University of Malta
2 ARTICLES PUBLISHED IN JoVE
Bioengineering
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Shawn Baldacchino 1, Christian Saliba 2, Jeanesse Scerri 3, Christian Scerri 3, Godfrey Grech 1
1Department of Pathology, Faculty of Medicine & Surgery, University of Malta, 2Centre for Molecular Medicine and Biobanking, University of Malta, 3Department of Physiology & Biochemistry, Faculty of Medicine and Surgery, University of Malta
Nucleic acid degradation in archival tissue, tumor heterogeneity, and a lack of fresh frozen tissue specimens can negatively impact cancer diagnostic services in pathology laboratories worldwide. This manuscript describes the optimization of a panel of biomarkers using a multiplex magnetic bead assay to classify breast cancers.
Biology
Small Molecule Screening and Toxicity Testing in Early-stage Zebrafish Larvae
Margherita Muscat 1, Sherif Suleiman 2,3, Melissa M. Formosa 1,3
1Department of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, 2Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, 3Centre for Molecular Medicine and Biobanking, University of Malta
This protocol describes a drug screening procedure in zebrafish larvae 3-7 days post fertilization followed by morphological assessment.
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