Yuri K. Peterson

Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking.

The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis.

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.

Characterization of isoenzyme-selective inhibitors of human sphingosine kinases.

High-throughput screening for novel inhibitors of Neisseria gonorrhoeae penicillin-binding protein 2.

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.

A high-content, live-cell, and real-time approach to the quantitation of ligand-induced β-Arrestin2 and Class A/Class B GPCR mobilization.

Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity.

The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers.

High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury.

β2-Adrenoceptor agonists in the regulation of mitochondrial biogenesis.

Suppression of GNAI2 message in ovarian cancer.

Development of inhibitors of heterotrimeric Gαi subunits.

Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning.

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions.

Docking optimization, variance and promiscuity for large-scale drug-like chemical space using high performance computing architectures.

Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia.

Comparison of the Deacylase and Deacetylase Activity of Zinc-Dependent HDACs.

The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.

Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis.

Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.

Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status.

Genetic Variants of and Are Determinants of Survival in Renal Cell Carcinoma Patients Treated with Sorafenib.

The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction.

Author Correction: Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.

Dual inhibitors of LSD1 and spermine oxidase.

Development of a Novel Humanized Monoclonal Antibody to Secreted Frizzled-Related Protein-2 That Inhibits Triple-Negative Breast Cancer and Angiosarcoma Growth In Vivo.

Design of Hydrazide-Bearing HDACIs Based on Panobinostat and Their p53 and FLT3-ITD Dependency in Antileukemia Activity.

Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non-small cell lung cancer.

Newly Identified Chemicals Preserve Mitochondrial Capacity and Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models.

The Chemical Relationship Among Beta-Lactam Antibiotics and Potential Impacts on Reactivity and Decomposition.

Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells.

Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation.

Identification and Characterization of Novel Small-Molecule SMOX Inhibitors.

Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma.

Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis.

Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma.

A human iPSC-derived hepatocyte screen identifies compounds that inhibit production of Apolipoprotein B.

Inhibition of complement C3 prevents osteoarthritis progression in guinea pigs by blocking STAT1 activation.

First analytical confirmation of drug-induced crystal nephropathy in felines caused by GS-441524, the active metabolite of Remdesivir.