James C. Morris

Eukaryotic Pathogens Innovation Center, Clemson University

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2024

Other Publications

Article	Year
Glycerol 3-phosphate alters Trypanosoma brucei hexokinase activity in response to environmental change. The Journal of biological chemistry\| PubMed ID: 21813651	2011
Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic development. Molecular biology international\| PubMed ID: 22091393	2011
Extra-glycosomal localisation of Trypanosoma brucei hexokinase 2. International journal for parasitology\| PubMed ID: 22619756	2012
Peptide-targeted delivery of a pH sensor for quantitative measurements of intraglycosomal pH in live Trypanosoma brucei. Biochemistry\| PubMed ID: 23651061	2013
Environmentally regulated glycosome protein composition in the African trypanosome. Eukaryotic cell\| PubMed ID: 23709182	2013
Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase. Antimicrobial agents and chemotherapy\| PubMed ID: 23716053	2013
Targeting protozoan parasite metabolism: glycolytic enzymes in the therapeutic crosshairs. Current medicinal chemistry\| PubMed ID: 24083603	2014
Exploring the mode of action of ebselen in Trypanosoma brucei hexokinase inhibition. International journal for parasitology. Drugs and drug resistance\| PubMed ID: 24533305	2013
Characterization of an African trypanosome mutant refractory to lectin-induced death. Biochemistry and biophysics reports\| PubMed ID: 26393238	2015
Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity. Antimicrobial agents and chemotherapy\| PubMed ID: 27458230	2016
Evaluation of substituted ebselen derivatives as potential trypanocidal agents. Bioorganic & medicinal chemistry letters\| PubMed ID: 28043795	2017
Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids. Bioorganic & medicinal chemistry letters\| PubMed ID: 28119024	2017
pH regulation in glycosomes of procyclic form . The Journal of biological chemistry\| PubMed ID: 28348078	2017
A targeted delivery strategy for the development of potent trypanocides. Chemical communications (Cambridge, England)\| PubMed ID: 28726862	2017
Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1. ChemMedChem\| PubMed ID: 29105342	2017
A FRET flow cytometry method for monitoring cytosolic and glycosomal glucose in living kinetoplastid parasites. PLoS neglected tropical diseases\| PubMed ID: 29851949	2018
Glucose Signaling Is Important for Nutrient Adaptation during Differentiation of Pleomorphic African Trypanosomes. mSphere\| PubMed ID: 30381351	2018
A Microfluidic-Based Microscopy Platform for Continuous Interrogation of Trypanosoma brucei during Environmental Perturbation. Biochemistry\| PubMed ID: 30638014	2019
Enzymatic and Structural Characterization of the Glucokinase. Antimicrobial agents and chemotherapy\| PubMed ID: 30783001	2019
and human hexokinases share similar active sites but display distinct quaternary architectures. IUCrJ\| PubMed ID: 32431829	2020
Dual-Stage Picolinic Acid-Derived Inhibitors of . ACS medicinal chemistry letters\| PubMed ID: 33335660	2020
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba. PloS one\| PubMed ID: 33760815	2021
The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design. Scientific reports\| PubMed ID: 34737367	2021
Glucose metabolism in the pathogenic free-living amoebae: Tempting targets for treatment development. Chemical biology & drug design\| PubMed ID: 37864277	2024
Enolase Inhibitors as Early Lead Therapeutics against . Pathogens (Basel, Switzerland)\| PubMed ID: 38003754	2023
Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic "Brain-Eating" Amoeba. ACS medicinal chemistry letters\| PubMed ID: 38229759	2024