Eukaryotic Pathogens Innovation Center
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Glycerol 3-phosphate alters Trypanosoma brucei hexokinase activity in response to environmental change.
The Journal of biological chemistry Sep, 2011 | Pubmed ID: 21813651
Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic development.
Molecular biology international , 2011 | Pubmed ID: 22091393
Extra-glycosomal localisation of Trypanosoma brucei hexokinase 2.
International journal for parasitology Apr, 2012 | Pubmed ID: 22619756
Peptide-targeted delivery of a pH sensor for quantitative measurements of intraglycosomal pH in live Trypanosoma brucei.
Biochemistry May, 2013 | Pubmed ID: 23651061
Environmentally regulated glycosome protein composition in the African trypanosome.
Eukaryotic cell Aug, 2013 | Pubmed ID: 23709182
Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase.
Antimicrobial agents and chemotherapy Aug, 2013 | Pubmed ID: 23716053
Targeting protozoan parasite metabolism: glycolytic enzymes in the therapeutic crosshairs.
Current medicinal chemistry , 2014 | Pubmed ID: 24083603
Exploring the mode of action of ebselen in Trypanosoma brucei hexokinase inhibition.
International journal for parasitology. Drugs and drug resistance Dec, 2013 | Pubmed ID: 24533305
Characterization of an African trypanosome mutant refractory to lectin-induced death.
Biochemistry and biophysics reports Dec, 2015 | Pubmed ID: 26393238
Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity.
Antimicrobial agents and chemotherapy Oct, 2016 | Pubmed ID: 27458230
Evaluation of substituted ebselen derivatives as potential trypanocidal agents.
Bioorganic & medicinal chemistry letters Feb, 2017 | Pubmed ID: 28043795
Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids.
Bioorganic & medicinal chemistry letters Feb, 2017 | Pubmed ID: 28119024
pH regulation in glycosomes of procyclic form .
The Journal of biological chemistry May, 2017 | Pubmed ID: 28348078
A targeted delivery strategy for the development of potent trypanocides.
Chemical communications (Cambridge, England) Aug, 2017 | Pubmed ID: 28726862
Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1.
ChemMedChem Dec, 2017 | Pubmed ID: 29105342
A FRET flow cytometry method for monitoring cytosolic and glycosomal glucose in living kinetoplastid parasites.
PLoS neglected tropical diseases May, 2018 | Pubmed ID: 29851949
Glucose Signaling Is Important for Nutrient Adaptation during Differentiation of Pleomorphic African Trypanosomes.
mSphere Oct, 2018 | Pubmed ID: 30381351
A Microfluidic-Based Microscopy Platform for Continuous Interrogation of Trypanosoma brucei during Environmental Perturbation.
Biochemistry Feb, 2019 | Pubmed ID: 30638014
Enzymatic and Structural Characterization of the Glucokinase.
Antimicrobial agents and chemotherapy May, 2019 | Pubmed ID: 30783001
and human hexokinases share similar active sites but display distinct quaternary architectures.
IUCrJ May, 2020 | Pubmed ID: 32431829
Dual-Stage Picolinic Acid-Derived Inhibitors of .
ACS medicinal chemistry letters Dec, 2020 | Pubmed ID: 33335660
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba.
PloS one , 2021 | Pubmed ID: 33760815
The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design.
Scientific reports Nov, 2021 | Pubmed ID: 34737367
Glucose metabolism in the pathogenic free-living amoebae: Tempting targets for treatment development.
Chemical biology & drug design Jan, 2024 | Pubmed ID: 37864277
Enolase Inhibitors as Early Lead Therapeutics against .
Pathogens (Basel, Switzerland) Oct, 2023 | Pubmed ID: 38003754
Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic "Brain-Eating" Amoeba.
ACS medicinal chemistry letters Jan, 2024 | Pubmed ID: 38229759
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