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Eukaryotic Pathogens Innovation Center
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Glycerol 3-phosphate alters Trypanosoma brucei hexokinase activity in response to environmental change.
The Journal of biological chemistry Sep, 2011 | Pubmed ID: 21813651
Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic development.
Molecular biology international , 2011 | Pubmed ID: 22091393
Extra-glycosomal localisation of Trypanosoma brucei hexokinase 2.
International journal for parasitology Apr, 2012 | Pubmed ID: 22619756
Peptide-targeted delivery of a pH sensor for quantitative measurements of intraglycosomal pH in live Trypanosoma brucei.
Biochemistry May, 2013 | Pubmed ID: 23651061
Environmentally regulated glycosome protein composition in the African trypanosome.
Eukaryotic cell Aug, 2013 | Pubmed ID: 23709182
Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase.
Antimicrobial agents and chemotherapy Aug, 2013 | Pubmed ID: 23716053
Targeting protozoan parasite metabolism: glycolytic enzymes in the therapeutic crosshairs.
Current medicinal chemistry , 2014 | Pubmed ID: 24083603
Exploring the mode of action of ebselen in Trypanosoma brucei hexokinase inhibition.
International journal for parasitology. Drugs and drug resistance Dec, 2013 | Pubmed ID: 24533305
Characterization of an African trypanosome mutant refractory to lectin-induced death.
Biochemistry and biophysics reports Dec, 2015 | Pubmed ID: 26393238
Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity.
Antimicrobial agents and chemotherapy Oct, 2016 | Pubmed ID: 27458230
Evaluation of substituted ebselen derivatives as potential trypanocidal agents.
Bioorganic & medicinal chemistry letters Feb, 2017 | Pubmed ID: 28043795
Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids.
Bioorganic & medicinal chemistry letters Feb, 2017 | Pubmed ID: 28119024
pH regulation in glycosomes of procyclic form .
The Journal of biological chemistry May, 2017 | Pubmed ID: 28348078
A targeted delivery strategy for the development of potent trypanocides.
Chemical communications (Cambridge, England) Aug, 2017 | Pubmed ID: 28726862
Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1.
ChemMedChem Dec, 2017 | Pubmed ID: 29105342
A FRET flow cytometry method for monitoring cytosolic and glycosomal glucose in living kinetoplastid parasites.
PLoS neglected tropical diseases May, 2018 | Pubmed ID: 29851949
Glucose Signaling Is Important for Nutrient Adaptation during Differentiation of Pleomorphic African Trypanosomes.
mSphere Oct, 2018 | Pubmed ID: 30381351
A Microfluidic-Based Microscopy Platform for Continuous Interrogation of Trypanosoma brucei during Environmental Perturbation.
Biochemistry Feb, 2019 | Pubmed ID: 30638014
Enzymatic and Structural Characterization of the Glucokinase.
Antimicrobial agents and chemotherapy May, 2019 | Pubmed ID: 30783001
and human hexokinases share similar active sites but display distinct quaternary architectures.
IUCrJ May, 2020 | Pubmed ID: 32431829
Dual-Stage Picolinic Acid-Derived Inhibitors of .
ACS medicinal chemistry letters Dec, 2020 | Pubmed ID: 33335660
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba.
PloS one , 2021 | Pubmed ID: 33760815
The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design.
Scientific reports Nov, 2021 | Pubmed ID: 34737367
Glucose metabolism in the pathogenic free-living amoebae: Tempting targets for treatment development.
Chemical biology & drug design Jan, 2024 | Pubmed ID: 37864277
Enolase Inhibitors as Early Lead Therapeutics against .
Pathogens (Basel, Switzerland) Oct, 2023 | Pubmed ID: 38003754
Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic "Brain-Eating" Amoeba.
ACS medicinal chemistry letters Jan, 2024 | Pubmed ID: 38229759
Clemson University
Daniel Call*,1,
Sabrina S. Pizarro*,2,3,
Erica Tovey1,
Emily Knight2,3,
Carrie Baumgardner2,4,
Kenneth A. Christensen1,
James C. Morris2
1Department Chemistry and Biochemistry, Brigham Young University,
2Eukaryotic Pathogens Innovation Center, Clemson University,
3Department of Genetics and Biochemistry, Clemson University,
4Department of Physics and Astronomy, Clemson University
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