Laboratory of Cochlear Development
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Knock-in mouse model for resistance to thyroid hormone (RTH): an RTH mutation in the thyroid hormone receptor beta gene disrupts cochlear morphogenesis.
Journal of the Association for Research in Otolaryngology : JARO Sep, 2002 | Pubmed ID: 12382103
Fibroblast growth factor signaling regulates pillar cell development in the organ of corti.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2002 | Pubmed ID: 12417662
Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea.
Development (Cambridge, England) Jun, 2003 | Pubmed ID: 12702652
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals.
Nature May, 2003 | Pubmed ID: 12724779
Determination and commitment of mechanosensory hair cells.
TheScientificWorldJournal Apr, 2002 | Pubmed ID: 12805965
Exposing the roots of hair cell regeneration in the ear.
Nature medicine Oct, 2003 | Pubmed ID: 14520370
Planar and vertical signals control cellular differentiation and patterning in the mammalian cochlea.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2003 | Pubmed ID: 14561877
Analysis of nuclear receptor function in the mouse auditory system.
Methods in enzymology , 2003 | Pubmed ID: 14631859
Cell adhesion molecules during inner ear and hair cell development, including notch and its ligands.
Current topics in developmental biology , 2003 | Pubmed ID: 14674486
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2004 | Pubmed ID: 14993610
Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.
Cell Mar, 2004 | Pubmed ID: 15035989
Cellular growth and rearrangement during the development of the mammalian organ of Corti.
Developmental dynamics : an official publication of the American Association of Anatomists Apr, 2004 | Pubmed ID: 15042704
Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene.
Human molecular genetics Sep, 2004 | Pubmed ID: 15254021
From placode to polarization: new tunes in inner ear development.
Development (Cambridge, England) Sep, 2004 | Pubmed ID: 15319325
Math1 regulates development of the sensory epithelium in the mammalian cochlea.
Nature neuroscience Dec, 2004 | Pubmed ID: 15543141
Planar cell polarity and a potential role for a Wnt morphogen gradient in stereociliary bundle orientation in the mammalian inner ear.
Journal of neurobiology Sep, 2005 | Pubmed ID: 16041762
Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2006 | Pubmed ID: 16407553
Hair cell development: commitment through differentiation.
Brain research May, 2006 | Pubmed ID: 16626654
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2006 | Pubmed ID: 16687519
Noncanonical Wnt signaling and neural polarity.
Annual review of neuroscience , 2006 | Pubmed ID: 16776590
Regulation of cell fate in the sensory epithelia of the inner ear.
Nature reviews. Neuroscience Nov, 2006 | Pubmed ID: 17053809
Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes.
Hearing research Feb, 2007 | Pubmed ID: 17204383
Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system.
The European journal of neuroscience Feb, 2007 | Pubmed ID: 17331196
Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment.
Developmental dynamics : an official publication of the American Association of Anatomists Jul, 2007 | Pubmed ID: 17557302
Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea.
Development (Cambridge, England) Aug, 2007 | Pubmed ID: 17634195
Cellular commitment and differentiation in the organ of Corti.
The International journal of developmental biology , 2007 | Pubmed ID: 17891718
Has hair cell loss MET its match?
Proceedings of the National Academy of Sciences of the United States of America Oct, 2007 | Pubmed ID: 17925436
Jxc1/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of corti.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2008 | Pubmed ID: 18579736
Leading Wnt down a PCP path: Cthrc1 acts as a coreceptor in the Wnt-PCP pathway.
Developmental cell Jul, 2008 | Pubmed ID: 18606135
Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2008 | Pubmed ID: 18632939
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2008 | Pubmed ID: 19011097
Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.
Development (Cambridge, England) Jun, 2009 | Pubmed ID: 19439495
Building the world's best hearing aid; regulation of cell fate in the cochlea.
Current opinion in genetics & development Aug, 2009 | Pubmed ID: 19604683
Regulation of cell fate and patterning in the developing mammalian cochlea.
Current opinion in otolaryngology & head and neck surgery Oct, 2009 | Pubmed ID: 19623076
Specification of cell fate in the mammalian cochlea.
Birth defects research. Part C, Embryo today : reviews Sep, 2009 | Pubmed ID: 19750520
Sox2 induces neuronal formation in the developing mammalian cochlea.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2010 | Pubmed ID: 20071536
Transfection of mouse cochlear explants by electroporation.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] Apr, 2010 | Pubmed ID: 20373505
CD44 is a marker for the outer pillar cells in the early postnatal mouse inner ear.
Journal of the Association for Research in Otolaryngology : JARO Sep, 2010 | Pubmed ID: 20386946
Development of tonotopy in the auditory periphery.
Hearing research Jun, 2011 | Pubmed ID: 21276841
Rbpj regulates development of prosensory cells in the mammalian inner ear.
Developmental biology May, 2011 | Pubmed ID: 21420948
Response to a letter to the editor.
Hearing research Oct, 2011 | Pubmed ID: 21600274
Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2011 | Pubmed ID: 21646512
Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2011 | Pubmed ID: 22159122
Examining planar cell polarity in the mammalian cochlea.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22218900
Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway.
Neuron Jan, 2012 | Pubmed ID: 22243746
Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis.
The Journal of clinical investigation Apr, 2012 | Pubmed ID: 22446187
Stem cell therapy for the inner ear: recent advances and future directions.
Trends in amplification Mar, 2012 | Pubmed ID: 22514095
Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea.
Development (Cambridge, England) Jun, 2012 | Pubmed ID: 22573615
Fgf signaling regulates development and transdifferentiation of hair cells and supporting cells in the basilar papilla.
Hearing research Jul, 2012 | Pubmed ID: 22575790
Molecular mechanisms of inner ear development.
Cold Spring Harbor perspectives in biology Aug, 2012 | Pubmed ID: 22855724
Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear.
Development (Cambridge, England) Oct, 2012 | Pubmed ID: 22991442
A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea.
Development (Cambridge, England) Dec, 2012 | Pubmed ID: 23132246
Planar cell polarity in the inner ear.
Current topics in developmental biology , 2012 | Pubmed ID: 23140627
Fibroblast growth factor receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of Corti.
Bioarchitecture Nov-Dec, 2012 | Pubmed ID: 23267415
The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea.
Developmental biology Apr, 2013 | Pubmed ID: 23318633
Cilia, Wnt signaling, and the cytoskeleton.
Cilia , 2012 | Pubmed ID: 23351924
Thyroid hormone increases fibroblast growth factor receptor expression and disrupts cell mechanics in the developing organ of corti.
BMC developmental biology , 2013 | Pubmed ID: 23394545
Making sense with thyroid hormone--the role of T(3) in auditory development.
Nature reviews. Endocrinology May, 2013 | Pubmed ID: 23529044
Making connections in the inner ear: recent insights into the development of spiral ganglion neurons and their connectivity with sensory hair cells.
Seminars in cell & developmental biology May, 2013 | Pubmed ID: 23660234
Expression of insulin-like growth factor binding proteins during mouse cochlear development.
Developmental dynamics : an official publication of the American Association of Anatomists Oct, 2013 | Pubmed ID: 23813480
Expression and function of scleraxis in the developing auditory system.
PloS one , 2013 | Pubmed ID: 24058692
Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.
PLoS biology Nov, 2013 | Pubmed ID: 24302887
A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear.
Nature communications , 2014 | Pubmed ID: 24845721
Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
Nature communications , 2014 | Pubmed ID: 24845860
Pou3f4-mediated regulation of ephrin-b2 controls temporal bone development in the mouse.
PloS one , 2014 | Pubmed ID: 25299585
Kaya J.E. Matson1,
Anupama Sathyamurthy1,
Kory R. Johnson2,
Michael C. Kelly3,4,
Matthew W. Kelley3,
Ariel J. Levine1
1Spinal Circuits and Plasticity Unit, National Institute of Neurological Disorders and Stroke,
2Bioinformatics Section, Information Technology Program, National Institute of Neurological Disorders and Stroke,
3Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders,
4Single Cell Analysis Facility, Frederick National Laboratory
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