Department of Physiology and Pharmacology,
Sackler Faculty of Medicine,
Department of Physiology and Pharmacology, Sackler Faculty of Medicine
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Direct Loading of the purified endogenous inhibitor into the cytoplasm of patched cardiomyocytes blocks the ion currents and calcium transport through the NCX1 protein.
Biochemistry Jun, 2008 | Pubmed ID: 18507397
The endogenous inhibitor of NCX1 does not resemble the properties of digitalis compound.
Biochemical and biophysical research communications Aug, 2003 | Pubmed ID: 12890488
Inotropic and lusitropic effects induced by the inhibitory factor of the Na/Ca exchanger are not mediated by the beta-adrenergic activation.
Journal of cardiovascular pharmacology Oct, 2004 | Pubmed ID: 15454855
The low molecular weight inhibitor of NCX1 interacts with a cytosolic domain that differs from the ion-transport site of the Na/Ca exchanger.
Biochemical and biophysical research communications Nov, 2004 | Pubmed ID: 15504362
Advanced procedures for separation and analysis of low molecular weight inhibitor (NCXIF) of the cardiac sodium-calcium exchanger.
Biochemical and biophysical research communications Nov, 2005 | Pubmed ID: 16226722
Purified endogenous inhibitor of the Na/Ca exchanger can enhance the cardiomyocytes contractility and calcium transients.
Biochemical and biophysical research communications Aug, 2006 | Pubmed ID: 16782052
Single alpha-domain constructs of the Na+/Ca2+ exchanger, NCLX, oligomerize to form a functional exchanger.
Biochemistry Oct, 2006 | Pubmed ID: 17002286
Effects of purified endogenous inhibitor of the Na+/Ca2+ exchanger on ouabain-induced arrhythmias in the atria and ventricle strips of guinea pig.
European journal of pharmacology Dec, 2006 | Pubmed ID: 17078946
Kinetic and equilibrium properties of regulatory calcium sensors of NCX1 protein.
The Journal of biological chemistry Mar, 2009 | Pubmed ID: 19141619
NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2010 | Pubmed ID: 20018762
Essential role of the CBD1-CBD2 linker in slow dissociation of Ca2+ from the regulatory two-domain tandem of NCX1.
The Journal of biological chemistry Sep, 2010 | Pubmed ID: 20587421
Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger.
The Journal of biological chemistry Aug, 2011 | Pubmed ID: 21680748
Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants.
Cell calcium Jun, 2012 | Pubmed ID: 22571864
A common Ca2+-driven interdomain module governs eukaryotic NCX regulation.
PloS one , 2012 | Pubmed ID: 22768191
G503 is obligatory for coupling of regulatory domains in NCX proteins.
Biochemistry Sep, 2012 | Pubmed ID: 22924554
The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion.
PloS one , 2012 | Pubmed ID: 23056385
Molecular determinants of allosteric regulation in NCX proteins.
Advances in experimental medicine and biology , 2013 | Pubmed ID: 23224868
The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.
Molecular aspects of medicine Apr-Jun, 2013 | Pubmed ID: 23506867
NCLX: the mitochondrial sodium calcium exchanger.
Journal of molecular and cellular cardiology Jun, 2013 | Pubmed ID: 23538132
SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2013 | Pubmed ID: 23589888
Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX).
The Journal of biological chemistry Aug, 2013 | Pubmed ID: 23798674
The C2B domain is the primary Ca2+ sensor in DOC2B: a structural and functional analysis.
Journal of molecular biology Nov, 2013 | Pubmed ID: 23994332
Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions.
Pflugers Archiv : European journal of physiology Jan, 2014 | Pubmed ID: 24281864
Functional asymmetry of bidirectional Ca2+-movements in an archaeal sodium-calcium exchanger (NCX_Mj).
Cell calcium Oct, 2014 | Pubmed ID: 25218934
Structure-dynamic determinants governing a mode of regulatory response and propagation of allosteric signal in splice variants of Na+/Ca2+ exchange (NCX) proteins.
The Biochemical journal Feb, 2015 | Pubmed ID: 25387769
Sodium recognition by the Na+/Ca2+ exchanger in the outward-facing conformation.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2014 | Pubmed ID: 25468964
Structure-dynamic basis of splicing-dependent regulation in tissue-specific variants of the sodium-calcium exchanger.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Mar, 2016 | Pubmed ID: 26644350
Asymmetric Preorganization of Inverted Pair Residues in the Sodium-Calcium Exchanger.
Scientific reports Feb, 2016 | Pubmed ID: 26876271
Structural Features of Ion Transport and Allosteric Regulation in Sodium-Calcium Exchanger (NCX) Proteins.
Frontiers in physiology , 2016 | Pubmed ID: 26903880
Kinetic and equilibrium properties of regulatory Ca(2+)-binding domains in sodium-calcium exchangers 2 and 3.
Cell calcium 04, 2016 | Pubmed ID: 26924806
Structure-Based Engineering of Lithium-Transport Capacity in an Archaeal Sodium-Calcium Exchanger.
Biochemistry Mar, 2016 | Pubmed ID: 26958982
Structure-Functional Basis of Ion Transport in Sodium-Calcium Exchanger (NCX) Proteins.
International journal of molecular sciences Nov, 2016 | Pubmed ID: 27879668
Purification and characterization of human dehydrodolychil diphosphate synthase (DHDDS) overexpressed in E. coli.
Protein expression and purification Apr, 2017 | Pubmed ID: 28167250
Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms.
Scientific reports Apr, 2017 | Pubmed ID: 28428550
Dynamic distinctions in the Na(+)/Ca(2+) exchanger adopting the inward- and outward-facing conformational states.
The Journal of biological chemistry Jul, 2017 | Pubmed ID: 28572509
How a helix imposes palmitoylation of a membrane protein: What one can learn from NCX.
The Journal of biological chemistry Jun, 2017 | Pubmed ID: 28646126
Ilan Edri*,1,
Michal Goldenberg*,1,
Michal Lisnyansky2,
Roi Strulovich2,
Hadas Newman1,3,
Anat Loewenstein1,3,
Daniel Khananshvili2,
Moshe Giladi2,4,
Yoni Haitin2
1Sackler Faculty of Medicine, Tel Aviv University,
2Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University,
3Department of Ophthalmology, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University,
4Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University
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