Department of Neuroscience
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Traffic at the intersection of neurotrophic factor signaling and neurodegeneration.
Trends in neurosciences Feb, 2003 | Pubmed ID: 12536130
NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals.
Neuron Jul, 2003 | Pubmed ID: 12848933
Trafficking the NGF signal: implications for normal and degenerating neurons.
Progress in brain research , 2004 | Pubmed ID: 14699953
Signaling endosome hypothesis: A cellular mechanism for long distance communication.
Journal of neurobiology Feb, 2004 | Pubmed ID: 14704953
Going the distance, or not, with neurotrophin signals.
Cell Jul, 2004 | Pubmed ID: 15260984
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2004 | Pubmed ID: 15371516
Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation.
Brain research Oct, 2004 | Pubmed ID: 15374749
An AUPN/ANA survey of department leader opinions on the health of US academic neurology.
Neurology Oct, 2004 | Pubmed ID: 15505148
Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.
The Journal of comparative neurology Dec, 2004 | Pubmed ID: 15515178
Long-distance retrograde neurotrophic signaling.
Current opinion in neurobiology Feb, 2005 | Pubmed ID: 15721743
Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.
Mammalian genome : official journal of the International Mammalian Genome Society Feb, 2005 | Pubmed ID: 15859352
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2006 | Pubmed ID: 16801538
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Neuron Jul, 2006 | Pubmed ID: 16815330
Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2007 | Pubmed ID: 17287360
Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.
The Journal of comparative neurology Oct, 2007 | Pubmed ID: 17663443
One at a time, live tracking of NGF axonal transport using quantum dots.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2007 | Pubmed ID: 17698956
A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway.
Traffic (Copenhagen, Denmark) Nov, 2007 | Pubmed ID: 17822405
Using mouse models to explore genotype-phenotype relationship in Down syndrome.
Mental retardation and developmental disabilities research reviews , 2007 | Pubmed ID: 17910089
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.
Traffic (Copenhagen, Denmark) Feb, 2008 | Pubmed ID: 18034774
Sleep and EEG features in genetic models of Down syndrome.
Neurobiology of disease Apr, 2008 | Pubmed ID: 18282758
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome.
The Journal of comparative neurology May, 2008 | Pubmed ID: 18306326
Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.
Critical reviews in toxicology , 2008 | Pubmed ID: 18726789
Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2008 | Pubmed ID: 18768694
The coming of age of axonal neurotrophin signaling endosomes.
Journal of proteomics Feb, 2009 | Pubmed ID: 19028611
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome.
The Journal of comparative neurology Feb, 2009 | Pubmed ID: 19034952
Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation.
Neurobiology of disease Apr, 2009 | Pubmed ID: 19167498
Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks.
The Journal of comparative neurology May, 2009 | Pubmed ID: 19296534
The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2009 | Pubmed ID: 19420260
The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome.
Genetics in medicine : official journal of the American College of Medical Genetics Sep, 2009 | Pubmed ID: 19636252
Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice.
Mammalian genome : official journal of the International Mammalian Genome Society Jun, 2010 | Pubmed ID: 20512340
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Neuron Sep, 2010 | Pubmed ID: 20826309
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.
Brain research Dec, 2010 | Pubmed ID: 20932954
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease.
Journal of neurochemistry May, 2011 | Pubmed ID: 21388375
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.
Neurobiology of disease Aug, 2011 | Pubmed ID: 21527343
Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator.
Organic letters Sep, 2011 | Pubmed ID: 21812392
Mouse models for Down syndrome-associated developmental cognitive disabilities.
Developmental neuroscience , 2011 | Pubmed ID: 21865664
Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome.
Neurobiology of disease Feb, 2012 | Pubmed ID: 22062771
Genetic analysis of Down syndrome facilitated by mouse chromosome engineering.
Bioengineered bugs Jan, 2012 | Pubmed ID: 22126738
Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome.
Current opinion in neurobiology Oct, 2012 | Pubmed ID: 22658745
Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2012 | Pubmed ID: 22764230
Potential use of γ-secretase modulators in the treatment of Alzheimer disease.
Archives of neurology Oct, 2012 | Pubmed ID: 22801784
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Nature medicine Apr, 2013 | Pubmed ID: 23524343
Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies.
Chemistry (Weinheim an der Bergstrasse, Germany) May, 2013 | Pubmed ID: 23526661
Aging and intellectual disability: Insights from mouse models of down syndrome.
Developmental disabilities research reviews Aug, 2013 | Pubmed ID: 23949828
Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.
Human molecular genetics Feb, 2014 | Pubmed ID: 24041763
The challenge of connecting the dots in the B.R.a.I.N.
Neuron Oct, 2013 | Pubmed ID: 24139032
Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species.
Biochemistry Feb, 2014 | Pubmed ID: 24401146
Sarah H. Shahmoradian1,
Mauricio R. Galiano2,
Chengbiao Wu3,
Shurui Chen4,
Matthew N. Rasband2,
William C. Mobley3,
Wah Chiu4
1Department of Molecular Physiology and Biophysics, Baylor College of Medicine,
2Department of Neuroscience, Baylor College of Medicine,
3Department of Neuroscience, University of California at San Diego,
4National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
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