is Sufficient to Trigger Tissue Damage After Cerebral Ischemia.

Perfusion pressure determines vascular integrity and histomorphological quality following perfusion fixation of the brain.

Size-Selective Transfer of Lipid Nanoparticle-Based Drug Carriers Across the Blood Brain Barrier Via Vascular Occlusions Following Traumatic Brain Injury.

Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke.

To see or not to see: In vivo nanocarrier detection methods in the brain and their challenges.

Probing intracellular potassium dynamics in neurons with the genetically encoded sensor lc-LysM GEPII 1.0 in vitro and in vivo.

Combining array tomography with electron tomography provides insights into leakiness of the blood-brain barrier in mouse cortex.