Fabien Gosselet
Laboratory of the Blood Brain Barrier
University of Artois
Fabien Gosselet is the Head of the blood-brain barrier laboratory (BBB-Lab), located in Lens (France) and is full Professor at University of Artois.
He graduated in Cellular Biology and received a PhD in Cancerology (2006) from the Medicine faculty of Paris XI. He completed his education at the BBB-Lab as post-doctoral fellowship. In 2008, he obtained an assistant Professor position at the BBB-Lab and defended his Habilitation in 2014 on links between Blood-brain barrier, neurological disorders and cholesterol metabolism. The 30 members of his lab use house-made in vitro BBB models not only for investigating BBB physiology and its role in neurodegenerative diseases (Alzheimer’s and Parkinson’s diseases, stroke, brain tumor metastasis,…) but also for improving drug delivery and for providing data in pharmaco-toxicological field and to pharmaceutical companies. In 2014, the BBB-lab developed and patented a human in vitro BBB model consisting to co-cultivate human endothelial cells derived from umbilical cord blood stem cells with brain pericytes. This model is now transferred into more than 25 European Labs.
Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model.
Brain research Jan, 2009 | Pubmed ID: 18996096
[Role of the blood-brain barrier in Alzheimer's disease].
Medecine sciences : M/S Nov, 2011 | Pubmed ID: 22130026
Amyloid-β peptides, Alzheimer's disease and the blood-brain barrier.
Current Alzheimer research Dec, 2013 | Pubmed ID: 24156262
Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease.
Biochemical and biophysical research communications Apr, 2014 | Pubmed ID: 24275140
ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier.
International journal of molecular sciences Aug, 2016 | Pubmed ID: 27529215
Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases.
Molecules (Basel, Switzerland) Dec, 2016 | Pubmed ID: 27999408
Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer's Disease.
Molecules (Basel, Switzerland) Feb, 2017 | Pubmed ID: 28208831
A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood-brain barrier under flow.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Mar, 2019 | Pubmed ID: 30565961
Oxysterols and the NeuroVascular Unit (NVU): A far true love with bright and dark sides.
The Journal of steroid biochemistry and molecular biology 07, 2019 | Pubmed ID: 31026511
Central nervous system delivery of molecules across the blood-brain barrier.
Neurochemistry international 03, 2021 | Pubmed ID: 33400964
Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage.
Stem cell research & therapy 10, 2021 | Pubmed ID: 34702368
关于 JoVE
版权所属 © 2024 MyJoVE 公司版权所有，本公司不涉及任何医疗业务和医疗服务。