Alberto Inga

Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.

The coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compound.

Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.

3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro.

Contribution of yeast and plant research for improving human health.

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis.

Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics.

P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements.

Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code.

Comparison of the biological effects of MMS and Me-lex, a minor groove methylating agent: clarifying the role of N3-methyladenine.

Identification of new p53 target microRNAs by bioinformatics and functional analysis.

A cross-platform comparison of affymetrix and Agilent microarrays reveals discordant miRNA expression in lung tumors of c-Raf transgenic mice.

Transcriptional defect of an inherited NKX2-5 haplotype comprising a SNP, a nonsynonymous and a synonymous mutation, associated with human congenital heart disease.

TP53 mutants in the tower of babel of cancer progression.

∆N-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites.

Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.

Cooperative interactions between p53 and NFκB enhance cell plasticity.

Evolution of p53 transactivation specificity through the lens of a yeast-based functional assay.

In-silico identification and functional validation of allele-dependent AR enhancers.

Whole-genome cartography of p53 response elements ranked on transactivation potential.

Quantitative Analysis of NF-κB Transactivation Specificity Using a Yeast-Based Functional Assay.

RiboAbacus: a model trained on polyribosome images predicts ribosome density and translational efficiency from mammalian transcriptomes.

Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas.

Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction.

The 5'-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding.

The CDKN2A/p16(INK) (4a) 5'UTR sequence and translational regulation: impact of novel variants predisposing to melanoma.

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule.

The Ribonucleic Complex HuR-MALAT1 Represses CD133 Expression and Suppresses Epithelial-Mesenchymal Transition in Breast Cancer.

c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.

Human transcription factors in yeast: the fruitful examples of P53 and NF-кB.

The structure formed by inverted repeats in p53 response elements determines the transactivation activity of p53 protein.

DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.

Inherited determinants of early recurrent somatic mutations in prostate cancer.

Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity.

A highly specific SpCas9 variant is identified by in vivo screening in yeast.

Synthesis of 2,6-Diamino-Substituted Purine Derivatives and Evaluation of Cell Cycle Arrest in Breast and Colorectal Cancer Cells.

Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in 53-deficient cancer cells.

LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β.