VA Health Care Center

1 ARTICLES PUBLISHED IN JoVE

Medicine

Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain

Hollis E. Krug^1,2, Christopher Dorman², Nicole Blanshan², Sandra Frizelle², Maren Mahowald^1,2

¹Department of Medicine, University of Minnesota, ²Research Department, VA Health Care Center

We have developed an evoked measure of arthritis pain and coupled it with a standardized method for measuring spontaneous pain in different murine models of chemically induced arthritis. These measures are sensitive and reproducible for different types of joint pain.