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Germans Trias i Pujol University Hospital

2 ARTICLES PUBLISHED IN JoVE

JoVE Core

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Aida Llucià-Valldeperas^1,2, Ramon Bragós³, Antoni Bayés-Genís^1,4,5,6

¹Insuficiencia Cardiaca y Regeneración Cardiaca (ICREC) Research Program, Health Science Research Institute Germans Trias i Pujol, ²Amsterdam Universitair Medisch Centrum (UMC), Vrije Universiteit Amsterdam, Pulmonology and Physiology, Amsterdam Cardiovascular Sciences, ³Electronic and Biomedical Instrumentation Group, Departament d'Enginyeria Electrònica, Universitat Politècnica de Catalunya, ⁴Cardiology Service, Germans Trias i Pujol University Hospital, ⁵Department of Medicine, Universitat Autònoma de Barcelona, ⁶Centro de Investigación Biomédica en Red (CIBER) Cardiovascular, Instituto de Salud Carlos III

Here we present a protocol for training a cell population using electrical and mechanical stimuli emulating cardiac physiology. This electromechanical stimulation enhances the cardiomyogenic potential of the treated cells and is a promising strategy for further cell therapy, disease modeling, and drug screening.

Medicine

Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model

Daina Martínez-Falguera^*1,2, Edgar Fadeuilhe^*3, Albert Teis³, Julia Aranyo³, Raquel Adeliño^1,3, Felipe Bisbal^3,4, Oriol Rodriguez-Leor^3,4, Carolina Gálvez-Montón^1,3,4

¹ICREC Research Program, Germans Trias i Pujol Health Research Institute (IGTP), ²Faculty of Medicine, University of Barcelona (UB), ³Heart Institute (iCOR), Germans Trias i Pujol University Hospital, ⁴CIBER Cardiovascular, Instituto de Salud Carlos III

Myocardial infarction (MI) animal models that emulate the natural process of the disease in humans are crucial to understanding pathophysiological mechanisms and testing the safety and efficacy of new emergent therapies. Here, we describe an MI swine model created by deploying a percutaneous embolization coil.