Drug Discovery and Biomedical Sciences
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Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking.
Neuron Apr, 2004 | Pubmed ID: 15091342
The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis.
The Journal of pharmacology and experimental therapeutics Jul, 2012 | Pubmed ID: 22490378
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
Nature chemical biology Oct, 2012 | Pubmed ID: 22922758
Characterization of isoenzyme-selective inhibitors of human sphingosine kinases.
PloS one , 2012 | Pubmed ID: 22970244
High-throughput screening for novel inhibitors of Neisseria gonorrhoeae penicillin-binding protein 2.
PloS one , 2012 | Pubmed ID: 23049763
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.
EMBO molecular medicine Jan, 2013 | Pubmed ID: 23180565
A high-content, live-cell, and real-time approach to the quantitation of ligand-induced β-Arrestin2 and Class A/Class B GPCR mobilization.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada Feb, 2013 | Pubmed ID: 23351552
Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity.
Methods in enzymology , 2013 | Pubmed ID: 23374189
The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers.
The Journal of biological chemistry Jun, 2013 | Pubmed ID: 23661707
High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury.
Toxicology and applied pharmacology Oct, 2013 | Pubmed ID: 23811330
β2-Adrenoceptor agonists in the regulation of mitochondrial biogenesis.
Bioorganic & medicinal chemistry letters Oct, 2013 | Pubmed ID: 23954364
Suppression of GNAI2 message in ovarian cancer.
Journal of ovarian research Jan, 2014 | Pubmed ID: 24423449
Development of inhibitors of heterotrimeric Gαi subunits.
Bioorganic & medicinal chemistry Jul, 2014 | Pubmed ID: 24818958
Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning.
Biochimica et biophysica acta Feb, 2015 | Pubmed ID: 25447550
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.
Science signaling Jun, 2015 | Pubmed ID: 26082434
The conformational signature of β-arrestin2 predicts its trafficking and signalling functions.
Nature Mar, 2016 | Pubmed ID: 27007854
Docking optimization, variance and promiscuity for large-scale drug-like chemical space using high performance computing architectures.
Drug discovery today Oct, 2016 | Pubmed ID: 27352630
Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia.
Journal of medicinal chemistry Nov, 2016 | Pubmed ID: 27754681
Comparison of the Deacylase and Deacetylase Activity of Zinc-Dependent HDACs.
ACS chemical biology Jun, 2017 | Pubmed ID: 28459537
The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.
Pharmacological reviews Jul, 2017 | Pubmed ID: 28626043
Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis.
Angiogenesis Nov, 2017 | Pubmed ID: 28840375
Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.
Scientific reports Sep, 2017 | Pubmed ID: 28874749
Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.
Nature communications Nov, 2017 | Pubmed ID: 29142209
Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status.
Journal of medicinal chemistry Mar, 2018 | Pubmed ID: 29499113
Genetic Variants of and Are Determinants of Survival in Renal Cell Carcinoma Patients Treated with Sorafenib.
Cancer research Jan, 2019 | Pubmed ID: 30385613
The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jun, 2019 | Pubmed ID: 30917007
Author Correction: Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.
Scientific reports May, 2019 | Pubmed ID: 31043635
Dual inhibitors of LSD1 and spermine oxidase.
MedChemComm May, 2019 | Pubmed ID: 31191868
Development of a Novel Humanized Monoclonal Antibody to Secreted Frizzled-Related Protein-2 That Inhibits Triple-Negative Breast Cancer and Angiosarcoma Growth In Vivo.
Annals of surgical oncology Dec, 2019 | Pubmed ID: 31515721
Design of Hydrazide-Bearing HDACIs Based on Panobinostat and Their p53 and FLT3-ITD Dependency in Antileukemia Activity.
Journal of medicinal chemistry May, 2020 | Pubmed ID: 32321249
Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non-small cell lung cancer.
The Journal of thoracic and cardiovascular surgery Aug, 2021 | Pubmed ID: 32653291
Newly Identified Chemicals Preserve Mitochondrial Capacity and Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics , 2021 | Pubmed ID: 33945330
The Chemical Relationship Among Beta-Lactam Antibiotics and Potential Impacts on Reactivity and Decomposition.
Frontiers in microbiology , 2022 | Pubmed ID: 35401470
Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Jun, 2022 | Pubmed ID: 35447542
Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation.
RSC advances Oct, 2021 | Pubmed ID: 35497564
Identification and Characterization of Novel Small-Molecule SMOX Inhibitors.
Medical sciences (Basel, Switzerland) Aug, 2022 | Pubmed ID: 36135832
Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma.
European journal of medicinal chemistry Dec, 2022 | Pubmed ID: 36223680
Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis.
Cell reports Dec, 2022 | Pubmed ID: 36476873
Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma.
Chemical science Feb, 2023 | Pubmed ID: 36845935
A human iPSC-derived hepatocyte screen identifies compounds that inhibit production of Apolipoprotein B.
Communications biology Apr, 2023 | Pubmed ID: 37095219
Inhibition of complement C3 prevents osteoarthritis progression in guinea pigs by blocking STAT1 activation.
Communications biology Mar, 2024 | Pubmed ID: 38538870
First analytical confirmation of drug-induced crystal nephropathy in felines caused by GS-441524, the active metabolite of Remdesivir.
Journal of pharmaceutical and biomedical analysis Sep, 2024 | Pubmed ID: 38823223
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