Friedrich Schiller University
2 ARTICLES PUBLISHED IN JoVE
Chemistry
Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
Julia Greiser 1, Tobias Niksch 1, Wolfgang Weigand 2, Martin Freesmeyer 1
1Clinic of Nuclear Medicine, University Hospital Jena, 2Friedrich Schiller University
A procedure for the isolation of EOB-DTPA and subsequent complexation with natural Ga(III) and 68Ga is presented herein, as well as a thorough analysis of all compounds and investigations on labeling efficiency, in vitro stability and the n-octanol/water distribution coefficient of the radiolabeled complex.
Immunology and Infection
Immunocompetent Intestine-on-Chip Model for Analyzing Gut Mucosal Immune Responses
Adrian Feile *1,2,3, Valentin D. Wegner *1, Martin Raasch 4, Alexander S. Mosig 1,2,3,5
1Institute of Biochemistry II, Jena University Hospital, 2Cluster of Excellence Balance of the Microverse, Friedrich Schiller University, 3Jena School of Microbial Communication, Friedrich Schiller University, 4Dynamic42 GmbH, 5Jena Center for Sepsis Control and Care, Jena University Hospital
Our detailed protocol outlines the creation and use of the advanced intestine-on-chip model, which simulates human intestinal mucosa with 3D structures and various cell types, enabling in-depth analysis of immune responses and cellular functions in response to microbial colonization.
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