Daniel Khananshvili

Direct Loading of the purified endogenous inhibitor into the cytoplasm of patched cardiomyocytes blocks the ion currents and calcium transport through the NCX1 protein.

The endogenous inhibitor of NCX1 does not resemble the properties of digitalis compound.

Inotropic and lusitropic effects induced by the inhibitory factor of the Na/Ca exchanger are not mediated by the beta-adrenergic activation.

The low molecular weight inhibitor of NCX1 interacts with a cytosolic domain that differs from the ion-transport site of the Na/Ca exchanger.

Advanced procedures for separation and analysis of low molecular weight inhibitor (NCXIF) of the cardiac sodium-calcium exchanger.

Purified endogenous inhibitor of the Na/Ca exchanger can enhance the cardiomyocytes contractility and calcium transients.

Single alpha-domain constructs of the Na+/Ca2+ exchanger, NCLX, oligomerize to form a functional exchanger.

Effects of purified endogenous inhibitor of the Na+/Ca2+ exchanger on ouabain-induced arrhythmias in the atria and ventricle strips of guinea pig.

Kinetic and equilibrium properties of regulatory calcium sensors of NCX1 protein.

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.

Essential role of the CBD1-CBD2 linker in slow dissociation of Ca2+ from the regulatory two-domain tandem of NCX1.

Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger.

Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants.

A common Ca2+-driven interdomain module governs eukaryotic NCX regulation.

G503 is obligatory for coupling of regulatory domains in NCX proteins.

The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion.

Molecular determinants of allosteric regulation in NCX proteins.

The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.

NCLX: the mitochondrial sodium calcium exchanger.

SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells.

Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX).

The C2B domain is the primary Ca2+ sensor in DOC2B: a structural and functional analysis.

Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions.

Functional asymmetry of bidirectional Ca2+-movements in an archaeal sodium-calcium exchanger (NCX_Mj).

Structure-dynamic determinants governing a mode of regulatory response and propagation of allosteric signal in splice variants of Na+/Ca2+ exchange (NCX) proteins.

Sodium recognition by the Na+/Ca2+ exchanger in the outward-facing conformation.

Structure-dynamic basis of splicing-dependent regulation in tissue-specific variants of the sodium-calcium exchanger.

Asymmetric Preorganization of Inverted Pair Residues in the Sodium-Calcium Exchanger.

Structural Features of Ion Transport and Allosteric Regulation in Sodium-Calcium Exchanger (NCX) Proteins.

Kinetic and equilibrium properties of regulatory Ca(2+)-binding domains in sodium-calcium exchangers 2 and 3.

Structure-Based Engineering of Lithium-Transport Capacity in an Archaeal Sodium-Calcium Exchanger.

Structure-Functional Basis of Ion Transport in Sodium-Calcium Exchanger (NCX) Proteins.

Purification and characterization of human dehydrodolychil diphosphate synthase (DHDDS) overexpressed in E. coli.

Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms.

Dynamic distinctions in the Na(+)/Ca(2+) exchanger adopting the inward- and outward-facing conformational states.

How a helix imposes palmitoylation of a membrane protein: What one can learn from NCX.