Rajiv Chopra

Imaging Research, Sunnybrook Research Institute

Affiliated withSunnybrook Research Institute University of Toronto

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2012

Other Publications

Article	Year
Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase. The Journal of biological chemistry\| PubMed ID: 11704676	2002
Multifrequency ultrasound transducers for conformal interstitial thermal therapy. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 12894921	2003
Elongation of synthetic RNA templates by hepatitis C virus NS5B polymerase. The Journal of biological chemistry\| PubMed ID: 14688285	2004
Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 15177452	2004
Multi-modality tissue-mimicking phantom for thermal therapy. Physics in medicine and biology\| PubMed ID: 15285246	2004
Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal p... Journal of medicinal chemistry\| PubMed ID: 16078826	2005
Method for MRI-guided conformal thermal therapy of prostate with planar transurethral ultrasound heating applicators. Physics in medicine and biology\| PubMed ID: 16237234	2005
3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria. Antimicrobial agents and chemotherapy\| PubMed ID: 16436710	2006
Analysis of factors important for transurethral ultrasound prostate heating using MR temperature feedback. Physics in medicine and biology\| PubMed ID: 16467581	2006
A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis. Peptides\| PubMed ID: 16574278	2006
Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site. Journal of medicinal chemistry\| PubMed ID: 16722622	2006
Molecular mechanism of a thumb domain hepatitis C virus nonnucleoside RNA-dependent RNA polymerase inhibitor. Antimicrobial agents and chemotherapy\| PubMed ID: 16940072	2006
Acylguanidines as small-molecule beta-secretase inhibitors. Journal of medicinal chemistry\| PubMed ID: 17034121	2006
Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase. Journal of medicinal chemistry\| PubMed ID: 17402724	2007
Naphthyl tetronic acids as multi-target inhibitors of bacterial peptidoglycan biosynthesis. ChemMedChem\| PubMed ID: 17600795	2007
Prostate tissue analysis immediately following magnetic resonance imaging guided transurethral ultrasound thermal therapy. The Journal of urology\| PubMed ID: 17644137	2007
Thiophene substituted acylguanidines as BACE1 inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 17761418	2007
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket. Bioorganic & medicinal chemistry letters\| PubMed ID: 18068983	2008
Progress in multimodality imaging: truly simultaneous ultrasound and magnetic resonance imaging. IEEE transactions on medical imaging\| PubMed ID: 18092742	2007
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets. Bioorganic & medicinal chemistry letters\| PubMed ID: 18162398	2008
Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. Journal of medicinal chemistry\| PubMed ID: 18197612	2008
MRI-compatible transurethral ultrasound system for the treatment of localized prostate cancer using rotational control. Medical physics\| PubMed ID: 18491529	2008
Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796. Antimicrobial agents and chemotherapy\| PubMed ID: 18559648	2008
In vivo monitoring of focused ultrasound surgery using local harmonic motion. Ultrasound in medicine & biology\| PubMed ID: 18805626	2009
Crystal structure of human CDK4 in complex with a D-type cyclin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19237565	2009
Triad of polar residues implicated in pH specificity of acidic mammalian chitinase. Protein science : a publication of the Protein Society\| PubMed ID: 19241384	2009
Quantitative analysis of 3-D conformal MRI-guided transurethral ultrasound therapy of the prostate: theoretical simulations. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 19337912	2009
Analysis of the spatial and temporal accuracy of heating in the prostate gland using transurethral ultrasound therapy and active MR temperature feedback. Physics in medicine and biology\| PubMed ID: 19351975	2009
An MRI-compatible system for focused ultrasound experiments in small animal models. Medical physics\| PubMed ID: 19544806	2009
In vivo MR elastography of the prostate gland using a transurethral actuator. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 19572390	2009
MR acoustic radiation force imaging: in vivo comparison to ultrasound motion tracking. Medical physics\| PubMed ID: 19610290	2009
MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19915144	2009
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 19959359	2010
Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors. Journal of medicinal chemistry\| PubMed ID: 19968289	2010
Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors. Bioorganic & medicinal chemistry\| PubMed ID: 20045648	2010
Pyridinyl aminohydantoins as small molecule BACE1 inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 20202842	2010
Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 20223661	2010
Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease. PloS one\| PubMed ID: 20485502	2010
Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures. ACS chemical neuroscience\| PubMed ID: 20563295	2010
Simulation study on the heating of the surrounding anatomy during transurethral ultrasound prostate therapy: a 3D theoretical analysis of patient safety. Medical physics\| PubMed ID: 20632598	2010
MRI-guided transurethral ultrasound therapy of the prostate gland using real-time thermal mapping: initial studies. Urology\| PubMed ID: 20709381	2010
A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space. Protein science : a publication of the Protein Society\| PubMed ID: 20799349	2010
Transurethral prostate magnetic resonance elastography: prospective imaging requirements. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 20882673	2011
3D conformal MRI-controlled transurethral ultrasound prostate therapy: validation of numerical simulations and demonstration in tissue-mimicking gel phantoms. Physics in medicine and biology\| PubMed ID: 21030751	2010
4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. Journal of medicinal chemistry\| PubMed ID: 21038853	2010
MRI-controlled transurethral ultrasound therapy for localised prostate cancer. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 21043572	2010
Localised drug release using MRI-controlled focused ultrasound hyperthermia. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 21158487	2011
Development of a platform for co-registered ultrasound and MR contrast imaging in vivo. Physics in medicine and biology\| PubMed ID: 21242630	2011
The feasibility of endorectal MR elastography for prostate cancer localization. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 21574182	2011
New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: exploring the S2' region. Bioorganic & medicinal chemistry letters\| PubMed ID: 21835615	2011
Thermally-triggered 'off-on-off' response of gadolinium-hydrogel-lipid hybrid nanoparticles defines a customizable temperature window for non-invasive magnetic resonance imaging thermometry. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21939700	2012
Investigation of power and frequency for 3D conformal MRI-controlled transurethral ultrasound therapy with a dual frequency multi-element transducer. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 22235788	2012
Hyperthermia in Bone Generated with MR Imaging-controlled Focused Ultrasound: Control Strategies and Drug Delivery. Radiology\| PubMed ID: 22344400	2012