Matt Kaeberlein

Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity.

Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity.

AGEID: a database of aging genes and interventions.

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.

High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction.

Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism.

Sir2-independent life span extension by calorie restriction in yeast.

Aging-related research in the "-omics" age.

Large-scale identification in yeast of conserved ageing genes.

Substrate-specific activation of sirtuins by resveratrol.

Genes determining yeast replicative life span in a long-lived genetic background.

The enigmatic role of Sir2 in aging.

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.

Increased life span due to calorie restriction in respiratory-deficient yeast.

Extension of chronological life span in yeast by decreased TOR pathway signaling.

Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction".

Genome-wide approaches to understanding human ageing.

Lifespan extension in Caenorhabditis elegans by complete removal of food.

Medicine: grapes versus gluttony.

Genome-wide identification of conserved longevity genes in yeast and worms.

Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.

The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function.

Sir2 and calorie restriction in yeast: a skeptical perspective.

Recent developments in yeast aging.

Does resveratrol activate yeast Sir2 in vivo?

Molecular basis of ageing.

Protein translation, 2007.

Single-gene deletions that restore mating competence to diploid yeast.

Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes.

A method for high-throughput quantitative analysis of yeast chronological life span.

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America.

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans.

The ongoing saga of sirtuins and aging.

Longevity genomics across species.

Cell biology: A molecular age barrier.

Protein translation, 2008.

Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.

A molecular mechanism of chronological aging in yeast.

Proteasomal regulation of the hypoxic response modulates aging in C. elegans.

Histone H4 lysine 16 acetylation regulates cellular lifespan.

A genomic approach to yeast chronological aging.

The TOR pathway comes of age.

Ageing: A midlife longevity drug?

The hypoxic response and aging.

Hot topics in aging research: protein translation, 2009.

Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.

Cell signaling. Aging is RSKy business.

Spermidine surprise for a long life.

Resveratrol and rapamycin: are they anti-aging drugs?

YODA: software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast.

Lessons on longevity from budding yeast.

A role for SIRT1 in the hypoxic response.

The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging.

Regulation of mRNA translation as a conserved mechanism of longevity control.

Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix.

Hot topics in aging research: protein translation and TOR signaling, 2010.

Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast.

HIF-1 modulates longevity and healthspan in a temperature-dependent manner.

A genomic analysis of chronological longevity factors in budding yeast.

Trinations aging symposium.

Sir2 deletion prevents lifespan extension in 32 long-lived mutants.

Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae.

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.

Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast.

Genome-wide analysis of yeast aging.

The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans.

A new chronological survival assay in mammalian cell culture.

Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae.

Midlife gene expressions identify modulators of aging through dietary interventions.

Replicative and chronological aging in Saccharomyces cerevisiae.

Yeast as a model to understand the interaction between genotype and the response to calorie restriction.

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast.

Elevated MTORC1 signaling and impaired autophagy.

Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.

Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae.

mTOR is a key modulator of ageing and age-related disease.

End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging.

Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1.

A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.

Longevity and aging.

Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans.

Molecular mechanisms underlying genotype-dependent responses to dietary restriction.

The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.

Yeast replicative aging: a paradigm for defining conserved longevity interventions.

Preserving youth: does rapamycin deliver?

Deciphering the role of natural variation in age-related protein homeostasis.

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin.

mTOR Inhibition: From Aging to Autism and Beyond.

Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response.

Development. Chemical warfare in the battle of the sexes.

Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase.

The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?

Buffering the pH of the culture medium does not extend yeast replicative lifespan.

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans.

Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans.

Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response.

Rejuvenation: it's in our blood.

The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.

A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer.

Replicative life span analysis in budding yeast.

Rapamycin and ageing: when, for how long, and how much?

Modulating mTOR in aging and health.

Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism.

Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import.

Fertile waters for aging research.

Why is aging conserved and what can we do about it?

PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae.

MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts.

The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects.

H3K36 methylation promotes longevity by enhancing transcriptional fidelity.

Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.

Transcription errors induce proteotoxic stress and shorten cellular lifespan.

Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry.

Searching for the elusive mitochondrial longevity signal in C. elegans.

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.

Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein.

Biochemical Genetic Pathways that Modulate Aging in Multiple Species.

Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans.

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span.

Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae.

Healthy aging: The ultimate preventative medicine.

Microfluidic technologies for yeast replicative lifespan studies.

Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates.

The dog aging project: translational geroscience in companion animals.

New functional and biophysical insights into the mitochondrial Rieske iron-sulfur protein from genetic suppressor analysis in C. elegans.

New insights into cell non-autonomous mechanisms of the C. elegans hypoxic response.

Rapamycin in aging and disease: maximizing efficacy while minimizing side effects.

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.

Age-associated vulval integrity is an important marker of nematode healthspan.

Rapamycin enhances survival in a Drosophila model of mitochondrial disease.

Dietary restriction and lifespan: Lessons from invertebrate models.

CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes.

Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.

Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging.

Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.

Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans.

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs.

Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes.

Inter-organ regulation of haem homeostasis.

A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae.

Rapamycin treatment attenuates age-associated periodontitis in mice.

Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.

Genetic interaction with temperature is an important determinant of nematode longevity.

Electrophysiological Measures of Aging Pharynx Function in C. elegans Reveal Enhanced Organ Functionality in Older, Long-lived Mutants.

Oral health in geroscience: animal models and the aging oral cavity.

Corrigendum: Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.

The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells.

Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in .

How healthy is the healthspan concept?

Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.

Research to Promote Longevity and Health Span in Companion Dogs: A Pediatric Perspective.

mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases.

Rapamycin and Alzheimer's disease: Time for a clinical trial?

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.

Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics.

In vivo measurements reveal a single 5'-intron is sufficient to increase protein expression level in Caenorhabditis elegans.

Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of .

Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging.

An inexpensive microscopy system for microfluidic studies in budding yeast.

Cross species application of quantitative neuropathology assays developed for clinical Alzheimer's disease samples.

DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging.

WormBot, an open-source robotics platform for survival and behavior analysis in C. elegans.

Latest advances in aging research and drug discovery.

Desexing Dogs: A Review of the Current Literature.

Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins.

Loss of vacuolar acidity results in iron-sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae.

The antifungal plant defensin HsAFP1 induces autophagy, vacuolar dysfunction and cell cycle impairment in yeast.

DDS promotes longevity through a microbiome-mediated starvation signal.

Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast.

Translational geroscience: A new paradigm for 21 century medicine.