Rajiv Chopra

Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.

Multifrequency ultrasound transducers for conformal interstitial thermal therapy.

Elongation of synthetic RNA templates by hepatitis C virus NS5B polymerase.

Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.

Multi-modality tissue-mimicking phantom for thermal therapy.

Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.

Method for MRI-guided conformal thermal therapy of prostate with planar transurethral ultrasound heating applicators.

3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.

Analysis of factors important for transurethral ultrasound prostate heating using MR temperature feedback.

A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis.

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.

Molecular mechanism of a thumb domain hepatitis C virus nonnucleoside RNA-dependent RNA polymerase inhibitor.

Acylguanidines as small-molecule beta-secretase inhibitors.

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.

Naphthyl tetronic acids as multi-target inhibitors of bacterial peptidoglycan biosynthesis.

Prostate tissue analysis immediately following magnetic resonance imaging guided transurethral ultrasound thermal therapy.

Thiophene substituted acylguanidines as BACE1 inhibitors.

Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.

Progress in multimodality imaging: truly simultaneous ultrasound and magnetic resonance imaging.

Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.

Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.

MRI-compatible transurethral ultrasound system for the treatment of localized prostate cancer using rotational control.

Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.

In vivo monitoring of focused ultrasound surgery using local harmonic motion.

Crystal structure of human CDK4 in complex with a D-type cyclin.

Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.

Quantitative analysis of 3-D conformal MRI-guided transurethral ultrasound therapy of the prostate: theoretical simulations.

Analysis of the spatial and temporal accuracy of heating in the prostate gland using transurethral ultrasound therapy and active MR temperature feedback.

An MRI-compatible system for focused ultrasound experiments in small animal models.

In vivo MR elastography of the prostate gland using a transurethral actuator.

MR acoustic radiation force imaging: in vivo comparison to ultrasound motion tracking.

MEK1 mutations confer resistance to MEK and B-RAF inhibition.

Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.

Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.

Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors.

Pyridinyl aminohydantoins as small molecule BACE1 inhibitors.

Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.

Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease.

Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures.

Simulation study on the heating of the surrounding anatomy during transurethral ultrasound prostate therapy: a 3D theoretical analysis of patient safety.

MRI-guided transurethral ultrasound therapy of the prostate gland using real-time thermal mapping: initial studies.

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.

Transurethral prostate magnetic resonance elastography: prospective imaging requirements.

3D conformal MRI-controlled transurethral ultrasound prostate therapy: validation of numerical simulations and demonstration in tissue-mimicking gel phantoms.

4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.

MRI-controlled transurethral ultrasound therapy for localised prostate cancer.

Localised drug release using MRI-controlled focused ultrasound hyperthermia.

Development of a platform for co-registered ultrasound and MR contrast imaging in vivo.

The feasibility of endorectal MR elastography for prostate cancer localization.

New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: exploring the S2' region.

Thermally-triggered 'off-on-off' response of gadolinium-hydrogel-lipid hybrid nanoparticles defines a customizable temperature window for non-invasive magnetic resonance imaging thermometry.

Investigation of power and frequency for 3D conformal MRI-controlled transurethral ultrasound therapy with a dual frequency multi-element transducer.

Hyperthermia in Bone Generated with MR Imaging-controlled Focused Ultrasound: Control Strategies and Drug Delivery.