Dominique Bonnet

WTX is rarely mutated in acute myeloid leukemia.

Haematopoietic stem cells.

Male cells in female recipients of hematopoietic-cell transplants.

C1qRp defines a new human stem cell population with hematopoietic and hepatic potential.

Solid-phase synthesis of tetrahydro-beta-carbolinehydantoins via the N-acyliminium Pictet-Spengler reaction and cyclative cleavage.

Simultaneous lipidation of a characterized peptide mixture by chemoselective ligation.

Expansion of human SCID-repopulating cells under hypoxic conditions.

Solid-phase functionalization of peptides by an alpha-hydrazinoacetyl group.

Multiparameter analysis of murine bone marrow side population cells.

Hematopoietic stem cells.

In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions.

Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3.

Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples.

Stem cells of the alveolar epithelium.

Normal and leukaemic stem cells.

Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells.

Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.

Effect of glycoamphiphiles on the solubilization and dendritic cell uptake of a lipopeptide: a preliminary study.

AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML.

Telomerase vaccination has no detectable effect on SCID-repopulating and colony-forming activities in the bone marrow of cancer patients.

In vivo formation of unstable heterokaryons after liver damage and hematopoietic stem cell/progenitor transplantation.

Leukemic stem cells show the way.

Implications of the expression of myeloid markers on normal and leukemic stem cells.

Development of a quantitative real-time polymerase chain reaction method for monitoring CEBPA mutations in normal karyotype acute myeloid leukaemia.

Out of the blue: a comparison of Hoechst side population (SP) analysis of murine bone marrow using 325, 363 and 407 nm excitation sources.

Nonhematopoietic/endothelial SSEA-1+ cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment.

Use of a fluorescent polarization based high throughput assay to identify new calmodulin ligands.

A rapid and versatile method to label receptor ligands using "click" chemistry: Validation with the muscarinic M1 antagonist pirenzepine.

Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging.

Convenient method to access new 4,4-dialkoxy- and 4,4-diaryloxy-diaza-s-indacene dyes: Synthesis and spectroscopic evaluation.

Solid-phase preparation of a pilot library derived from the 2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-amine scaffold.

Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung.

Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells.

The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells.

Flexible and dynamic organization of bone marrow stromal compartment.

Ageing within the hematopoietic stem cell compartment.

Solid-phase organic tagging resins for labeling biomolecules by 1,3-dipolar cycloaddition: application to the synthesis of a fluorescent non-peptidic vasopressin receptor ligand.

Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells.

Small neutralizing molecules to inhibit actions of the chemokine CXCL12.

Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party.

Isolation, culture, and differentiation potential of mouse marrow stromal cells.

In vivo evaluation of leukemic stem cells through the xenotransplantation model.

Humanized mouse models to study the human haematopoietic stem cell compartment.

Humanized model to study leukemic stem cells.

AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo.

Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus.

Circulating microparticles and procoagulant activity in elderly patients.

Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis.

Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist.

Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction.

alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells.

Neutralizing endogenous chemokines with small molecules. Principles and potential therapeutic applications.

Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis.

"Microenvironmental contaminations" induced by fluorescent lipophilic dyes used for noninvasive in vitro and in vivo cell tracking.

Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells.

An antagonistic pair of FT homologs mediates the control of flowering time in sugar beet.

Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter.

β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.

Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation.

Prospective identification and isolation of murine bone marrow derived multipotent mesenchymal progenitor cells.

Age-related changes in human hematopoietic stem/progenitor cells.

Involvement of the TGFβ pathway in the regulation of α5 β1 integrins by caveolin-1 in human glioblastoma.

Aerodynamically assisted bio-jetting of hematopoietic stem cells.

Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors.

Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice.

DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues.

Combinatorial aid for underprivileged scaffolds: solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (Aza-DKP).

Human mesenchymal stromal cells senesce with exogenous OCT4.

Engraftment defect of cytokine-cultured adult human mobilized CD34(+) cells is related to reduced adhesion to bone marrow niche elements.

Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms.

CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis.

Selective fluorescent nonpeptidic antagonists for vasopressin V₂ GPCR: application to ligand screening and oligomerization assays.

Cancer stem cell definitions and terminology: the devil is in the details.

Heterogeneity of neoplastic stem cells: theoretical, functional, and clinical implications.

Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor.

An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in mice.

Exploration of the orthosteric/allosteric interface in human M1 muscarinic receptors by bitopic fluorescent ligands.

Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells.

Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation.

CD34(-) cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures.

DNA methylation analysis of murine hematopoietic side population cells during aging.

Active RHOA favors retention of human hematopoietic stem/progenitor cells in their niche.

HIF-2α protects human hematopoietic stem/progenitors and acute myeloid leukemic cells from apoptosis induced by endoplasmic reticulum stress.

A novel model of dormancy for bone metastatic breast cancer cells.

Forgotten gems: human CD34(-) hematopoietic stem cells.

Red fluorescent turn-on ligands for imaging and quantifying G protein-coupled receptors in living cells.

A niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: a new tool to decipher their chemoresistance and self-renewal mechanisms.

Structure-activity relationship studies toward the discovery of selective apelin receptor agonists.

Mesenchymal stem cell biodistribution, migration, and homing in vivo.

Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo.

Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process.

CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?

Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer.

Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging.

Increasing cellular immunogenicity to peptide-based vaccine candidates using a fluorocarbon antigen delivery system.

Selective nonpeptidic fluorescent ligands for oxytocin receptor: design, synthesis, and application to time-resolved FRET binding assay.

APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts.

Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo.

Characteristics of human primary mantle cell lymphoma engraftment in NSG mice.

New fluorescein precursors for live bacteria detection.

[Heroin makes asthma difficult and sometimes nearly fatal].

A strategy to discover decoy chemokine ligands with an anti-inflammatory activity.

Different Motile Behaviors of Human Hematopoietic Stem versus Progenitor Cells at the Osteoblastic Niche.

Natural Killer Cells Improve Hematopoietic Stem Cell Engraftment by Increasing Stem Cell Clonogenicity In Vitro and in a Humanized Mouse Model.

The Wilms Tumor-1 (WT1) rs2234593 variant is a prognostic factor in normal karyotype acute myeloid leukemia.

A 4-gene expression score associated with high levels of Wilms Tumor-1 (WT1) expression is an adverse prognostic factor in acute myeloid leukaemia.

SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment.

Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact.

Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.

Frequency and Dynamics of Leukemia-Initiating Cells during Short-term Ex Vivo Culture Informs Outcomes in Acute Myeloid Leukemia Patients.

Perturbed hematopoiesis in mice lacking ATMIN.

A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis.

T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments.

Myelodysplastic syndrome can propagate from the multipotent progenitor compartment.

Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects.

Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells.

Versatile humanized niche model enables study of normal and malignant human hematopoiesis.

Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines.

A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor.

Acute myeloid leukemia including favorable-risk group samples engraft in NSG mice: just be patient.

Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions.

Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation.

Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors.