Department of Surgery,
Institute of Medical Science,
Institute of Biomaterials and Biomedical Engineering,
Division of Anatomy,
Institute of Biomedical Engineering,
Donnelly Centre for Cellular and Biomedical Research,
Department of Surgery, Division of Anatomy
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Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations.
Nature medicine Mar, 2002 | Pubmed ID: 11875498
The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells.
The European journal of neuroscience Jul, 2003 | Pubmed ID: 12859339
Distinct populations of forebrain neural stem and progenitor cells can be isolated using side-population analysis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2003 | Pubmed ID: 14627655
Disguising adult neural stem cells.
Current opinion in neurobiology Feb, 2004 | Pubmed ID: 15018948
Adult neural stem cells: attempting to solve the identity crisis.
Developmental neuroscience Mar-Aug, 2004 | Pubmed ID: 15711053
Incorporation of protein-eluting microspheres into biodegradable nerve guidance channels for controlled release.
Journal of controlled release : official journal of the Controlled Release Society Jan, 2006 | Pubmed ID: 16325953
Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2006 | Pubmed ID: 16571744
Exploiting the properties of adult stem cells for the treatment of disease.
Current opinion in molecular therapeutics Aug, 2006 | Pubmed ID: 16955696
Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells.
The Journal of cell biology Oct, 2006 | Pubmed ID: 17030986
True monolayer cell culture in a confined 3D microenvironment enables lineage informatics.
Cytometry. Part A : the journal of the International Society for Analytical Cytology Dec, 2006 | Pubmed ID: 17066473
Extramedullary chitosan channels promote survival of transplanted neural stem and progenitor cells and create a tissue bridge after complete spinal cord transection.
Tissue engineering. Part A May, 2008 | Pubmed ID: 18419246
Delayed implantation of intramedullary chitosan channels containing nerve grafts promotes extensive axonal regeneration after spinal cord injury.
Neurosurgery Jul, 2008 | Pubmed ID: 18728578
Don't look: growing clonal versus nonclonal neural stem cell colonies.
Stem cells (Dayton, Ohio) Nov, 2008 | Pubmed ID: 18757294
Neurogenic potential of isolated precursor cells from early post-gastrula somitic tissue.
Stem cells and development Dec, 2009 | Pubmed ID: 19326969
Cyclosporin A has direct effects on adult neural precursor cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2010 | Pubmed ID: 20181586
Potential and pitfalls of stem cell therapy in old age.
Disease models & mechanisms Jul-Aug, 2010 | Pubmed ID: 20504968
Endogenous radial glial cells support regenerating axons after spinal cord transection.
Neuroreport Sep, 2010 | Pubmed ID: 20671580
Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury.
Experimental neurology Jul, 2011 | Pubmed ID: 20685361
Transport of epidermal growth factor in the stroke-injured brain.
Journal of controlled release : official journal of the Controlled Release Society Feb, 2011 | Pubmed ID: 21035512
Wnt signaling regulates symmetry of division of neural stem cells in the adult brain and in response to injury.
Stem cells (Dayton, Ohio) Mar, 2011 | Pubmed ID: 21425415
Adult stem cells and bioengineering strategies for the treatment of cerebral ischemic stroke.
Current stem cell research & therapy Sep, 2011 | Pubmed ID: 21476981
Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain.
Biomaterials Aug, 2011 | Pubmed ID: 21550655
Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels.
Nature materials Oct, 2011 | Pubmed ID: 21874004
Adult subependymal neural precursors, but not differentiated cells, undergo rapid cathodal migration in the presence of direct current electric fields.
PloS one , 2011 | Pubmed ID: 21909360
Hydrogel delivery of erythropoietin to the brain for endogenous stem cell stimulation after stroke injury.
Biomaterials Mar, 2012 | Pubmed ID: 22217804
The Effect of Growth Factors and Soluble Nogo66 Receptor Protein on Transplanted Neural Stem/Progenitor Survival and Axonal Regeneration after Complete Transection of Rat Spinal Cord.
Cell transplantation Jan, 2012 | Pubmed ID: 22236767
Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 1997 | Pubmed ID: 9315905
Adult mammalian forebrain ependymal and subependymal cells demonstrate proliferative potential, but only subependymal cells have neural stem cell characteristics.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 1999 | Pubmed ID: 10341247
Role of neural precursor cells in promoting repair following stroke.
Acta pharmacologica Sinica Jan, 2013 | Pubmed ID: 23064725
Notch signaling imparts and preserves neural stem characteristics in the adult brain.
Stem cells and development May, 2013 | Pubmed ID: 23259928
A hydrogel composite system for sustained epi-cortical delivery of Cyclosporin A to the brain for treatment of stroke.
Journal of controlled release : official journal of the Controlled Release Society Mar, 2013 | Pubmed ID: 23306024
Effectiveness of micron-sized superparamagnetic iron oxide particles as markers for detection of migration of bone marrow-derived mesenchymal stromal cells in a stroke model.
Journal of magnetic resonance imaging : JMRI Jun, 2013 | Pubmed ID: 23712844
Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke.
Journal of controlled release : official journal of the Controlled Release Society Nov, 2013 | Pubmed ID: 23933523
Neural stem and progenitor cells in the aged subependyma are activated by the young niche.
Neurobiology of aging Jul, 2014 | Pubmed ID: 24559648
Prosurvival factors derived from the embryonic brain promote adult neural stem cell survival.
Stem cells and development Oct, 2014 | Pubmed ID: 24866786
Primitive neural stem cells in the adult mammalian brain give rise to GFAP-expressing neural stem cells.
Stem cell reports Jun, 2014 | Pubmed ID: 24936468
Cyclosporin A enhances neural precursor cell survival in mice through a calcineurin-independent pathway.
Disease models & mechanisms Aug, 2014 | Pubmed ID: 25056698
Biphasic monopolar electrical stimulation induces rapid and directed galvanotaxis in adult subependymal neural precursors.
Stem cell research & therapy Apr, 2015 | Pubmed ID: 25888848
A Hyaluronan-Based Injectable Hydrogel Improves the Survival and Integration of Stem Cell Progeny following Transplantation.
Stem cell reports Jun, 2015 | Pubmed ID: 25981414
Circumventing the blood-brain barrier: Local delivery of cyclosporin A stimulates stem cells in stroke-injured rat brain.
Journal of controlled release : official journal of the Controlled Release Society Oct, 2015 | Pubmed ID: 26226344
Activating Endogenous Neural Precursor Cells Using Metformin Leads to Neural Repair and Functional Recovery in a Model of Childhood Brain Injury.
Stem cell reports Aug, 2015 | Pubmed ID: 26235894
Assessing cognitive function following medial prefrontal stroke in the rat.
Behavioural brain research Nov, 2015 | Pubmed ID: 26254877
Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke.
Cell stem cell Nov, 2015 | Pubmed ID: 26456685
Cyclosporin A enhances neurogenesis in the dentate gyrus of the hippocampus.
Stem cell research Jan, 2016 | Pubmed ID: 26720914
Enriched rehabilitation promotes motor recovery in rats exposed to neonatal hypoxia-ischemia.
Behavioural brain research May, 2016 | Pubmed ID: 26876139
Myelin Basic Protein Regulates Primitive and Definitive Neural Stem Cell Proliferation from the Adult Spinal Cord.
Stem cells (Dayton, Ohio) 02, 2017 | Pubmed ID: 27573615
Response to: Where do you come from and what are you going to become, reactive astrocyte?
Stem cell investigation , 2016 | Pubmed ID: 27582184
Stem cells in the adult CNS revealed: examining their regulation by myelin basic protein.
Neural regeneration research Dec, 2016 | Pubmed ID: 28197181
Building a central nervous system: The neural stem cell lineage revealed.
Neurogenesis (Austin, Tex.) , 2017 | Pubmed ID: 28516107
Environmental Factors That Influence Stem Cell Migration: An "Electric Field".
Stem cells international , 2017 | Pubmed ID: 28588621
In Vitro Maturation of Human iPSC-Derived Neuroepithelial Cells Influences Transplant Survival in the Stroke-Injured Rat Brain.
Tissue engineering. Part A 02, 2018 | Pubmed ID: 28594288
Quiescent Oct4 Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein NSCs in the Adult Mouse Brain.
Stem cells (Dayton, Ohio) 09, 2017 | Pubmed ID: 28733998
Home sweet home: the neural stem cell niche throughout development and after injury.
Cell and tissue research 01, 2018 | Pubmed ID: 28776186
Abstracts and Workshops 7th National Spinal Cord Injury Conference November 9 - 11, 2017 Fallsview Casino Resort Niagara Falls, Ontario, Canada.
The journal of spinal cord medicine Nov, 2017 | Pubmed ID: 29034821
Calcium influx differentially regulates migration velocity and directedness in response to electric field application.
Experimental cell research Jul, 2018 | Pubmed ID: 29729231
Cyclosporin A-Mediated Activation of Endogenous Neural Precursor Cells Promotes Cognitive Recovery in a Mouse Model of Stroke.
Frontiers in aging neuroscience , 2018 | Pubmed ID: 29740308
Neural stem cell heterogeneity in the mammalian forebrain.
Progress in neurobiology Jun, 2018 | Pubmed ID: 29902499
Skin-derived precursor cells undergo substrate-dependent galvanotaxis that can be modified by neighbouring cells.
Stem cell research Aug, 2018 | Pubmed ID: 30059907
Initial cell maturity changes following transplantation in a hyaluronan-based hydrogel and impacts therapeutic success in the stroke-injured rodent brain.
Biomaterials Feb, 2019 | Pubmed ID: 30468998
Dual embryonic origin of the mammalian enteric nervous system.
Developmental biology Jan, 2019 | Pubmed ID: 30472119
Local Delivery of Brain-Derived Neurotrophic Factor Enables Behavioral Recovery and Tissue Repair in Stroke-Injured Rats.
Tissue engineering. Part A Aug, 2019 | Pubmed ID: 30612516
Transplantation of Directly Reprogrammed Human Neural Precursor Cells Following Stroke Promotes Synaptogenesis and Functional Recovery.
Translational stroke research Feb, 2020 | Pubmed ID: 30747366
Examining the fundamental biology of a novel population of directly reprogrammed human neural precursor cells.
Stem cell research & therapy Jun, 2019 | Pubmed ID: 31196173
The optoelectronic microrobot: A versatile toolbox for micromanipulation.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2019 | Pubmed ID: 31289234
A 3D Printed Device for Low Cost Neural Stimulation in Mice.
Frontiers in neuroscience , 2019 | Pubmed ID: 31417347
Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke.
Science advances Sep, 2019 | Pubmed ID: 31535024
Cranial irradiation in juvenile mice leads to early and sustained defects in the stem and progenitor cell pools and late cognitive impairments.
Brain research Jan, 2020 | Pubmed ID: 31715143
Charge-Balanced Electrical Stimulation Can Modulate Neural Precursor Cell Migration in the Presence of Endogenous Electric Fields in Mouse Brains.
eNeuro , 2019 | Pubmed ID: 31772032
Lineage tracing reveals the hierarchical relationship between neural stem cell populations in the mouse forebrain.
Scientific reports Nov, 2019 | Pubmed ID: 31776378
Injectable hydrogel enables local and sustained co-delivery to the brain: Two clinically approved biomolecules, cyclosporine and erythropoietin, accelerate functional recovery in rat model of stroke.
Biomaterials Mar, 2020 | Pubmed ID: 31981761
The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury.
Stem cells translational medicine Dec, 2020 | Pubmed ID: 32691994
Electric Field Application Regulates Neural Precursor Cell Behavior in the Adult Mammalian Forebrain.
eNeuro , 2020 | Pubmed ID: 32719101
Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin.
Nature medicine Aug, 2020 | Pubmed ID: 32719487
Stem cell heterogeneity and regenerative competence: the enormous potential of rare cells.
Neural regeneration research Feb, 2021 | Pubmed ID: 32859777
Constraint-induced movement therapy promotes motor recovery after neonatal stroke in the absence of neural precursor activation.
The European journal of neuroscience Feb, 2021 | Pubmed ID: 33010080
Niche-dependent inhibition of neural stem cell proliferation and oligodendrogenesis is mediated by the presence of myelin basic protein.
Stem cells (Dayton, Ohio) Jun, 2021 | Pubmed ID: 33529418
Metformin pretreatment rescues olfactory memory associated with subependymal zone neurogenesis in a juvenile model of cranial irradiation.
Cell reports. Medicine Apr, 2021 | Pubmed ID: 33948569
Transplantation of Human Cortically-Specified Neuroepithelial Progenitor Cells Leads to Improved Functional Outcomes in a Mouse Model of Stroke.
Frontiers in cellular neuroscience , 2021 | Pubmed ID: 33994947
Metformin effects on brain development following cranial irradiation in a mouse model.
Neuro-oncology Sep, 2021 | Pubmed ID: 34042964
Novel Electrode Designs for Neurostimulation in Regenerative Medicine: Activation of Stem Cells.
Bioelectricity Dec, 2020 | Pubmed ID: 34471854
Substrate-Dependent Galvanotaxis of Directly Reprogrammed Human Neural Precursor Cells.
Bioelectricity Sep, 2020 | Pubmed ID: 34476355
Subacute metformin treatment reduces inflammation and improves functional outcome following neonatal hypoxia ischemia.
Brain, behavior, & immunity - health Aug, 2020 | Pubmed ID: 34589876
Editorial: Regulation of Cellular Reprogramming for Post-stroke Tissue Regeneration: Bridging a Gap Between Basic Research and Clinical Application.
Frontiers in cell and developmental biology , 2021 | Pubmed ID: 34970549
Regulating Endogenous Neural Stem Cell Activation to Promote Spinal Cord Injury Repair.
Cells Mar, 2022 | Pubmed ID: 35269466
Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke.
Journal of neuroinflammation Jun, 2022 | Pubmed ID: 35705953
Facile Fabrication of Injectable Alginate and Poly(3,4-ethylenedioxythiophene)-Based Soft Electrodes toward the Goal of Neuro-Regenerative Applications.
Advanced healthcare materials Dec, 2022 | Pubmed ID: 36177684
Tunable Surface Charge Enables the Electrostatic Adsorption-Controlled Release of Neuroprotective Peptides from a Hydrogel-Nanoparticle Drug Delivery System.
ACS applied materials & interfaces Jan, 2023 | Pubmed ID: 36520607
Bio-inspired conductive adhesive based on calcium-free alginate hydrogels for bioelectronic interfaces.
Biomedical materials (Bristol, England) Dec, 2022 | Pubmed ID: 36537718
A novel ex vivo assay to define charge-balanced electrical stimulation parameters for neural precursor cell activation in vivo.
Brain research Apr, 2023 | Pubmed ID: 36702184
Metformin Improves Functional Outcomes, Activates Neural Precursor Cells, and Modulates Microglia in a Sex-Dependent Manner After Spinal Cord Injury.
Stem cells translational medicine Jun, 2023 | Pubmed ID: 37209417
Fate Specification of GFAP-Negative Primitive Neural Stem Cells and Their Progeny at Clonal Resolution.
Stem cells and development Oct, 2023 | Pubmed ID: 37551982
Cryogel-based neurostimulation electrodes to activate endogenous neural precursor cells.
Acta biomaterialia Nov, 2023 | Pubmed ID: 37683963
Metformin treatment reduces inflammation, dysmyelination and disease severity in a mouse model of multiple sclerosis, experimental autoimmune encephalomyelitis.
Brain research Jan, 2024 | Pubmed ID: 37890574
Inhibition of Apoptosis in a Model of Ischemic Stroke Leads to Enhanced Cell Survival, Endogenous Neural Precursor Cell Activation and Improved Functional Outcomes.
International journal of molecular sciences Feb, 2024 | Pubmed ID: 38339065
Ectopic Expression of Neurod1 Is Sufficient for Functional Recovery following a Sensory-Motor Cortical Stroke.
Biomedicines Mar, 2024 | Pubmed ID: 38540276
Primitive and Definitive Neural Precursor Cells Are Present in Human Cerebral Organoids.
International journal of molecular sciences Jun, 2024 | Pubmed ID: 38928255
Glia-to-neuron reprogramming to the rescue?
Neural regeneration research May, 2025 | Pubmed ID: 39075900
Electrical Stimulation for Stem Cell-Based Neural Repair: Zapping the Field to Action.
eNeuro Sep, 2024 | Pubmed ID: 39256040
Redesigned chondroitinase ABC degrades inhibitory chondroitin sulfate proteoglycans in vitro and in vivo in the stroke-injured rat brain.
Biomaterials Mar, 2025 | Pubmed ID: 39260032
Biodegradable stimulating electrodes for resident neural stem cell activation in vivo.
Biomaterials Nov, 2024 | Pubmed ID: 39541841
Microglia in the spinal cord stem cell niche regulate neural precursor cell proliferation via soluble CD40 in response to myelin basic protein.
Stem cells (Dayton, Ohio) Nov, 2024 | Pubmed ID: 39549301
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