Imaging Research
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Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
The Journal of biological chemistry Feb, 2002 | Pubmed ID: 11704676
Multifrequency ultrasound transducers for conformal interstitial thermal therapy.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control Jul, 2003 | Pubmed ID: 12894921
Elongation of synthetic RNA templates by hepatitis C virus NS5B polymerase.
The Journal of biological chemistry Mar, 2004 | Pubmed ID: 14688285
Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.
Bioorganic & medicinal chemistry letters Jul, 2004 | Pubmed ID: 15177452
Multi-modality tissue-mimicking phantom for thermal therapy.
Physics in medicine and biology Jul, 2004 | Pubmed ID: 15285246
Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.
Journal of medicinal chemistry Aug, 2005 | Pubmed ID: 16078826
Method for MRI-guided conformal thermal therapy of prostate with planar transurethral ultrasound heating applicators.
Physics in medicine and biology Nov, 2005 | Pubmed ID: 16237234
3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.
Antimicrobial agents and chemotherapy Feb, 2006 | Pubmed ID: 16436710
Analysis of factors important for transurethral ultrasound prostate heating using MR temperature feedback.
Physics in medicine and biology Feb, 2006 | Pubmed ID: 16467581
A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis.
Peptides Jul, 2006 | Pubmed ID: 16574278
Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.
Journal of medicinal chemistry Jun, 2006 | Pubmed ID: 16722622
Molecular mechanism of a thumb domain hepatitis C virus nonnucleoside RNA-dependent RNA polymerase inhibitor.
Antimicrobial agents and chemotherapy Dec, 2006 | Pubmed ID: 16940072
Acylguanidines as small-molecule beta-secretase inhibitors.
Journal of medicinal chemistry Oct, 2006 | Pubmed ID: 17034121
Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.
Journal of medicinal chemistry May, 2007 | Pubmed ID: 17402724
Naphthyl tetronic acids as multi-target inhibitors of bacterial peptidoglycan biosynthesis.
ChemMedChem Oct, 2007 | Pubmed ID: 17600795
Prostate tissue analysis immediately following magnetic resonance imaging guided transurethral ultrasound thermal therapy.
The Journal of urology Sep, 2007 | Pubmed ID: 17644137
Thiophene substituted acylguanidines as BACE1 inhibitors.
Bioorganic & medicinal chemistry letters Oct, 2007 | Pubmed ID: 17761418
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.
Bioorganic & medicinal chemistry letters Jan, 2008 | Pubmed ID: 18068983
Progress in multimodality imaging: truly simultaneous ultrasound and magnetic resonance imaging.
IEEE transactions on medical imaging Dec, 2007 | Pubmed ID: 18092742
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Bioorganic & medicinal chemistry letters Feb, 2008 | Pubmed ID: 18162398
Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
Journal of medicinal chemistry Feb, 2008 | Pubmed ID: 18197612
MRI-compatible transurethral ultrasound system for the treatment of localized prostate cancer using rotational control.
Medical physics Apr, 2008 | Pubmed ID: 18491529
Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.
Antimicrobial agents and chemotherapy Sep, 2008 | Pubmed ID: 18559648
In vivo monitoring of focused ultrasound surgery using local harmonic motion.
Ultrasound in medicine & biology Jan, 2009 | Pubmed ID: 18805626
Crystal structure of human CDK4 in complex with a D-type cyclin.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19237565
Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.
Protein science : a publication of the Protein Society Mar, 2009 | Pubmed ID: 19241384
Quantitative analysis of 3-D conformal MRI-guided transurethral ultrasound therapy of the prostate: theoretical simulations.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group Mar, 2009 | Pubmed ID: 19337912
Analysis of the spatial and temporal accuracy of heating in the prostate gland using transurethral ultrasound therapy and active MR temperature feedback.
Physics in medicine and biology May, 2009 | Pubmed ID: 19351975
An MRI-compatible system for focused ultrasound experiments in small animal models.
Medical physics May, 2009 | Pubmed ID: 19544806
In vivo MR elastography of the prostate gland using a transurethral actuator.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Sep, 2009 | Pubmed ID: 19572390
MR acoustic radiation force imaging: in vivo comparison to ultrasound motion tracking.
Medical physics Jun, 2009 | Pubmed ID: 19610290
MEK1 mutations confer resistance to MEK and B-RAF inhibition.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2009 | Pubmed ID: 19915144
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.
Bioorganic & medicinal chemistry letters Jan, 2010 | Pubmed ID: 19959359
Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
Journal of medicinal chemistry Feb, 2010 | Pubmed ID: 19968289
Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors.
Bioorganic & medicinal chemistry Jan, 2010 | Pubmed ID: 20045648
Pyridinyl aminohydantoins as small molecule BACE1 inhibitors.
Bioorganic & medicinal chemistry letters Apr, 2010 | Pubmed ID: 20202842
Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.
Bioorganic & medicinal chemistry letters Apr, 2010 | Pubmed ID: 20223661
Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease.
PloS one , 2010 | Pubmed ID: 20485502
Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures.
ACS chemical neuroscience May, 2010 | Pubmed ID: 20563295
Simulation study on the heating of the surrounding anatomy during transurethral ultrasound prostate therapy: a 3D theoretical analysis of patient safety.
Medical physics Jun, 2010 | Pubmed ID: 20632598
MRI-guided transurethral ultrasound therapy of the prostate gland using real-time thermal mapping: initial studies.
Urology Dec, 2010 | Pubmed ID: 20709381
A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.
Protein science : a publication of the Protein Society Nov, 2010 | Pubmed ID: 20799349
Transurethral prostate magnetic resonance elastography: prospective imaging requirements.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Feb, 2011 | Pubmed ID: 20882673
3D conformal MRI-controlled transurethral ultrasound prostate therapy: validation of numerical simulations and demonstration in tissue-mimicking gel phantoms.
Physics in medicine and biology Nov, 2010 | Pubmed ID: 21030751
4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.
Journal of medicinal chemistry Nov, 2010 | Pubmed ID: 21038853
MRI-controlled transurethral ultrasound therapy for localised prostate cancer.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group , 2010 | Pubmed ID: 21043572
Localised drug release using MRI-controlled focused ultrasound hyperthermia.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group , 2011 | Pubmed ID: 21158487
Development of a platform for co-registered ultrasound and MR contrast imaging in vivo.
Physics in medicine and biology Feb, 2011 | Pubmed ID: 21242630
The feasibility of endorectal MR elastography for prostate cancer localization.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Dec, 2011 | Pubmed ID: 21574182
New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: exploring the S2' region.
Bioorganic & medicinal chemistry letters Sep, 2011 | Pubmed ID: 21835615
Thermally-triggered 'off-on-off' response of gadolinium-hydrogel-lipid hybrid nanoparticles defines a customizable temperature window for non-invasive magnetic resonance imaging thermometry.
Journal of controlled release : official journal of the Controlled Release Society Feb, 2012 | Pubmed ID: 21939700
Investigation of power and frequency for 3D conformal MRI-controlled transurethral ultrasound therapy with a dual frequency multi-element transducer.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group , 2012 | Pubmed ID: 22235788
Hyperthermia in Bone Generated with MR Imaging-controlled Focused Ultrasound: Control Strategies and Drug Delivery.
Radiology Feb, 2012 | Pubmed ID: 22344400
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