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Southwest Jiaotong University

2 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells
Shammy Raj 1, Lei Lu 2, Larry D. Unsworth 1
1Department of Chemical and Materials Engineering, Donadeo Innovation Centre for Engineering, University of Alberta, 2School of Life Science and Engineering, Southwest Jiaotong University

Techniques for generating a library of short peptides that can activate mast cells via the MRGPRX2 receptor are described. Associated techniques are easy, inexpensive, and can be extended to other cell receptors.

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Chemistry

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Dan Fang 1, Rui Wang 1, Xinyi Yu 1, Yuan Tian 1
1Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University

This protocol describes the synthesis of cyclic cell-penetrating peptides with aromatic cross-links and the evaluation of their permeability across biological barriers.

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