We express gratitude to the patients and medical staff of the Second Hospital of Jiaxing for their support and cooperation during the research process.

This study (Approval No. JXEY-2020SW038) was approved by the Medical Ethics Committee of the Second Hospital of Jiaxing, with all participants providing informed consent. It aimed to assess the feasibility and effectiveness of a protocol through a randomized, single-blind, controlled trial. Between January and December 2021, 60 stroke patients admitted to the Second Hospital of Jiaxing were enrolled.
NOTE: Inclusion criteria comprised: 1) confirmed diagnosis of cerebral infarction or hemorrhage via computed tomography (CT) or magnetic resonance imaging (MRI), 2) first-onset and unilateral lesion with a disease duration of 2 weeks to 3 months and a stable condition, 3) age 25-75 years, 4) absence of hemianopsia or unilateral spatial neglect, as well as no visual or auditory deficits, 5) conscious, compliant, and able to participate in rehabilitation treatment, 6) clear unilateral upper limb dysfunction with a modified Ashworth scale (MAS) grade &#8804; 216. Exclusion criteria included: 1) previous craniocerebral injury or other intracranial diseases, 2) severe myocardial infarction, angina pectoris, liver, kidney, lung, or other important organ diseases, malignant tumors, etc., 3) previous history of psychiatric disorders and epilepsy, 4) severe pain, numbness, or other sensory deficits on the hemiplegic side of the limbs, 5) significant limitation of movement in the bilateral upper limbs.
1. Study design
<ol>
	<li>Randomly divide patients (n = 60) who met the specified criteria into two groups: an experimental group (n = 30) and a control group (n = 30).</li>
	<li>Have a skilled occupational therapist complete the following functional assessments, who was unaware of the group assignments before and after a 6-week treatment period.
	<ol>
		<li>Motor evoked potential (MEP):
		<ol>
			<li>Elicit MEPs in patients using a magnetic stimulation therapy system following the guidelines established by Groppa et al.17.</li>
			<li>During the test, position the patient in front of the device in a stable and comfortable manner and place the recording electrode pads on the abductor pollicis brevis and wrist joint osseous process.</li>
			<li>Then, center the magnetic stimulation coil above the motor cortex on the injured side of the brain, with the coil handle positioned at a 45&#176; angle to the sagittal plane.</li>
			<li>Carry out stimulation of the motor cortex area 10 times at 100% intensity and record the presence or absence of motor-evoked potentials, along with their latency and amplitude. 
			NOTE: Due to the inability to detect motor evoked potentials in all patients, a thorough comparison and analysis of the latency and amplitude of the evoked potentials between the two patient groups was not feasible. Therefore, the study aimed to determine the presence or absence of MEPs and compare the percentage of detectable MEPs between two groups of patients. A higher percentage of detectable MEPs indicates a greater potential for enhancing corticospinal pathways in stroke patients.</li>
		</ol>
		</li>
		<li>Perform functional test for the hemiplegic upper extremity-Hong Kong (FTHUE-HK).
		<ol>
			<li>Utilize the scale to assess the patient&#39;s upper limb functionality, which includes 12 tasks, such as placing the hand on the knee and wringing a rag. 
			NOTE: Each task must be completed within 3 min and can only be attempted up to 3 times. The scale comprises 7 levels, with higher levels indicating better upper limb functionality18.</li>
		</ol>
		</li>
		<li>Use the Fugl-Meyer Assessment Upper Extremity Scale (FMA-UE).
		<ol>
			<li>Utilize this scale to evaluate the motor function of the shoulder, elbow, forearm, wrist, and hand. 
			NOTE: A score of 0 indicates inability to perform the specified movement, a score of 1 indicates partial completion, and a score of 2 indicates full completion. The scale has a maximum score of 66 points, with higher scores indicating better upper limb motor function19.</li>
		</ol>
		</li>
		<li>Calculate the Modified Barthel index (MBI).
		<ol>
			<li>Utilize this scale to assess the patient&#39;s performance in activities of daily living. 
			NOTE: The scale consists of 10 items, including eating, dressing, bathing, etc., with a maximum score of 100 points. A higher score indicates greater independence in the patient&#39;s daily life20.</li>
		</ol>
		</li>
	</ol>
	</li>
	<li>Ensure that all patients are prescribed conventional medications, including anti-hypertensives, anti-diabetics, lipid regulators, etc., tailored to their individual conditions. 
	NOTE: The medication selection for stroke patients is based on their unique circumstances and may differ from one patient to another.</li>
	<li>Confirm that all patients received routine physical therapy, occupational therapy for the forearm and hand, and activities of daily living training for 6 weeks.</li>
	<li>Ensure that patients in the control group received routine occupational therapy targeting upper limb function for 1 h per day for 6 weeks. 
	NOTE: The routine occupational therapy targeting upper limb function includes motor control training for the shoulder and elbow joints, roller training, hoop training, and reaching for objects training.</li>
	<li>Confirm that patients in the experimental group received routine occupational therapy targeting upper limb function for 30 min per day, in addition to dual upper limb task-oriented robotic system training for 30 min per day for 6 weeks.</li>
</ol>
2. Dual upper limb task-oriented robotic system training session
NOTE: Only the stroke patients in the experimental group received these training sessions.
<ol>
	<li>Start the robotic system equipment, turn on the system&#39;s computer screen, open the ULCOT Rehab application, and enter the main interface of the system.</li>
	<li>During the initial training session, click Register to establish a personal file for each patient, mainly including name, gender, age, case number, diagnosis, affected side, and other relevant medical contents.</li>
	<li>Click Login on the main interface of the system, select the patient who needs training from the list, and enter the interface of the training system for that patient.</li>
	<li>Assist the patient in positioning themselves in front of the robotic device, ensuring a safe and comfortable distance.</li>
	<li>Click Adjustment on the interface of the patient training system to enter the interface of equipment parameter adjustment and set the appropriate parameters for the patient. 
	NOTE: It is not necessary to set parameters for each training session. Upon logging into the patient&#39;s training system interface, the system automatically adjusts to the parameters established during the patient&#39;s previous training session. The therapist can then modify the corresponding parameters in accordance with the therapeutic goals. If no changes to the parameters are needed, the user can click Training in the training system interface to access the training program setting interface.
	<ol>
		<li>Click on + or - to increase or decrease the height of the platform in the Platform Height Adjustment module. Adjust the height of the equipment platform based on the patient&#39;s height.</li>
		<li>Click + or - to increase or decrease the tilt angle of the system&#39;s robot arm in the Arm Tilt Angle Adjustment module. Adjust the tilt angle of the robotic arm according to the patient&#39;s shoulder flexion and extension training goals (the higher the target, the greater the angle).</li>
		<li>Click + or - to increase or decrease the angle between the two robot arms in the Arm Angle Adjustment module. Adjust the angle between the robotic arms according to the patient&#39;s upper limb adduction and abduction training goals (the higher the goal, the greater the angle).</li>
	</ol>
	</li>
	<li>Click Training in the patient training system interface to enter the training program setting interface.
	<ol>
		<li>Select an appropriate training program based on the patient&#39;s upper limb functional status. When the upper limb on the hemiplegic side is unable to actively manipulate the mechanical handle through the full range of motion, opt for the assisted training program.</li>
		<li>Conversely, if the upper limb on the hemiplegic side is capable of actively manipulating the mechanical handle to complete the full range of motion, choose the resistance training program.</li>
	</ol>
	</li>
	<li>Explain and demonstrate the training methods of the selected items and inform relevant precautions to ensure that patients know how to perform the training session safely and accurately.</li>
	<li>Help the patient to fix their hands on the handles at the end of the two robotic arms (Figure 1).</li>
	<li>Conduct dual upper limb task-oriented robot system training.
	<ol>
		<li>For patients who are unable to actively manipulate the mechanical handle to achieve a full range of motion on the hemiplegic side of the upper limb, click Assistance in the training program setting interface to enter the assisted training mode interface. 
		NOTE: The therapist may select Air Flying game or Ping-Pong game for the patient in assisted training mode. It should be noted that patients may only select one game per training session.
		<ol>
			<li>Set the time to 30 min in the Training Time module, and select the level set for the patient in the Assisted Level module. 
			NOTE: This mode offers 6 levels of assistance, with level 6 involving the affected upper limb being driven by both the robot and the healthy upper limb during bilateral upper limb training. On the other hand, level 1 entails the affected upper limb participating in bilateral upper limb training directly without external force. The training session commences at level 6, and the patient can progress to the next level after achieving a full score at each level. Once the patient attains a full training score at assistance level 1, they are deemed ready for resistance mode training.</li>
			<li>Click Air Flying or Ping-Pong, then click Start to enter the game interface.</li>
			<li>Air Flying game: Instruct the patient to control a virtual airplane displayed on the computer screen by maneuvering the affected upper limb through the healthy side with the assistance of a robotic device, enabling the patient to optimize their efforts in guiding the virtual airplane along the designated flight trajectory while simultaneously capturing virtual gold coins (Figure 2).</li>
			<li>Ping-Pong game: With the assistance of the robot, instruct the patient to use the unaffected side to drive the affected side upper limb to control the virtual table tennis racket and move the racket to catch the flying ping-pong (Figure 3).</li>
		</ol>
		</li>
		<li>For patients who are able to actively manipulate the mechanical handle to achieve a full range of motion on the hemiplegic side of the upper limb, click Resistance in the training program settings interface to access the resistance training mode interface. 
		NOTE: In the resistance training mode, participants can choose from five available games: Air Flying, Ping-Pong, Bridge &#38; Road, Weight-Lifting, and Pop Matching. Only one game may be selected for each training session.
		<ol>
			<li>Set the time to 30 min in the Training Time module, and select the resistance levels of the healthy side and the affected side, respectively, in the Healthy Level and Affected Level modules. 
			NOTE: In the resistance training mode, resistance levels can be individually set for the patient&#39;s healthy and affected sides based on upper limb muscle strength. Levels range from 1 (lowest resistance) to 10 (highest resistance). The initial treatment involved the selection of Level 1 resistance, with patients permitted to progress to the subsequent level upon achieving a perfect score on each level of training.</li>
			<li>In the Healthy Side Resistance Direction and Affected Side Resistance Direction modules, select the resistance direction indicated by the system for the patient&#39;s healthy side and the affected side of the upper limb during resistance training, respectively. 
			NOTE: The direction of resistance is selected for the patient according to the purpose of the exercise, including push and pull.</li>
			<li>Select the amount of time the target needs to be held in the Holding Time module. 
			NOTE: The time is determined based on the patient&#39;s upper limb function, ranging from 1 to 10 s. The longer the time, the more challenging it becomes. If the set holding time is 10 s and the training score is perfect, the resistance level will be increased for the next session. The Air Flying and Ping-Pong games do not include this step.</li>
			<li>Click to select one of the following games: Air Flying, Ping-Pong, Bridge &#38; Road, Weight-Lifting, and Pop Matching. Click Start to enter the game interface.</li>
			<li>Air Flying game: Instruct the patient to control the virtual airplane by resisting the resistance given by the robotic arm on both the healthy and affected upper limbs, enabling the patient to optimize their efforts in guiding the virtual airplane along the designated flight trajectory while simultaneously capturing virtual gold coins.</li>
			<li>Ping-Pong game: Instruct the patient to control the virtual table tennis racket by resisting the resistance given by the robotic arm on both the healthy and affected upper limbs and move the racket to catch the flying ping-pong.</li>
			<li>Bridge &#38; Road game: Have&#160;the patient control both ends of a wooden&#160;bridge on the screen by resisting the resistance&#160;given by the robotic arm on both the healthy&#160;and affected upper limbs, move two ladder platforms of different heights, and hold them&#160;for a certain time to allow the virtual character&#160;to pass (Figure 4).</li>
			<li>Weight-Lifting game: Have&#160;the patient control the ends of a weight-lifting&#160;barbell displayed on a screen by resisting the&#160;resistance given by the robotic arm on both the healthy 
			and affected upper limbs,&#160;adjusting its position to reach a target location&#160;by varying the distance and maintaining that&#160;position for a specified duration&#160;(Figure 5).</li>
			<li>Pop Matching game:&#160;Have the patient control two virtual 
			fingers located at the left and right ends&#160;of the screen by resisting the resistance given&#160;by the robotic arm on both the healthy and&#160;affected upper limbs, select identical items from the left and right columns of pictures&#160;through the virtual fingers and maintain this position for a 
			designated duration (Figure 6). 
			NOTE: The system verifies whether the selected pictures on both sides are the same; if they are, the selected pictures are eliminated. If they do not match, the patient is prompted to re-select.</li>
		</ol>
		</li>
	</ol>
	</li>
</ol>
3. Follow-up procedure
<ol>
	<li>Utilize statistical software to analyze the assessment data collected, determining appropriate analysis methods based on the data type.</li>
	<li>Elucidate the significance of the data results and evaluate the impact of dual upper limb task-oriented robot system training on upper limb function in stroke patients.</li>
</ol>

Dual Upper Limb Robotic Training in Stroke Rehabilitation

<ol>
	<li>Feigin, V. L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=World+Stroke+Organization+(WSO):+Global+stroke+fact+sheet+2022.">World Stroke Organization (WSO): Global stroke fact sheet 2022.</a> Int J Stroke. 17 (1), 18-29 (2022).</li><li>Kiper, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Effects+of+immersive+virtual+reality+on+upper-extremity+stroke+rehabilitation:+A+systematic+review+with+meta-analysis.">Effects of immersive virtual reality on upper-extremity stroke rehabilitation: A systematic review with meta-analysis.</a> J Clin Med. 13 (1), 146 (2023).</li><li>Yao, Z., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cognitive+function+and+upper+limb+rehabilitation+training+post-stroke+using+a+digital+occupational+training+system.">Cognitive function and upper limb rehabilitation training post-stroke using a digital occupational training system.</a> J Vis Exp. (202), e65994 (2023).</li><li>Tang, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Bilateral+upper+limb+robot-assisted+rehabilitation+improves+upper+limb+motor+function+in+stroke+patients:+a+study+based+on+quantitative+EEG.">Bilateral upper limb robot-assisted rehabilitation improves upper limb motor function in stroke patients: a study based on quantitative EEG.</a> Eur J Med Res. 28 (1), 603 (2023).</li><li>Yang, S. -. W., Ma, S. -. R., Choi, J. -. B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Effect+of+3-dimensional+robotic+therapy+combined+with+electromyography-triggered+neuromuscular+electrical+stimulation+on+upper+limb+function+and+cerebral+cortex+activation+in+stroke+patients:+A+randomized+controlled+trial.">Effect of 3-dimensional robotic therapy combined with electromyography-triggered neuromuscular electrical stimulation on upper limb function and cerebral cortex activation in stroke patients: A randomized controlled trial.</a> Bioengineering. 11 (1), 12 (2023).</li><li>Chen, P. M., Kwong, P. W. H., Lai, C. K. Y., Ng, S. S. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Comparison+of+bilateral+and+unilateral+upper+limb+training+in+people+with+stroke:+A+systematic+review+and+meta-analysis.">Comparison of bilateral and unilateral upper limb training in people with stroke: A systematic review and meta-analysis.</a> PLoS One. 14 (5), e0216357 (2019).</li><li>Dhakate, D., Bhattad, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Study+the+effectiveness+of+bilateral+arm+training+on+upper+extremity+motor+function+and+activity+level+in+patients+with+sub-acute+stroke.">Study the effectiveness of bilateral arm training on upper extremity motor function and activity level in patients with sub-acute stroke.</a> Int J Cur Res Rev. 12 (20), 2987 (2020).</li><li>Ahn, S. Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Benefits+of+robot-assisted+upper-limb+rehabilitation+from+the+subacute+stage+after+a+stroke+of+varying+severity:+A+multicenter+randomized+controlled+trial.">Benefits of robot-assisted upper-limb rehabilitation from the subacute stage after a stroke of varying severity: A multicenter randomized controlled trial.</a> J Clin Med. 13 (3), 808 (2024).</li><li>Li, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dual-tDCS+combined+with+sensorimotor+training+promotes+upper+limb+function+in+subacute+stroke+patients:+A+randomized,+double-blinded,+sham-controlled+study.">Dual-tDCS combined with sensorimotor training promotes upper limb function in subacute stroke patients: A randomized, double-blinded, sham-controlled study.</a> CNS Neurosci Ther. 30 (4), e14530 (2023).</li><li>Yuan, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Effects+of+uni-+vs.+bilateral+upper+limb+robot-assisted+rehabilitation+on+motor+function,+activities+of+daily+living,+and+electromyography+in+hemiplegic+stroke:+A+single-blinded+three-arm+randomized+controlled+trial.">Effects of uni- vs. bilateral upper limb robot-assisted rehabilitation on motor function, activities of daily living, and electromyography in hemiplegic stroke: A single-blinded three-arm randomized controlled trial.</a> J Clin Med. 12 (8), 2950 (2023).</li><li>Song, Y. -. H., Lee, H. -. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Effect+of+immersive+virtual+reality-based+bilateral+arm+training+in+patients+with+chronic+stroke.">Effect of immersive virtual reality-based bilateral arm training in patients with chronic stroke.</a> Brain Sci. 11 (8), 1032 (2021).</li><li>Dembele, J., Triccas, L. T., Amanzonw&#233;, L. E. R., Kossi, O., Spooren, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Bilateral+versus+unilateral+upper+limb+training+in+(sub)acute+stroke:+A+systematic+and+meta-analysis.">Bilateral versus unilateral upper limb training in (sub)acute stroke: A systematic and meta-analysis.</a> S Afr J Physiother. 80 (1), 1985 (2024).</li><li>Wu, J. Y., Cheng, H., Zhang, J. Q., Bai, Z. F., Cai, S. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+modulatory+effects+of+bilateral+arm+training+(BAT)+on+the+brain+in+stroke+patients:+a+systematic+review.">The modulatory effects of bilateral arm training (BAT) on the brain in stroke patients: a systematic review.</a> Neurol Sci. 42 (2), 501-511 (2021).</li><li>Yang, X. W., Shi, X. B., Xue, X. L., Deng, Z. Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Efficacy+of+robot-assisted+training+on+rehabilitation+of+upper+limb+function+in+patients+with+stroke:+A+systematic+review+and+meta-analysis.">Efficacy of robot-assisted training on rehabilitation of upper limb function in patients with stroke: A systematic review and meta-analysis.</a> Arch Phys Med Rehabil. 104 (9), 1498-1513 (2023).</li><li>Wu, J. Y., Cheng, H., Zhang, J. Q., Yang, S. L., Cai, S. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Robot-assisted+therapy+for+upper+extremity+motor+impairment+after+stroke:+A+systematic+review+and+meta-analysis.">Robot-assisted therapy for upper extremity motor impairment after stroke: A systematic review and meta-analysis.</a> Phys Ther. 101 (4), pzab010 (2021).</li><li>Meseguer-Henarejos, A. B., S&#225;nchez-Meca, J., L&#243;pez-Pina, J. A., Carles-Hern&#225;ndez, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Inter-+and+intra-rater+reliability+of+the+Modified+Ashworth+Scale:+a+systematic+review+and+meta-analysis.">Inter- and intra-rater reliability of the Modified Ashworth Scale: a systematic review and meta-analysis.</a> Eur J Phys Rehabil Med. 54 (4), 576-590 (2018).</li><li>Groppa, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+practical+guide+to+diagnostic+transcranial+magnetic+stimulation:+report+of+an+IFCN+committee.">A practical guide to diagnostic transcranial magnetic stimulation: report of an IFCN committee.</a> Clin Neurophysiol. 123 (5), 858-882 (2012).</li><li>Fong, K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Development+of+the+Hong+Kong+version+of+the+functional+test+for+the+hemiplegic+upper+extremity+(FTHUE-HK).">Development of the Hong Kong version of the functional test for the hemiplegic upper extremity (FTHUE-HK).</a> Hong Kong J Occup Th. 14 (1), 21-29 (2004).</li><li>Hern&#225;ndez, E. D., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Intra-+and+inter-rater+reliability+of+Fugl-Meyer+Assessment+of+Upper+Extremity+in+stroke.">Intra- and inter-rater reliability of Fugl-Meyer Assessment of Upper Extremity in stroke.</a> J Rehabil Med. 51 (9), 652-659 (2019).</li><li>Ohura, T., Hase, K., Nakajima, Y., Nakayama, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Validity+and+reliability+of+a+performance+evaluation+tool+based+on+the+modified+Barthel+Index+for+stroke+patients.">Validity and reliability of a performance evaluation tool based on the modified Barthel Index for stroke patients.</a> BMC Med Res Methodol. 17 (1), 131 (2017).</li><li>Wu, J., Cheng, H., Zhang, J., Bai, Z., Cai, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+modulatory+effects+of+bilateral+arm+training+(BAT)+on+the+brain+in+stroke+patients:+a+systematic+review.">The modulatory effects of bilateral arm training (BAT) on the brain in stroke patients: a systematic review.</a> Neurol Sci. 42 (2), 501-511 (2021).</li><li>Hsu, H. Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Robotic-assisted+therapy+with+bilateral+practice+improves+task+and+motor+performance+in+the+upper+extremities+of+chronic+stroke+patients:+A+randomised+controlled+trial.">Robotic-assisted therapy with bilateral practice improves task and motor performance in the upper extremities of chronic stroke patients: A randomised controlled trial.</a> Aust Occup Ther J. 66 (5), 637-647 (2019).</li><li>Kitsos, G. H., Hubbard, I. J., Kitsos, A. R., Parsons, M. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+ipsilesional+upper+limb+can+be+affected+following+stroke.">The ipsilesional upper limb can be affected following stroke.</a> ScientificWorldJournal. 2013, 684860 (2013).</li><li>Bustr&#233;n, E. L., Sunnerhagen, K. S., Alt Murphy, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Movement+kinematics+of+the+ipsilesional+upper+extremity+in+persons+with+moderate+or+mild+stroke.">Movement kinematics of the ipsilesional upper extremity in persons with moderate or mild stroke.</a> Neurorehabil Neural Repair. 31 (4), 376-386 (2017).</li><li>da Silva, E. S. M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+effect+of+priming+on+outcomes+of+task-oriented+training+for+the+upper+extremity+in+chronic+stroke:+A+systematic+review+and+meta-analysis.">The effect of priming on outcomes of task-oriented training for the upper extremity in chronic stroke: A systematic review and meta-analysis.</a> Neurorehabil Neural Repair. 34 (6), 479-504 (2020).</li><li>Lee, C. Y., Howe, T. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Effectiveness+of+activity-based+task-oriented+training+on+upper+extremity+recovery+for+adults+with+stroke:+A+systematic+review.">Effectiveness of activity-based task-oriented training on upper extremity recovery for adults with stroke: A systematic review.</a> Am J Occup Ther. 78 (2), 7802180070 (2024).</li></ol>

The authors declare no conflicts of interest or financial disclosures in this study.

Bilateral training has been shown to normalize intercortical inhibition in stroke patients, facilitate brain functional network reorganization, and ultimately enhance upper limb function21. This study presents a program for upper limb functional training in stroke patients utilizing a dual upper limb task-oriented robotic system. The program integrates bilateral upper limb movement, task-oriented activities, and robot-assisted training to enhance the rehabilitation of upper limb function in stroke...

Stroke is one of the major causes of disability and the second leading cause of death globally1,2. Stroke patients often face various challenges, such as motor, sensory, and cognitive deficits3. Upper limb dysfunction is a common problem after stroke, characterized by muscle weakness, spasticity, and reduced motor ability of the upper limb on the hemiplegic side4. It is reported to be present in more than 70% of stroke patients, and only around 5% recover to normal, while 20% regain some upper limb capabilities5. More than half of human life requires the participation of the upper limbs6, and upper limb dysfunction after a stroke severely affects patients' activities of daily living7, significantly decreasing their quality of life8 and increasing their financial burden9. Therefore, it is particularly important to explore effective methods of upper limb functional rehabilitation.
Various clinical upper limb rehabilitation treatments, such as mirror therapy, constraint-induced movement therapy, functional electrical stimulation, and other active or passive training, are commonly utilized for stroke patients3,10. In recent years, bilateral arm training has garnered increased attention6,11,12. It has been demonstrated to enhance neural connectivity between the sensorimotor areas of both ipsilateral and contralateral hemispheres12. This type of training helps correct abnormalities in interhemispheric inhibition, facilitates reorganization of brain functional networks, and ultimately leads to improvements in upper limb function12,13. Furthermore, robot-assisted training has also been shown to assist patients in consistently executing accurate limb movements and engaging in task-specific training14. This process provides the brain with substantial feedback stimulation, ultimately boosting neuroplasticity and aiding in the restoration of upper limb function in individuals with hemiplegia14,15. There is currently limited research on strategies utilizing robot-assisted dual upper limb training for stroke patients. This study employed a dual upper limb task-oriented robotic system to combine robot-assisted training with bilateral upper limb training. The robotic device was utilized to aid stroke patients in conducting dual upper limb task-oriented training with high repetitions in a proper movement pattern. The objective of the research was to evaluate the effects of this method on the corticospinal pathway, upper-limb function, and activities of daily living in stroke survivors, with the aim of discovering innovative strategies for upper limb functional rehabilitation.

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>Dual upper limb task-oriented robotic system</td>
			<td>Auckland Tongji Rehabilitation Medical Equipment Research Center, Tongji Zhejiang College</td>
			<td>N/A</td>
			<td>The dual upper limb task-oriented robotic system can aid stroke patients in bilateral upper limb virtual game training by regulating force transmission between the healthy and affected upper limbs.</td>
		</tr>
		<tr>
			<td>Magnetic stimulation therapy system</td>
			<td>Sichuan Junjian Wanfeng Medical Equipment Co.,Ltd.</td>
			<td>http://www.jjwf-med.com</td>
			<td> 
			This system can be used to measure the Motor evoked potential (MEP)</td>
		</tr>
		<tr>
			<td>SPSS 25.0</td>
			<td>IBM</td>
			<td>Version 25.0</td>
			<td>https://www.ibm.com/support/pages/downloading-ibm-spss-statistics-25</td>
		</tr>
	</tbody>
</table>

application of a dual upper limb task-oriented robotic system for the functional recovery of the upper limb in stroke patients

Highly repetitive and task-oriented training has been shown to promote the recovery of limb function in stroke patients. Additionally, bilateral arm training can help stroke survivors regain their upper limb function and improve their daily activities. The dual upper limb task-oriented robotic system is designed to assist the healthy side of the stroke patient in driving the affected side to perform bilateral arm training through the use of a robotic device. It can also guide the patient in carrying out dual upper limb coordinated movements and engage them in a task-oriented virtual game using force feedback and human-computer interaction technology. This study aimed to assess the efficacy of the system in enhancing upper limb function and activities of daily living in stroke patients. The assessment methods used included motor evoked potential (MEP), functional test for the hemiplegic upper extremity-Hong Kong (FTHUE-HK), Fugl-Meyer Assessment Upper Extremity Scale (FMA-UE), and modified Barthel index (MBI). The results of the study indicate that the dual upper limb task-oriented robotic system can significantly improve the corticospinal pathway, upper limb function, and activities of daily living in stroke patients after 6 weeks of treatment. This system can serve as an effective adjunct to upper limb functional rehabilitation in stroke survivors, reducing the dependence on rehabilitation therapists. In conclusion, the dual upper limb task-oriented robotic system provides a new strategy for post-stroke limb functional rehabilitation and holds great potential for application, as it offers certain social and financial benefits.

Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients

Our research is focused on the rehabilitation of patients who have suffered a stroke or traumatic brain injury, and we're trying to investigate the impact of our robot-assisted to upper limb training strategy on the recovery of upper limb function in stroke patients. Our protocol integrates bilateral upper limb training, task-oriented activities, and robot-assisted training to enhance the rehabilitation of upper limb function in stroke patients. We will focus on the impact of neuromodulation technology, virtual reality technology, and artificial intelligence robotic assistants on post-stroke limb function rehabilitation.

A total of 60 stroke patients were divided into a control group (n = 30) and an experimental group (n = 30) for this study. Upon comparing age, gender, stroke type, disease duration, side of hemiplegia, and other general information between the two groups, no statistically significant differences were found (P &#62; 0.05), indicating their comparability (Table 1). Patients in the experimental group, who underwent training with a dual upper limb task-oriented robotic system, showed greater improvements in...

This experimental protocol outlines the use of a dual upper limb task-oriented robotic system for stroke patients with upper limb dysfunction. The findings indicate that this system can significantly improve stroke patients' upper limb function and daily living activities.

Highly repetitive and task-oriented training has been shown to promote the recovery of limb function in stroke patients. Additionally, bilateral arm ...

application-dual-upper-limb-task-oriented-robotic-system-for

Without Section

Research

JoVE Journal

Medicine

Dual Upper Limb Task-Oriented Robotic System Training Sessions for Stroke Patients with Upper Limb Dysfunction

To begin, start the robotic system equipment and turn on the system's computer. Open the ULCOT Rehab application and enter the main interface of the system. After entering the patient's details, click Log In and select the patient from the list.Assist the patient to sit in front of the robotic device, ensuring a safe and comfortable distance. Click Adjustment to set the appropriate parameters. In the platform height adjustment module, click on plus or minus to increase or decrease the height of the platform.Next, in the arm tilt angle adjustment module, click plus or minus to adjust the tilt angle of the robotic arm. In the arm angle adjustment module, click plus or minus to increase or decrease the angle between the two robot arms. Click Training to enter the training program setting interface.For patients unable to fully manipulate the mechanical handle on the hemiplegic side, click Assistance to enter the assisted training mode interface. Set the time to 30 minutes In the training time module, and select the level set for the patient in the assisted level module. Click Air Flying or Ping-Pong.Then, click Start To enter the game interface. In the Air Flying game, instruct the patient to use the affected upper limb through the healthy side with the assistance of a robotic device to control and guide the virtual airplane along the designated flight trajectory and capture gold coins. In the Ping-Pong game, with the assistance of the robot, instruct the patient to use the unaffected side to drive the affected-side upper limb to control the virtual table tennis racket.Move the racket to catch the flying ping-pong. For patients able to actively manipulate the mechanical handle on the hemiplegic side, click Resistance. Set the time to 30 minutes in the training time module.In the Healthy Level and Affected Level modules, select the resistance levels for the healthy side and the affected side respectively. In the healthy side resistance direction and affected side resistance direction modules, select the resistance direction indicated by the system for each side. In the Holding Time module, select the duration for holding the target.In the Bridge Road game, instruct the patient to complete the task of building a wooden bridge by resisting the resistance provided by the robotic arm on both the healthy and affected upper limbs. Control both ends of the wooden bridge displayed on the screen. Move two ladder platforms of different heights and hold them for a certain time to allow the virtual character to pass.In the Weightlifting game, instruct the patient to complete the task of pushing a barbell. Control the ends of a weightlifting barbell displayed on the screen. Adjust the barbell position to reach a target location and maintain the position for a specified time.In the Pop Matching game, instruct the patient to complete the task of deleting pictures. Have the patient control two virtual fingers located at the left and right ends of the screen. Then, select identical items from the left and right columns of pictures through the virtual fingers, and maintain this position for a designated duration.After six weeks of training, the experimental group demonstrated a higher detection ratio of motor evoked potentials compared to the control group. Following the training period, both groups of patients exhibited improvements in FTHUE-HK compared to pre-treatment levels. Improvements in FMA-UE and MBI scores were observed in control and experimental groups, indicating the recovery of upper limb function in stroke patients.

216 Views.  Graduate School of Zhejiang Chinese Medical University.  This experimental protocol outlines the use of a dual upper limb task-oriented robotic system for stroke patients with upper limb dysfunction. The findings indicate that this system can significantly improve stroke patients' upper limb function and daily living activities.

Dual Upper Limb Robotic Training in Stroke Rehabilitation

Summary