Department of Biological Sciences
Yongxin (Leon) Zhao is an assistant professor in the Department of Biological Sciences at Carnegie Mellon University in Pittsburgh, Pennsylvania. He received his B.Sc. in Chemistry at Sun Yat-sen University, China. He then joined the Department of Chemistry at University of Alberta, Canada, in 2009. Under the guidance of Professors Robert E. Campbell and D. Jed Harrison, Leon worked on the development of novel directed evolution approaches for improved optogenetic calcium ion and voltage indicators for his doctoral projects. He developed the neuronal imaging tools, GECO and QuasAr families, which have been distributed to and used by hundreds of research groups worldwide. After earning his Ph.D. in 2014, Leon went on and joined Professor Ed Boyden’s lab as a postdoctoral associate at MIT Media lab. In the Boyden lab, he developed a transformative imaging approach, termed Expansion Pathology, for visualization of biomolecules in clinical samples with nanoscale precision using only conventional light microscopes. In the fall of 2017, Leon started his Biophotonics Engineering lab in the Department of Biological Sciences at Carnegie Mellon University.
Leon is a recipient of the National Institutes of Health (NIH) Director’s New Innovator Award. His lab focuses on developing transformative nanoscale imaging techniques that will allow researchers to see precise “biomolecule maps” in pathology samples. These maps will allow for the comprehensive analysis of complex diseases, such as cancer, infection and immune diseases.
Inverse-response Ca indicators for optogenetic visualization of neuronal inhibition.
Scientific reports Aug, 2018 | Pubmed ID: 30082904
Nanoscale Imaging of Kidney Glomeruli Using Expansion Pathology.
Frontiers in medicine , 2018 | Pubmed ID: 30519560
Expansion microscopy: principles and uses in biological research.
Nature methods 01, 2019 | Pubmed ID: 30573813
Basics of Expansion Microscopy.
Current protocols in cytometry Dec, 2019 | Pubmed ID: 31763769
Nanoscale imaging of clinical specimens using conventional and rapid-expansion pathology.
Nature protocols May, 2020 | Pubmed ID: 32238952
Nanoscale imaging of E. coli cells by expansion microscopy.
Discoveries (Craiova, Romania) Sep, 2019 | Pubmed ID: 32309616
Nanoscale Imaging of Synaptic Connections with Expansion Microscopy.
Discoveries (Craiova, Romania) Sep, 2019 | Pubmed ID: 32309619
Expansion Microscopy: Toward Nanoscale Imaging of a Diverse Range of Biomolecules.
ACS nano Jul, 2020 | Pubmed ID: 32628828
Expansion microscopy: A powerful nanoscale imaging tool for neuroscientists.
Neurobiology of disease Jul, 2021 | Pubmed ID: 33813047
Neurophotonic tools for microscopic measurements and manipulation: status report.
Neurophotonics Jan, 2022 | Pubmed ID: 35493335
Super-Resolution Vibrational Imaging Using Expansion Stimulated Raman Scattering Microscopy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) Jul, 2022 | Pubmed ID: 35521971
Three-dimensional nanofabrication via ultrafast laser patterning and kinetically regulated material assembly.
Science (New York, N.Y.) Dec, 2022 | Pubmed ID: 36548430
Magnify is a universal molecular anchoring strategy for expansion microscopy.
Nature biotechnology Jun, 2023 | Pubmed ID: 36593399
MicroMagnify: a multiplexed expansion microscopy method for pathogens and infected tissues.
Research square Mar, 2023 | Pubmed ID: 36945526
Imaging pathology goes nanoscale with a low-cost strategy.
Nature nanotechnology Apr, 2023 | Pubmed ID: 37037894
A New Expansion Microscopy Method Optimized for Microbiology.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada Jul, 2023 | Pubmed ID: 37613535
11-fold Expansion Microscopy with Universal Molecular Retention Using Magnify.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada Jul, 2023 | Pubmed ID: 37613623
MicroMagnify: A Multiplexed Expansion Microscopy Method for Pathogens and Infected Tissues.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) Sep, 2023 | Pubmed ID: 37658522
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