Southwest Jiaotong University
2 ARTICLES PUBLISHED IN JoVE
Immunology and Infection
Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells
Shammy Raj 1, Lei Lu 2, Larry D. Unsworth 1
1Department of Chemical and Materials Engineering, Donadeo Innovation Centre for Engineering, University of Alberta, 2School of Life Science and Engineering, Southwest Jiaotong University
Techniques for generating a library of short peptides that can activate mast cells via the MRGPRX2 receptor are described. Associated techniques are easy, inexpensive, and can be extended to other cell receptors.
Chemistry
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Dan Fang 1, Rui Wang 1, Xinyi Yu 1, Yuan Tian 1
1Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University
This protocol describes the synthesis of cyclic cell-penetrating peptides with aromatic cross-links and the evaluation of their permeability across biological barriers.
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