Cindi M. Morshead

Department of Surgery, University of Toronto

Research Area

Neuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title	2012
Publication title	2018
Publication title	2024

Other Publications

Article	Year
Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations. Nature medicine\| PubMed ID: 11875498	2002
The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells. The European journal of neuroscience\| PubMed ID: 12859339	2003
Distinct populations of forebrain neural stem and progenitor cells can be isolated using side-population analysis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14627655	2003
Disguising adult neural stem cells. Current opinion in neurobiology\| PubMed ID: 15018948	2004
Adult neural stem cells: attempting to solve the identity crisis. Developmental neuroscience\| PubMed ID: 15711053	2004
Incorporation of protein-eluting microspheres into biodegradable nerve guidance channels for controlled release. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 16325953	2006
Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16571744	2006
Exploiting the properties of adult stem cells for the treatment of disease. Current opinion in molecular therapeutics\| PubMed ID: 16955696	2006
Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells. The Journal of cell biology\| PubMed ID: 17030986	2006
True monolayer cell culture in a confined 3D microenvironment enables lineage informatics. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 17066473	2006
Extramedullary chitosan channels promote survival of transplanted neural stem and progenitor cells and create a tissue bridge after complete spinal cord transection. Tissue engineering. Part A\| PubMed ID: 18419246	2008
Delayed implantation of intramedullary chitosan channels containing nerve grafts promotes extensive axonal regeneration after spinal cord injury. Neurosurgery\| PubMed ID: 18728578	2008
Don't look: growing clonal versus nonclonal neural stem cell colonies. Stem cells (Dayton, Ohio)\| PubMed ID: 18757294	2008
Neurogenic potential of isolated precursor cells from early post-gastrula somitic tissue. Stem cells and development\| PubMed ID: 19326969	2009
Cyclosporin A has direct effects on adult neural precursor cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20181586	2010
Potential and pitfalls of stem cell therapy in old age. Disease models & mechanisms\| PubMed ID: 20504968	2010
Endogenous radial glial cells support regenerating axons after spinal cord transection. Neuroreport\| PubMed ID: 20671580	2010
Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury. Experimental neurology\| PubMed ID: 20685361	2011
Transport of epidermal growth factor in the stroke-injured brain. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21035512	2011
Wnt signaling regulates symmetry of division of neural stem cells in the adult brain and in response to injury. Stem cells (Dayton, Ohio)\| PubMed ID: 21425415	2011
Adult stem cells and bioengineering strategies for the treatment of cerebral ischemic stroke. Current stem cell research & therapy\| PubMed ID: 21476981	2011
Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain. Biomaterials\| PubMed ID: 21550655	2011
Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels. Nature materials\| PubMed ID: 21874004	2011
Adult subependymal neural precursors, but not differentiated cells, undergo rapid cathodal migration in the presence of direct current electric fields. PloS one\| PubMed ID: 21909360	2011
Hydrogel delivery of erythropoietin to the brain for endogenous stem cell stimulation after stroke injury. Biomaterials\| PubMed ID: 22217804	2012
The Effect of Growth Factors and Soluble Nogo66 Receptor Protein on Transplanted Neural Stem/Progenitor Survival and Axonal Regeneration after Complete Transection of Rat Spinal Cord. Cell transplantation\| PubMed ID: 22236767	2012
Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9315905	1997
Adult mammalian forebrain ependymal and subependymal cells demonstrate proliferative potential, but only subependymal cells have neural stem cell characteristics. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 10341247	1999
Role of neural precursor cells in promoting repair following stroke. Acta pharmacologica Sinica\| PubMed ID: 23064725	2013
Notch signaling imparts and preserves neural stem characteristics in the adult brain. Stem cells and development\| PubMed ID: 23259928	2013
A hydrogel composite system for sustained epi-cortical delivery of Cyclosporin A to the brain for treatment of stroke. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 23306024	2013
Effectiveness of micron-sized superparamagnetic iron oxide particles as markers for detection of migration of bone marrow-derived mesenchymal stromal cells in a stroke model. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 23712844	2013
Bioengineered sequential growth factor delivery stimulates brain tissue regeneration after stroke. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 23933523	2013
Neural stem and progenitor cells in the aged subependyma are activated by the young niche. Neurobiology of aging\| PubMed ID: 24559648	2014
Prosurvival factors derived from the embryonic brain promote adult neural stem cell survival. Stem cells and development\| PubMed ID: 24866786	2014
Primitive neural stem cells in the adult mammalian brain give rise to GFAP-expressing neural stem cells. Stem cell reports\| PubMed ID: 24936468	2014
Cyclosporin A enhances neural precursor cell survival in mice through a calcineurin-independent pathway. Disease models & mechanisms\| PubMed ID: 25056698	2014
Biphasic monopolar electrical stimulation induces rapid and directed galvanotaxis in adult subependymal neural precursors. Stem cell research & therapy\| PubMed ID: 25888848	2015
A Hyaluronan-Based Injectable Hydrogel Improves the Survival and Integration of Stem Cell Progeny following Transplantation. Stem cell reports\| PubMed ID: 25981414	2015
Circumventing the blood-brain barrier: Local delivery of cyclosporin A stimulates stem cells in stroke-injured rat brain. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26226344	2015
Activating Endogenous Neural Precursor Cells Using Metformin Leads to Neural Repair and Functional Recovery in a Model of Childhood Brain Injury. Stem cell reports\| PubMed ID: 26235894	2015
Assessing cognitive function following medial prefrontal stroke in the rat. Behavioural brain research\| PubMed ID: 26254877	2015
Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke. Cell stem cell\| PubMed ID: 26456685	2015
Cyclosporin A enhances neurogenesis in the dentate gyrus of the hippocampus. Stem cell research\| PubMed ID: 26720914	2016
Enriched rehabilitation promotes motor recovery in rats exposed to neonatal hypoxia-ischemia. Behavioural brain research\| PubMed ID: 26876139	2016
Myelin Basic Protein Regulates Primitive and Definitive Neural Stem Cell Proliferation from the Adult Spinal Cord. Stem cells (Dayton, Ohio)\| PubMed ID: 27573615	2017
Response to: Where do you come from and what are you going to become, reactive astrocyte? Stem cell investigation\| PubMed ID: 27582184	2016
Stem cells in the adult CNS revealed: examining their regulation by myelin basic protein. Neural regeneration research\| PubMed ID: 28197181	2016
Building a central nervous system: The neural stem cell lineage revealed. Neurogenesis (Austin, Tex.)\| PubMed ID: 28516107	2017
Environmental Factors That Influence Stem Cell Migration: An "Electric Field". Stem cells international\| PubMed ID: 28588621	2017
In Vitro Maturation of Human iPSC-Derived Neuroepithelial Cells Influences Transplant Survival in the Stroke-Injured Rat Brain. Tissue engineering. Part A\| PubMed ID: 28594288	2018
Quiescent Oct4 Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein NSCs in the Adult Mouse Brain. Stem cells (Dayton, Ohio)\| PubMed ID: 28733998	2017
Home sweet home: the neural stem cell niche throughout development and after injury. Cell and tissue research\| PubMed ID: 28776186	2018
Abstracts and Workshops 7th National Spinal Cord Injury Conference November 9 - 11, 2017 Fallsview Casino Resort Niagara Falls, Ontario, Canada. The journal of spinal cord medicine\| PubMed ID: 29034821	2017
Calcium influx differentially regulates migration velocity and directedness in response to electric field application. Experimental cell research\| PubMed ID: 29729231	2018
Cyclosporin A-Mediated Activation of Endogenous Neural Precursor Cells Promotes Cognitive Recovery in a Mouse Model of Stroke. Frontiers in aging neuroscience\| PubMed ID: 29740308	2018
Neural stem cell heterogeneity in the mammalian forebrain. Progress in neurobiology\| PubMed ID: 29902499	2018
Skin-derived precursor cells undergo substrate-dependent galvanotaxis that can be modified by neighbouring cells. Stem cell research\| PubMed ID: 30059907	2018
Initial cell maturity changes following transplantation in a hyaluronan-based hydrogel and impacts therapeutic success in the stroke-injured rodent brain. Biomaterials\| PubMed ID: 30468998	2019
Dual embryonic origin of the mammalian enteric nervous system. Developmental biology\| PubMed ID: 30472119	2019
Local Delivery of Brain-Derived Neurotrophic Factor Enables Behavioral Recovery and Tissue Repair in Stroke-Injured Rats. Tissue engineering. Part A\| PubMed ID: 30612516	2019
Transplantation of Directly Reprogrammed Human Neural Precursor Cells Following Stroke Promotes Synaptogenesis and Functional Recovery. Translational stroke research\| PubMed ID: 30747366	2020
Examining the fundamental biology of a novel population of directly reprogrammed human neural precursor cells. Stem cell research & therapy\| PubMed ID: 31196173	2019
The optoelectronic microrobot: A versatile toolbox for micromanipulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31289234	2019
A 3D Printed Device for Low Cost Neural Stimulation in Mice. Frontiers in neuroscience\| PubMed ID: 31417347	2019
Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke. Science advances\| PubMed ID: 31535024	2019
Cranial irradiation in juvenile mice leads to early and sustained defects in the stem and progenitor cell pools and late cognitive impairments. Brain research\| PubMed ID: 31715143	2020
Charge-Balanced Electrical Stimulation Can Modulate Neural Precursor Cell Migration in the Presence of Endogenous Electric Fields in Mouse Brains. eNeuro\| PubMed ID: 31772032	2019
Lineage tracing reveals the hierarchical relationship between neural stem cell populations in the mouse forebrain. Scientific reports\| PubMed ID: 31776378	2019
Injectable hydrogel enables local and sustained co-delivery to the brain: Two clinically approved biomolecules, cyclosporine and erythropoietin, accelerate functional recovery in rat model o... Biomaterials\| PubMed ID: 31981761	2020
The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury. Stem cells translational medicine\| PubMed ID: 32691994	2020
Electric Field Application Regulates Neural Precursor Cell Behavior in the Adult Mammalian Forebrain. eNeuro\| PubMed ID: 32719101	2020
Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin. Nature medicine\| PubMed ID: 32719487	2020
Stem cell heterogeneity and regenerative competence: the enormous potential of rare cells. Neural regeneration research\| PubMed ID: 32859777	2021
Constraint-induced movement therapy promotes motor recovery after neonatal stroke in the absence of neural precursor activation. The European journal of neuroscience\| PubMed ID: 33010080	2021
Niche-dependent inhibition of neural stem cell proliferation and oligodendrogenesis is mediated by the presence of myelin basic protein. Stem cells (Dayton, Ohio)\| PubMed ID: 33529418	2021
Metformin pretreatment rescues olfactory memory associated with subependymal zone neurogenesis in a juvenile model of cranial irradiation. Cell reports. Medicine\| PubMed ID: 33948569	2021
Transplantation of Human Cortically-Specified Neuroepithelial Progenitor Cells Leads to Improved Functional Outcomes in a Mouse Model of Stroke. Frontiers in cellular neuroscience\| PubMed ID: 33994947	2021
Metformin effects on brain development following cranial irradiation in a mouse model. Neuro-oncology\| PubMed ID: 34042964	2021
Novel Electrode Designs for Neurostimulation in Regenerative Medicine: Activation of Stem Cells. Bioelectricity\| PubMed ID: 34471854	2020
Substrate-Dependent Galvanotaxis of Directly Reprogrammed Human Neural Precursor Cells. Bioelectricity\| PubMed ID: 34476355	2020
Subacute metformin treatment reduces inflammation and improves functional outcome following neonatal hypoxia ischemia. Brain, behavior, & immunity - health\| PubMed ID: 34589876	2020
Editorial: Regulation of Cellular Reprogramming for Post-stroke Tissue Regeneration: Bridging a Gap Between Basic Research and Clinical Application. Frontiers in cell and developmental biology\| PubMed ID: 34970549	2021
Regulating Endogenous Neural Stem Cell Activation to Promote Spinal Cord Injury Repair. Cells\| PubMed ID: 35269466	2022
Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke. Journal of neuroinflammation\| PubMed ID: 35705953	2022
Facile Fabrication of Injectable Alginate and Poly(3,4-ethylenedioxythiophene)-Based Soft Electrodes toward the Goal of Neuro-Regenerative Applications. Advanced healthcare materials\| PubMed ID: 36177684	2022
Tunable Surface Charge Enables the Electrostatic Adsorption-Controlled Release of Neuroprotective Peptides from a Hydrogel-Nanoparticle Drug Delivery System. ACS applied materials & interfaces\| PubMed ID: 36520607	2023
Bio-inspired conductive adhesive based on calcium-free alginate hydrogels for bioelectronic interfaces. Biomedical materials (Bristol, England)\| PubMed ID: 36537718	2022
A novel ex vivo assay to define charge-balanced electrical stimulation parameters for neural precursor cell activation in vivo. Brain research\| PubMed ID: 36702184	2023
Metformin Improves Functional Outcomes, Activates Neural Precursor Cells, and Modulates Microglia in a Sex-Dependent Manner After Spinal Cord Injury. Stem cells translational medicine\| PubMed ID: 37209417	2023
Fate Specification of GFAP-Negative Primitive Neural Stem Cells and Their Progeny at Clonal Resolution. Stem cells and development\| PubMed ID: 37551982	2023
Cryogel-based neurostimulation electrodes to activate endogenous neural precursor cells. Acta biomaterialia\| PubMed ID: 37683963	2023
Metformin treatment reduces inflammation, dysmyelination and disease severity in a mouse model of multiple sclerosis, experimental autoimmune encephalomyelitis. Brain research\| PubMed ID: 37890574	2024
Inhibition of Apoptosis in a Model of Ischemic Stroke Leads to Enhanced Cell Survival, Endogenous Neural Precursor Cell Activation and Improved Functional Outcomes. International journal of molecular sciences\| PubMed ID: 38339065	2024
Ectopic Expression of Neurod1 Is Sufficient for Functional Recovery following a Sensory-Motor Cortical Stroke. Biomedicines\| PubMed ID: 38540276	2024
Primitive and Definitive Neural Precursor Cells Are Present in Human Cerebral Organoids. International journal of molecular sciences\| PubMed ID: 38928255	2024
Glia-to-neuron reprogramming to the rescue? Neural regeneration research\| PubMed ID: 39075900	2025
Electrical Stimulation for Stem Cell-Based Neural Repair: Zapping the Field to Action. eNeuro\| PubMed ID: 39256040	2024
Redesigned chondroitinase ABC degrades inhibitory chondroitin sulfate proteoglycans in vitro and in vivo in the stroke-injured rat brain. Biomaterials\| PubMed ID: 39260032	2025
Biodegradable stimulating electrodes for resident neural stem cell activation in vivo. Biomaterials\| PubMed ID: 39541841	2024
Microglia in the spinal cord stem cell niche regulate neural precursor cell proliferation via soluble CD40 in response to myelin basic protein. Stem cells (Dayton, Ohio)\| PubMed ID: 39549301	2024