Wroclaw Medical University
2 ARTICLES PUBLISHED IN JoVE
Immunology and Infection
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Magdalena Zemelka-Wiacek 1, Monika Majewska-Szczepanik 2, Pawel Gajdanowicz 1, Marian Szczepanik 3
1Department of Clinical Immunology, Wroclaw Medical University, 2Department of Medical Physiology, Chair of Biomedical Sciences, Institute of Physiotherapy, Faculty of Health Sciences, Jagiellonian University Medical College, 3Chair of Biomedical Sciences, Faculty of Health Sciences, Jagiellonian University Medical College
Contact hypersensitivity (CHS) is a murine experimental model of allergic contact dermatitis (ACD). CHS is based on sensitization with reactive hapten by painting the shaved skin of the chest and abdomen, with a subsequent ear skin challenge with a diluted hapten, causing a swelling reaction that is assessed in various ways.
Immunology and Infection
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Magdalena Zemelka-Wiacek 1, Anna Kosowska 1,2, Marek Jutel 1,2
1Department of Clinical Immunology, Wroclaw Medical University, 2ALL-MED Medical Research Institute
A protocol for conducting a challenge in an allergen exposure chamber (AEC) facility is presented. AECs have proven to be safe and effective tools for the induction of allergic symptoms or as an endpoint in the efficacy testing of allergen immunotherapy due to their ability to maintain stable particle concentrations and environmental conditions.
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