Germans Trias i Pujol University Hospital
2 ARTICLES PUBLISHED IN JoVE
JoVE Core
Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
Aida Llucià-Valldeperas 1,2, Ramon Bragós 3, Antoni Bayés-Genís 1,4,5,6
1Insuficiencia Cardiaca y Regeneración Cardiaca (ICREC) Research Program, Health Science Research Institute Germans Trias i Pujol, 2Amsterdam Universitair Medisch Centrum (UMC), Vrije Universiteit Amsterdam, Pulmonology and Physiology, Amsterdam Cardiovascular Sciences, 3Electronic and Biomedical Instrumentation Group, Departament d'Enginyeria Electrònica, Universitat Politècnica de Catalunya, 4Cardiology Service, Germans Trias i Pujol University Hospital, 5Department of Medicine, Universitat Autònoma de Barcelona, 6Centro de Investigación Biomédica en Red (CIBER) Cardiovascular, Instituto de Salud Carlos III
Here we present a protocol for training a cell population using electrical and mechanical stimuli emulating cardiac physiology. This electromechanical stimulation enhances the cardiomyogenic potential of the treated cells and is a promising strategy for further cell therapy, disease modeling, and drug screening.
Medicine
Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model
Daina Martínez-Falguera *1,2, Edgar Fadeuilhe *3, Albert Teis 3, Julia Aranyo 3, Raquel Adeliño 1,3, Felipe Bisbal 3,4, Oriol Rodriguez-Leor 3,4, Carolina Gálvez-Montón 1,3,4
1ICREC Research Program, Germans Trias i Pujol Health Research Institute (IGTP), 2Faculty of Medicine, University of Barcelona (UB), 3Heart Institute (iCOR), Germans Trias i Pujol University Hospital, 4CIBER Cardiovascular, Instituto de Salud Carlos III
Myocardial infarction (MI) animal models that emulate the natural process of the disease in humans are crucial to understanding pathophysiological mechanisms and testing the safety and efficacy of new emergent therapies. Here, we describe an MI swine model created by deploying a percutaneous embolization coil.
