The University of Oklahoma
2 ARTICLES PUBLISHED IN JoVE
Bioengineering
Biaxial Mechanical Characterizations of Atrioventricular Heart Valves
Colton Ross *1, Devin Laurence *1, Yi Wu 1, Chung-Hao Lee 1,2
1Biomechanics and Biomaterials Design Laboratory (BBDL), School of Aerospace and Mechanical Engineering, The University of Oklahoma, 2Institute for Biomedical Engineering, Science and Technology (IBEST), The University of Oklahoma
This protocol involves characterizations of atrioventricular valve leaflets with force-controlled, displacement-controlled, and stress-relaxation biaxial mechanical testing procedures. Results acquired with this protocol can be used for constitutive model development to simulate the mechanical behavior of functioning valves under a finite element simulation framework.
Bioengineering
Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification
Katherine M. Casey 1, Devin W. Laurence 1, Mulan Tang 1, Chung-Hao Lee 1,2
1Biomechanics and Biomaterials Design Laboratory (BBDL), School of Aerospace and Mechanical Engineering, The University of Oklahoma, 2Institute for Biomedical Engineering, Science and Technology (IBEST), The University of Oklahoma
This protocol describes the biaxial mechanical characterization, polarized spatial frequency domain imaging-based collagen quantification, and microdissection of tricuspid valve leaflets. The provided method elucidates how the leaflet layers contribute to the holistic leaflet behaviors.
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